Synergistic anion-π interactions in peptidomimetic polyethers.
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| Title: | Synergistic anion-π interactions in peptidomimetic polyethers. |
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| Authors: | Seunghyun Lee1, Aram Shin2, Jinwoo Park1, Sowon Yun2, Minseong Kim2 mskim94@yonsei.ac.kr, Dong Woog Lee1 dongwoog.lee@unist.ac.kr, Byeong-Su Kim2 bskim19@yonsei.ac.kr |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 2/11/2025, Vol. 122 Issue 6, p1-7. 26p. |
| Subjects: | Ring-opening polymerization, Polyethers, Addition polymerization, Phenyl group, Aspartic acid |
| Abstract: | Anion-π interactions are crucial in various biological processes, such as enzyme catalysis and ion transport. Despite their significance, the exploitation of anion-π interactions in synthetic polymer systems remains underexplored. This study investigates anion-π interactions using chemically well-defined peptidomimetics guided by the composition of mussel foot proteins. Specifically, polyether-based polymers were designed utilizing two functional epoxide monomers--catechol acetonide glycidyl ether and 4,4-dimethyl- 2- oxazoline glycidyl ether--to mimic the key amino acids 3,4-dihydroxyphenylalanine and aspartic acid, respectively. A surface forces apparatus was employed to study the anion-π interaction between the polymers, considering the effects of relative monomer composition and pH conditions. The maximum cohesion energy of 15.0 mJ/m2 was observed at an equimolar monomer composition at pH 7. Incorporating a phenyl group instead of the catechol group and introducing competing anions confirmed the dominant role of anion-π interactions. This study highlights the significance of anion-π interactions, posing a high potential in the design and synthesis of functional materials. [ABSTRACT FROM AUTHOR] |
| Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 183159086 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synergistic anion-π interactions in peptidomimetic polyethers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Seunghyun+Lee%22">Seunghyun Lee</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Aram+Shin%22">Aram Shin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jinwoo+Park%22">Jinwoo Park</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sowon+Yun%22">Sowon Yun</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Minseong+Kim%22">Minseong Kim</searchLink><relatesTo>2</relatesTo><i> mskim94@yonsei.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Dong+Woog+Lee%22">Dong Woog Lee</searchLink><relatesTo>1</relatesTo><i> dongwoog.lee@unist.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Byeong-Su+Kim%22">Byeong-Su Kim</searchLink><relatesTo>2</relatesTo><i> bskim19@yonsei.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 2/11/2025, Vol. 122 Issue 6, p1-7. 26p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ring-opening+polymerization%22">Ring-opening polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethers%22">Polyethers</searchLink><br /><searchLink fieldCode="DE" term="%22Addition+polymerization%22">Addition polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Phenyl+group%22">Phenyl group</searchLink><br /><searchLink fieldCode="DE" term="%22Aspartic+acid%22">Aspartic acid</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Anion-π interactions are crucial in various biological processes, such as enzyme catalysis and ion transport. Despite their significance, the exploitation of anion-π interactions in synthetic polymer systems remains underexplored. This study investigates anion-π interactions using chemically well-defined peptidomimetics guided by the composition of mussel foot proteins. Specifically, polyether-based polymers were designed utilizing two functional epoxide monomers--catechol acetonide glycidyl ether and 4,4-dimethyl- 2- oxazoline glycidyl ether--to mimic the key amino acids 3,4-dihydroxyphenylalanine and aspartic acid, respectively. A surface forces apparatus was employed to study the anion-π interaction between the polymers, considering the effects of relative monomer composition and pH conditions. The maximum cohesion energy of 15.0 mJ/m2 was observed at an equimolar monomer composition at pH 7. Incorporating a phenyl group instead of the catechol group and introducing competing anions confirmed the dominant role of anion-π interactions. This study highlights the significance of anion-π interactions, posing a high potential in the design and synthesis of functional materials. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2419404122 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 26 StartPage: 1 Subjects: – SubjectFull: Ring-opening polymerization Type: general – SubjectFull: Polyethers Type: general – SubjectFull: Addition polymerization Type: general – SubjectFull: Phenyl group Type: general – SubjectFull: Aspartic acid Type: general Titles: – TitleFull: Synergistic anion-π interactions in peptidomimetic polyethers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Seunghyun Lee – PersonEntity: Name: NameFull: Aram Shin – PersonEntity: Name: NameFull: Jinwoo Park – PersonEntity: Name: NameFull: Sowon Yun – PersonEntity: Name: NameFull: Minseong Kim – PersonEntity: Name: NameFull: Dong Woog Lee – PersonEntity: Name: NameFull: Byeong-Su Kim IsPartOfRelationships: – BibEntity: Dates: – D: 11 M: 02 Text: 2/11/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00278424 Numbering: – Type: volume Value: 122 – Type: issue Value: 6 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
| ResultId | 1 |
