14-3-3 promotes sarcolemmal expression of cardiac CaV1.2 and nucleates isoproterenol-triggered channel superclustering. - Spooner, Heather C.; Costa, Alexandre D.; Westhoff, Maartje; Hernández-González, Adriana; Ibrahimkhail, Husna; Yarov-Yarovoy, Vladimir; Horne, Mary C.; Dickson, Eamonn J.; Dixon, Rose E. (Proceedings of the National Academy of Sciences of the United States of America, 2025)