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Residential greenness and pollen exposure across gestational trimesters in relation to preschool wheezing: Results for the PIPO birth cohort.

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Title: Residential greenness and pollen exposure across gestational trimesters in relation to preschool wheezing: Results for the PIPO birth cohort.
Authors: De Troeyer, Katrien1 (AUTHOR) Katrien.DeTroeyer@uantwerpen.be, Grosso, Alessandro1 (AUTHOR), Heyvaert, Seppe2 (AUTHOR), Somers, Ben2 (AUTHOR), Mendoza, Hilbert1 (AUTHOR), Bentouhami, Hayat1 (AUTHOR), Hagendorens, Margo3 (AUTHOR), De Soomer, Kevin4 (AUTHOR), Oostveen, Ellie4 (AUTHOR), Verstraeten, Willem W.5 (AUTHOR), Delcloo, Andy5,6 (AUTHOR), Aerts, Raf1,7,8 (AUTHOR), Casas, Lidia1,9,10 (AUTHOR)
Source: Environmental Research. Feb2025, Vol. 267, pN.PAG-N.PAG. 1p.
Subjects: Normalized difference vegetation index, Pollen, Normalized measures, Odds ratio, Cohort analysis, Wheeze
Abstract: Previous studies on prenatal green space exposure and early respiratory health show inconsistent results. This may reflect stage-specific in utero effects and pollen influence. We examine associations of surrounding greenness and pollen exposure during pregnancy (overall and by trimester) with preschool wheezing, and assess potential mediation by pollen. We used data from the PIPO birth cohort (n = 860). Wheezing was reported biannually between 18 and 48 months of age. Residential greenness was measured with Normalized Difference Vegetation Index (NDVI) in 100 and 250 m buffer. Cumulative grass and birch pollen was estimated using modelled airborne pollen counts and categorized per trimester into no, low and high. All exposures were assessed for the overall pregnancy and per trimester. We used Generalized Estimated Equations to obtain odds ratios (OR) and 95% confidence intervals (CI). To assess mediation by pollen we used a data duplication algorithm with a generalized estimation approach. Approximately 10% of participants wheezed. During pregnancy, greenness (OR = 1.07, CI: 1.05–1.08) and grass pollen exposure (OR = 1.09, CI: 1.03–1.15) increased the odds of wheezing, while birch pollen decreased it (OR = 0.86, CI:0.87–1.00). Per trimester, more greenness during the 2nd trimester increased the odds (OR = 1.21, CI: 1.16–1.26), whereas third-trimester greenness decreased it (OR = 0.87, CI: 0.84–0.91). Grass pollen exposure in the 1st and 3rd trimesters increased the odds of wheezing (OR = 1.23, CI: 1.12–1.34 and OR = 1.13, CI: 1.00–1.27, respectively), while birch pollen exposure in the 1st and 2nd trimesters decreased the odds (OR = 0.88, CI: 0.77–1.00 and OR = 0.83, CI: 0.73–0.95, respectively). No significant associations were found for greenness in the 1st trimester, grass pollen in the 2nd trimester, and birch pollen in the 1st and 3rd trimester. Mediation analysis showed large uncertainty. Surrounding greenness and pollen exposure during pregnancy may impact the likelihood of preschool wheezing differently depending on the timing of exposure and the pollen type. [Display omitted] • Prenatal greenness was associated with preschool wheezing. • Grass pollen exposure in early/late pregnancy was directly associated with wheezing. • Birch pollen exposure in early pregnancy was inversely associated with wheezing. • The direction of the greenness/pollen and wheezing association varied by trimester. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Residential greenness and pollen exposure across gestational trimesters in relation to preschool wheezing: Results for the PIPO birth cohort.
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  Data: <searchLink fieldCode="AR" term="%22De+Troeyer%2C+Katrien%22">De Troeyer, Katrien</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Katrien.DeTroeyer@uantwerpen.be</i><br /><searchLink fieldCode="AR" term="%22Grosso%2C+Alessandro%22">Grosso, Alessandro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heyvaert%2C+Seppe%22">Heyvaert, Seppe</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Somers%2C+Ben%22">Somers, Ben</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mendoza%2C+Hilbert%22">Mendoza, Hilbert</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bentouhami%2C+Hayat%22">Bentouhami, Hayat</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hagendorens%2C+Margo%22">Hagendorens, Margo</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Soomer%2C+Kevin%22">De Soomer, Kevin</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oostveen%2C+Ellie%22">Oostveen, Ellie</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verstraeten%2C+Willem+W%2E%22">Verstraeten, Willem W.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Delcloo%2C+Andy%22">Delcloo, Andy</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aerts%2C+Raf%22">Aerts, Raf</searchLink><relatesTo>1,7,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Casas%2C+Lidia%22">Casas, Lidia</searchLink><relatesTo>1,9,10</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Research%22">Environmental Research</searchLink>. Feb2025, Vol. 267, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Normalized+difference+vegetation+index%22">Normalized difference vegetation index</searchLink><br /><searchLink fieldCode="DE" term="%22Pollen%22">Pollen</searchLink><br /><searchLink fieldCode="DE" term="%22Normalized+measures%22">Normalized measures</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Wheeze%22">Wheeze</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Previous studies on prenatal green space exposure and early respiratory health show inconsistent results. This may reflect stage-specific in utero effects and pollen influence. We examine associations of surrounding greenness and pollen exposure during pregnancy (overall and by trimester) with preschool wheezing, and assess potential mediation by pollen. We used data from the PIPO birth cohort (n = 860). Wheezing was reported biannually between 18 and 48 months of age. Residential greenness was measured with Normalized Difference Vegetation Index (NDVI) in 100 and 250 m buffer. Cumulative grass and birch pollen was estimated using modelled airborne pollen counts and categorized per trimester into no, low and high. All exposures were assessed for the overall pregnancy and per trimester. We used Generalized Estimated Equations to obtain odds ratios (OR) and 95% confidence intervals (CI). To assess mediation by pollen we used a data duplication algorithm with a generalized estimation approach. Approximately 10% of participants wheezed. During pregnancy, greenness (OR = 1.07, CI: 1.05–1.08) and grass pollen exposure (OR = 1.09, CI: 1.03–1.15) increased the odds of wheezing, while birch pollen decreased it (OR = 0.86, CI:0.87–1.00). Per trimester, more greenness during the 2nd trimester increased the odds (OR = 1.21, CI: 1.16–1.26), whereas third-trimester greenness decreased it (OR = 0.87, CI: 0.84–0.91). Grass pollen exposure in the 1st and 3rd trimesters increased the odds of wheezing (OR = 1.23, CI: 1.12–1.34 and OR = 1.13, CI: 1.00–1.27, respectively), while birch pollen exposure in the 1st and 2nd trimesters decreased the odds (OR = 0.88, CI: 0.77–1.00 and OR = 0.83, CI: 0.73–0.95, respectively). No significant associations were found for greenness in the 1st trimester, grass pollen in the 2nd trimester, and birch pollen in the 1st and 3rd trimester. Mediation analysis showed large uncertainty. Surrounding greenness and pollen exposure during pregnancy may impact the likelihood of preschool wheezing differently depending on the timing of exposure and the pollen type. [Display omitted] • Prenatal greenness was associated with preschool wheezing. • Grass pollen exposure in early/late pregnancy was directly associated with wheezing. • Birch pollen exposure in early pregnancy was inversely associated with wheezing. • The direction of the greenness/pollen and wheezing association varied by trimester. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.envres.2024.120646
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      – Code: eng
        Text: English
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      – SubjectFull: Normalized difference vegetation index
        Type: general
      – SubjectFull: Pollen
        Type: general
      – SubjectFull: Normalized measures
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      – SubjectFull: Odds ratio
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      – SubjectFull: Cohort analysis
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      – SubjectFull: Wheeze
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      – TitleFull: Residential greenness and pollen exposure across gestational trimesters in relation to preschool wheezing: Results for the PIPO birth cohort.
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              Text: Feb2025
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