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Amide proton transfer-weighted MRI for assessing rectal adenocarcinoma T-staging and perineural invasion: a prospective study.

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Title: Amide proton transfer-weighted MRI for assessing rectal adenocarcinoma T-staging and perineural invasion: a prospective study.
Authors: Zhang, Caixia1 (AUTHOR), Chen, Jianyou1 (AUTHOR), Liu, Yifan1 (AUTHOR), Yang, Yinrui1 (AUTHOR), Xu, Yongzhou2 (AUTHOR), You, Ruimin1 (AUTHOR), Li, Yanli1 (AUTHOR), Liu, Lizhu1 (AUTHOR), Yang, Ling1 (AUTHOR), Li, Huaxiu1 (AUTHOR), Wang, Guanshun1 (AUTHOR) wgsh602@163.com, Li, Wenliang3 (AUTHOR) liwenliang@kmmu.edu.cn, Li, Zhenhui1 (AUTHOR) lizhenhui621@qq.com
Source: European Radiology. Feb2025, Vol. 35 Issue 2, p968-978. 11p.
Subjects: Magnetic resonance imaging, Receiver operating characteristic curves, Rectum tumors, Medical sciences, Prognosis
Abstract: Objective: To investigate the value of the pre-operative amide proton transfer-weighted (APTw) MRI to assess the prognostic factors in rectal adenocarcinoma (RA). Methods: This prospective study ran from January 2022 to September 2023 and consecutively enrolled participants with RA who underwent pre-operative MRI and radical surgery. The APTw signal intensity (SI) values of RA with various tumor (T), node (N) stages, perineural invasion (PNI), and tumor grade were compared by Mann–Whitney U-test or t-test. The receiver operating characteristic curve was used to evaluate the diagnostic performance of the APTw SI values. Results: A total of 51 participants were enrolled (mean age, 58 years ± 10 [standard deviation], 26 men). There were 24 in the T1–T2 stage and 9 with positive PNI. The APTw SI max, 99th, and 95th values were significantly higher in T3–T4 stage tumor than in T1-T2; the median (interquartile range) (M (IQR)) was (4.0% (3.6–4.9%) vs 3.4% (2.9– 4.3%), p = 0.017), (3.7% (3.2–4.1%) vs 3.2% (2.8–3.8%), p = 0.013), and (3.3% (2.8–3.8%) vs 2.9% (2.3–3.5%), p = 0.033), respectively. These indicators also differed significantly between the PNI groups, with the M (IQR) (4.5% (3.6–5.7%) vs 3.7% (3.2–4.2%), p = 0.017), (4.1% (3.4–4.8%) vs 3.3% (3.0–3.9%), p = 0.022), and (3.7% (2.7–4.2%) vs 2.9% (2.6–3.5%), p = 0.045), respectively. Conclusion: Pre-operative APTw MRI has potential value in the assessment of T-staging and PNI determination in RA. Clinical relevance statement: Pre-operative amide proton transfer-weighted MRI provides a quantitative method for noninvasive assessment of T-staging and PNI in RA aiding in precision treatment planning. Key Points: The efficacy of APTw MRI in RA needs further investigation. T3–T4 stage and PNI positive APTw signal intensities were higher than T1–T2 and non-PNI, respectively. APTw MRI provides a quantitative method for assessment of T staging and PNI in RA. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Amide proton transfer-weighted MRI for assessing rectal adenocarcinoma T-staging and perineural invasion: a prospective study.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Caixia%22">Zhang, Caixia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Jianyou%22">Chen, Jianyou</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yifan%22">Liu, Yifan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Yinrui%22">Yang, Yinrui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Yongzhou%22">Xu, Yongzhou</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22You%2C+Ruimin%22">You, Ruimin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yanli%22">Li, Yanli</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Lizhu%22">Liu, Lizhu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Ling%22">Yang, Ling</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Huaxiu%22">Li, Huaxiu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Guanshun%22">Wang, Guanshun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wgsh602@163.com</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Wenliang%22">Li, Wenliang</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> liwenliang@kmmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Zhenhui%22">Li, Zhenhui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lizhenhui621@qq.com</i>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Feb2025, Vol. 35 Issue 2, p968-978. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Receiver+operating+characteristic+curves%22">Receiver operating characteristic curves</searchLink><br /><searchLink fieldCode="DE" term="%22Rectum+tumors%22">Rectum tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To investigate the value of the pre-operative amide proton transfer-weighted (APTw) MRI to assess the prognostic factors in rectal adenocarcinoma (RA). Methods: This prospective study ran from January 2022 to September 2023 and consecutively enrolled participants with RA who underwent pre-operative MRI and radical surgery. The APTw signal intensity (SI) values of RA with various tumor (T), node (N) stages, perineural invasion (PNI), and tumor grade were compared by Mann–Whitney U-test or t-test. The receiver operating characteristic curve was used to evaluate the diagnostic performance of the APTw SI values. Results: A total of 51 participants were enrolled (mean age, 58 years ± 10 [standard deviation], 26 men). There were 24 in the T1–T2 stage and 9 with positive PNI. The APTw SI max, 99th, and 95th values were significantly higher in T3–T4 stage tumor than in T1-T2; the median (interquartile range) (M (IQR)) was (4.0% (3.6–4.9%) vs 3.4% (2.9– 4.3%), p = 0.017), (3.7% (3.2–4.1%) vs 3.2% (2.8–3.8%), p = 0.013), and (3.3% (2.8–3.8%) vs 2.9% (2.3–3.5%), p = 0.033), respectively. These indicators also differed significantly between the PNI groups, with the M (IQR) (4.5% (3.6–5.7%) vs 3.7% (3.2–4.2%), p = 0.017), (4.1% (3.4–4.8%) vs 3.3% (3.0–3.9%), p = 0.022), and (3.7% (2.7–4.2%) vs 2.9% (2.6–3.5%), p = 0.045), respectively. Conclusion: Pre-operative APTw MRI has potential value in the assessment of T-staging and PNI determination in RA. Clinical relevance statement: Pre-operative amide proton transfer-weighted MRI provides a quantitative method for noninvasive assessment of T-staging and PNI in RA aiding in precision treatment planning. Key Points: The efficacy of APTw MRI in RA needs further investigation. T3–T4 stage and PNI positive APTw signal intensities were higher than T1–T2 and non-PNI, respectively. APTw MRI provides a quantitative method for assessment of T staging and PNI in RA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-024-11000-2
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        Text: English
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