Comparing embolic particles for prostatic artery embolization to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia.
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| Title: | Comparing embolic particles for prostatic artery embolization to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia. |
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| Authors: | Bilhim, Tiago1,2 (AUTHOR) tiagobilhim@hotmail.com, Vasco Costa, Nuno1,2 (AUTHOR), Torres, Daniel1,2 (AUTHOR), Akış, Serhat3 (AUTHOR), Alves, Marta4,5 (AUTHOR), Papoila, Ana Luisa4,5 (AUTHOR) |
| Source: | European Radiology. Feb2025, Vol. 35 Issue 2, p1057-1066. 10p. |
| Subjects: | Benign prostatic hyperplasia, Polyvinyl alcohol, Urinary organs, Prostate-specific antigen, Standard deviations |
| Abstract: | Purpose: Compare the safety and efficacy of polyvinyl alcohol particles (PVA) versus trisacryl gelatin microspheres (Embospheres) versus hydrogel microspheres coated with polyzene-F (Embozenes) for prostatic artery embolization (PAE) to treat patients with benign prostatic hyperplasia (BPH). Materials and methods: A single-center prospective cohort study from 2019 to 2023, including patients with international prostate symptom score (IPSS) ≥ 15 and/or quality of life score (QoL) ≥ 4. Allocation to embolic agents was performed chronologically: 100–300 µm PVA (n = 53), followed by 300–500 µm Embospheres (n = 50), and finally, 400 µm Embozenes (n = 50). All patients were evaluated at baseline and at 1 and 6 months after PAE with IPSS/QoL; peak urinary flow rate, post-void residual volume, and prostate volume with ultrasound and prostate-specific antigen. Adverse events and the need for prostatic re-interventions were assessed. Results: There were no significant baseline differences between the three groups except for patient age (62.5 years PVA; 66.1 years Embospheres and 66.6 years Embozenes; p = 0.019). There were no major adverse events and no differences between groups regarding minor adverse events. All outcome measures improved significantly from baseline, with no significant differences between groups. Mean ± standard deviation IPSS/QoL improvement at 6 months: −10.7 ± 7.9/−2.2 ± 1.7 PVA; −10.4 ± 7.3/−2.0 ± 1.5 Embospheres; −10.4 ± 7.0/−2.2 ± 1.6 Embozenes (p = 0.987). Re-intervention rates after 6 months: 9% (n = 5/53) PVA; 14% (n = 7/50) Embospheres; 8% (n = 4/50) Embozenes (p = 0.591). Conclusions: PAE with PVA particles, Embospheres, and Embozenes is equally safe and effective in treating BPH-related lower urinary tract symptoms. Clinical relevance statement: This is the first prospective study showing equivalence between the most frequently used embolic agents for prostatic artery embolization. Key Points: Different particles can be used interchangeably for prostatic artery embolization. The improvements in measured metrics were the same between groups, with no differences in adverse events. The need for prostatic medication and re-intervention rates were the same at 1 and 6 months after embolization. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 182564639 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparing embolic particles for prostatic artery embolization to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bilhim%2C+Tiago%22">Bilhim, Tiago</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> tiagobilhim@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Vasco+Costa%2C+Nuno%22">Vasco Costa, Nuno</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torres%2C+Daniel%22">Torres, Daniel</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akış%2C+Serhat%22">Akış, Serhat</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alves%2C+Marta%22">Alves, Marta</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papoila%2C+Ana+Luisa%22">Papoila, Ana Luisa</searchLink><relatesTo>4,5</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Feb2025, Vol. 35 Issue 2, p1057-1066. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Benign+prostatic+hyperplasia%22">Benign prostatic hyperplasia</searchLink><br /><searchLink fieldCode="DE" term="%22Polyvinyl+alcohol%22">Polyvinyl alcohol</searchLink><br /><searchLink fieldCode="DE" term="%22Urinary+organs%22">Urinary organs</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate-specific+antigen%22">Prostate-specific antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Standard+deviations%22">Standard deviations</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Compare the safety and efficacy of polyvinyl alcohol particles (PVA) versus trisacryl gelatin microspheres (Embospheres) versus hydrogel microspheres coated with polyzene-F (Embozenes) for prostatic artery embolization (PAE) to treat patients with benign prostatic hyperplasia (BPH). Materials and methods: A single-center prospective cohort study from 2019 to 2023, including patients with international prostate symptom score (IPSS) ≥ 15 and/or quality of life score (QoL) ≥ 4. Allocation to embolic agents was performed chronologically: 100–300 µm PVA (n = 53), followed by 300–500 µm Embospheres (n = 50), and finally, 400 µm Embozenes (n = 50). All patients were evaluated at baseline and at 1 and 6 months after PAE with IPSS/QoL; peak urinary flow rate, post-void residual volume, and prostate volume with ultrasound and prostate-specific antigen. Adverse events and the need for prostatic re-interventions were assessed. Results: There were no significant baseline differences between the three groups except for patient age (62.5 years PVA; 66.1 years Embospheres and 66.6 years Embozenes; p = 0.019). There were no major adverse events and no differences between groups regarding minor adverse events. All outcome measures improved significantly from baseline, with no significant differences between groups. Mean ± standard deviation IPSS/QoL improvement at 6 months: −10.7 ± 7.9/−2.2 ± 1.7 PVA; −10.4 ± 7.3/−2.0 ± 1.5 Embospheres; −10.4 ± 7.0/−2.2 ± 1.6 Embozenes (p = 0.987). Re-intervention rates after 6 months: 9% (n = 5/53) PVA; 14% (n = 7/50) Embospheres; 8% (n = 4/50) Embozenes (p = 0.591). Conclusions: PAE with PVA particles, Embospheres, and Embozenes is equally safe and effective in treating BPH-related lower urinary tract symptoms. Clinical relevance statement: This is the first prospective study showing equivalence between the most frequently used embolic agents for prostatic artery embolization. Key Points: Different particles can be used interchangeably for prostatic artery embolization. The improvements in measured metrics were the same between groups, with no differences in adverse events. The need for prostatic medication and re-intervention rates were the same at 1 and 6 months after embolization. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-024-10998-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1057 Subjects: – SubjectFull: Benign prostatic hyperplasia Type: general – SubjectFull: Polyvinyl alcohol Type: general – SubjectFull: Urinary organs Type: general – SubjectFull: Prostate-specific antigen Type: general – SubjectFull: Standard deviations Type: general Titles: – TitleFull: Comparing embolic particles for prostatic artery embolization to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bilhim, Tiago – PersonEntity: Name: NameFull: Vasco Costa, Nuno – PersonEntity: Name: NameFull: Torres, Daniel – PersonEntity: Name: NameFull: Akış, Serhat – PersonEntity: Name: NameFull: Alves, Marta – PersonEntity: Name: NameFull: Papoila, Ana Luisa IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 2 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
