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The Magnaporthe oryzae effector MoBys1 suppresses rice immunity by targeting OsCAD2 to manipulate host jasmonate and lignin metabolism.

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Title: The Magnaporthe oryzae effector MoBys1 suppresses rice immunity by targeting OsCAD2 to manipulate host jasmonate and lignin metabolism.
Authors: Liu, Chengyu1,2 (AUTHOR), Han, Li‐Bo1,2 (AUTHOR), Wen, Yanhong2 (AUTHOR), Lu, Chuner2 (AUTHOR), Deng, Boqian2 (AUTHOR), Liu, Zixuan2 (AUTHOR), Deng, Xianya2 (AUTHOR), Shen, Ningning1 (AUTHOR), Tang, Dingzhong1,2 (AUTHOR) dztang@fafu.edu.cn, Li, Yuan‐Bao1,2 (AUTHOR) yuanbaoli312@126.com
Source: New Phytologist. Apr2025, Vol. 246 Issue 1, p280-297. 18p.
Subjects: Transcription factors, Pyricularia oryzae, Alcohol dehydrogenase, Disease resistance of plants, Rice blast disease, Plant defenses
Abstract: Summary: Rice blast disease caused by Magnaporthe oryzae poses a severe threat to rice production. To counteract M. oryzae, plants synthesize jasmonate (JA) and lignin, two primary defense‐related metabolites, to initiate defense programs. However, the mechanism through which M. oryzae modulates JA‐ and lignin‐mediated plant immunity remains unclear.In this study, a novel M. oryzae effector, MoBys1, was identified as being involved in pathogenesis. Knockout of MoBys1 in M. oryzae significantly reduced its infection ability. Conversely, overexpression of MoBys1 in rice impaired the rice defense response. MoBys1 localizes to the plant cytoplasm and nucleus and interacts with rice cinnamyl alcohol dehydrogenase 2 (OsCAD2), an enzyme that catalyzes lignin biosynthesis. While OsCAD2 mutants exhibited weakened defenses, overexpression lines demonstrated enhanced resistance, highlighting the critical role of OsCAD2 in blast resistance.Furthermore, OsCAD2 functions as a transcription factor regulating a wide range of biological processes, including JA and lignin signaling pathways. The interaction between MoBys1 and OsCAD2 promotes OsCAD2 degradation, leading to reduced lignin and JA accumulation.These findings uncover a novel counter‐defense mechanism by which M. oryzae employs the effector MoBys1 to degrade OsCAD2 and suppress host defense‐related metabolite accumulation during infection. [ABSTRACT FROM AUTHOR]
Copyright of New Phytologist is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Header DbId: egs
DbLabel: Engineering Source
An: 183600974
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: The Magnaporthe oryzae effector MoBys1 suppresses rice immunity by targeting OsCAD2 to manipulate host jasmonate and lignin metabolism.
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  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Chengyu%22">Liu, Chengyu</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Li‐Bo%22">Han, Li‐Bo</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wen%2C+Yanhong%22">Wen, Yanhong</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Chuner%22">Lu, Chuner</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Boqian%22">Deng, Boqian</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Zixuan%22">Liu, Zixuan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Xianya%22">Deng, Xianya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Ningning%22">Shen, Ningning</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Dingzhong%22">Tang, Dingzhong</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> dztang@fafu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Yuan‐Bao%22">Li, Yuan‐Bao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> yuanbaoli312@126.com</i>
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  Data: <searchLink fieldCode="JN" term="%22New+Phytologist%22">New Phytologist</searchLink>. Apr2025, Vol. 246 Issue 1, p280-297. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Transcription+factors%22">Transcription factors</searchLink><br /><searchLink fieldCode="DE" term="%22Pyricularia+oryzae%22">Pyricularia oryzae</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+dehydrogenase%22">Alcohol dehydrogenase</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+resistance+of+plants%22">Disease resistance of plants</searchLink><br /><searchLink fieldCode="DE" term="%22Rice+blast+disease%22">Rice blast disease</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+defenses%22">Plant defenses</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Summary: Rice blast disease caused by Magnaporthe oryzae poses a severe threat to rice production. To counteract M. oryzae, plants synthesize jasmonate (JA) and lignin, two primary defense‐related metabolites, to initiate defense programs. However, the mechanism through which M. oryzae modulates JA‐ and lignin‐mediated plant immunity remains unclear.In this study, a novel M. oryzae effector, MoBys1, was identified as being involved in pathogenesis. Knockout of MoBys1 in M. oryzae significantly reduced its infection ability. Conversely, overexpression of MoBys1 in rice impaired the rice defense response. MoBys1 localizes to the plant cytoplasm and nucleus and interacts with rice cinnamyl alcohol dehydrogenase 2 (OsCAD2), an enzyme that catalyzes lignin biosynthesis. While OsCAD2 mutants exhibited weakened defenses, overexpression lines demonstrated enhanced resistance, highlighting the critical role of OsCAD2 in blast resistance.Furthermore, OsCAD2 functions as a transcription factor regulating a wide range of biological processes, including JA and lignin signaling pathways. The interaction between MoBys1 and OsCAD2 promotes OsCAD2 degradation, leading to reduced lignin and JA accumulation.These findings uncover a novel counter‐defense mechanism by which M. oryzae employs the effector MoBys1 to degrade OsCAD2 and suppress host defense‐related metabolite accumulation during infection. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of New Phytologist is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/nph.20440
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 280
    Subjects:
      – SubjectFull: Transcription factors
        Type: general
      – SubjectFull: Pyricularia oryzae
        Type: general
      – SubjectFull: Alcohol dehydrogenase
        Type: general
      – SubjectFull: Disease resistance of plants
        Type: general
      – SubjectFull: Rice blast disease
        Type: general
      – SubjectFull: Plant defenses
        Type: general
    Titles:
      – TitleFull: The Magnaporthe oryzae effector MoBys1 suppresses rice immunity by targeting OsCAD2 to manipulate host jasmonate and lignin metabolism.
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              M: 04
              Text: Apr2025
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              Y: 2025
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