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Megastigmane glycosides from Heterosmilax yunnanensis and their neuroprotective activity.

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Title: Megastigmane glycosides from Heterosmilax yunnanensis and their neuroprotective activity.
Authors: Du, Rong-Rong1 (AUTHOR), Qin, Wen-Jie2 (AUTHOR), Duan, Xiu-Mei2 (AUTHOR), Zhang, Xu1 (AUTHOR), Yang, Ya-Nan1 (AUTHOR), Jiang, Jian-Shuang1 (AUTHOR), Yuan, Xiang1 (AUTHOR) yuanxiang@imm.ac.cn, Zhang, Pei-Cheng1 (AUTHOR) pczhang@imm.ac.cn
Source: Phytochemistry. Jun2025, Vol. 234, pN.PAG-N.PAG. 1p.
Subjects: Computational chemistry, Double bonds, Glycosides, Edaravone, Neuroprotective agents
Abstract: Ten previously undescribed megastigmane glycosides (1 – 5 , 8 – 12) and four known compounds (6 – 7 , 13 – 14) were isolated from the roots of Heterosmilax yunnanensis Gagnep. Their planar structures were determined by NMR, HRESIMS, UV and IR spectroscopic data. The absolute configurations were established through Rh 2 (OCOCF 3) 4 -induced ECD, quantum computational chemistry, experimental ECD and 13C chemical shift. The neuroprotective activity of the compounds was assessed in H 2 O 2 -induced PC12 cell model. Compounds 3 and 6 – 10 exhibited good neuroprotective activity compared to the positive control edaravone. Ten undescribed megastigmane glycosides were isolated from the roots of Heterosmilax yunnanensis Gagnep., which are diverse due to migration or absence of double bonds in side chain. The neuroprotective activities of compounds 6 , 7 , 8 , and 9 were superior to the positive control drug edaravone. [Display omitted] • Ten undescribed megastigmane glycosides were isolated from H. yunnanensis. • These compounds are diverse due to migration or absence of double bonds. • Various methods were applied to confirm the absolute configuration. • Compounds 3 and 6 – 10 exhibit good neuroprotective activity. [ABSTRACT FROM AUTHOR]
Copyright of Phytochemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 183548276
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Megastigmane glycosides from Heterosmilax yunnanensis and their neuroprotective activity.
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  Data: <searchLink fieldCode="AR" term="%22Du%2C+Rong-Rong%22">Du, Rong-Rong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qin%2C+Wen-Jie%22">Qin, Wen-Jie</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duan%2C+Xiu-Mei%22">Duan, Xiu-Mei</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xu%22">Zhang, Xu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Ya-Nan%22">Yang, Ya-Nan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Jian-Shuang%22">Jiang, Jian-Shuang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Xiang%22">Yuan, Xiang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yuanxiang@imm.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Pei-Cheng%22">Zhang, Pei-Cheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pczhang@imm.ac.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Phytochemistry%22">Phytochemistry</searchLink>. Jun2025, Vol. 234, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Computational+chemistry%22">Computational chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Double+bonds%22">Double bonds</searchLink><br /><searchLink fieldCode="DE" term="%22Glycosides%22">Glycosides</searchLink><br /><searchLink fieldCode="DE" term="%22Edaravone%22">Edaravone</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroprotective+agents%22">Neuroprotective agents</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Ten previously undescribed megastigmane glycosides (1 – 5 , 8 – 12) and four known compounds (6 – 7 , 13 – 14) were isolated from the roots of Heterosmilax yunnanensis Gagnep. Their planar structures were determined by NMR, HRESIMS, UV and IR spectroscopic data. The absolute configurations were established through Rh 2 (OCOCF 3) 4 -induced ECD, quantum computational chemistry, experimental ECD and 13C chemical shift. The neuroprotective activity of the compounds was assessed in H 2 O 2 -induced PC12 cell model. Compounds 3 and 6 – 10 exhibited good neuroprotective activity compared to the positive control edaravone. Ten undescribed megastigmane glycosides were isolated from the roots of Heterosmilax yunnanensis Gagnep., which are diverse due to migration or absence of double bonds in side chain. The neuroprotective activities of compounds 6 , 7 , 8 , and 9 were superior to the positive control drug edaravone. [Display omitted] • Ten undescribed megastigmane glycosides were isolated from H. yunnanensis. • These compounds are diverse due to migration or absence of double bonds. • Various methods were applied to confirm the absolute configuration. • Compounds 3 and 6 – 10 exhibit good neuroprotective activity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Phytochemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.phytochem.2025.114432
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Computational chemistry
        Type: general
      – SubjectFull: Double bonds
        Type: general
      – SubjectFull: Glycosides
        Type: general
      – SubjectFull: Edaravone
        Type: general
      – SubjectFull: Neuroprotective agents
        Type: general
    Titles:
      – TitleFull: Megastigmane glycosides from Heterosmilax yunnanensis and their neuroprotective activity.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Du, Rong-Rong
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            NameFull: Qin, Wen-Jie
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            NameFull: Duan, Xiu-Mei
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            NameFull: Zhang, Xu
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            NameFull: Yang, Ya-Nan
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            NameFull: Jiang, Jian-Shuang
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            NameFull: Yuan, Xiang
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            NameFull: Zhang, Pei-Cheng
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            – D: 01
              M: 06
              Text: Jun2025
              Type: published
              Y: 2025
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            – Type: issn-print
              Value: 00319422
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              Value: 234
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            – TitleFull: Phytochemistry
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