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A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking.

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Title: A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking.
Authors: Pu, Yinying1 (AUTHOR), Duan, Yangying1 (AUTHOR), Li, Wenhao1 (AUTHOR), Lin, Han2 (AUTHOR), Li, Qiyue1 (AUTHOR), Yin, Binxu1 (AUTHOR), Zhang, Kun1 (AUTHOR) zhang1986kun@126.com, Zhou, Bangguo1,3 (AUTHOR) 913565417@qq.com, Wu, Wencheng1 (AUTHOR) wuwencheng@uestc.edu.cn
Source: Journal of Controlled Release. Apr2025, Vol. 380, p404-416. 13p.
Subjects: Acute kidney failure, Reactive oxygen species, Oxidation-reduction reaction, Oxidative stress, Cerium
Abstract: Reactive oxygen species (ROS) play a major role in driving acute kidney injury (AKI) by causing oxidative stress and triggering inflammatory responses. However, treatment of AKI with traditional nanomedicines is still challenging because of low ROS scavenging efficacy and poor inflammatory chemotactic. Herein, we have constructed a novel cerium single-atom catalyst (A-CeSACs) for AKI catalytic therapy which targets inflammation and mimics several enzymatic redox activities. After injection of A-CeSACs into AKI mice via tail vein, targeting damaged kidney sites is realized by hitchhiking neutrophils that naturally target sites of inflammation via chemotaxis. After entering the AKI inflammatory environment, A-CeSACs rapidly scavenge multiple ROS via the Ce3+/Ce4+ redox reaction, thus reducing the release of inflammatory factors. The designed A-CeSACs displayed remarkably catalytic therapy efficacy in glycerol-induced AKI mice models. Overall, the present study describes a novel therapeutic strategy for targeted AKI catalytic therapy that is also potentially applicable to other inflammation-related diseases. [Display omitted] • Novel-synthesied cerium single-atom catalysts with multi-enzyme activities for effectively ROS scavenging. • A novel strategy for AKI targeted delivery of antioxidants by neutrophils hitchhiking. • Highly efficient AKI-targeted antioxidant therapy. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 183703464
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Pu%2C+Yinying%22">Pu, Yinying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duan%2C+Yangying%22">Duan, Yangying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Wenhao%22">Li, Wenhao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Han%22">Lin, Han</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Qiyue%22">Li, Qiyue</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yin%2C+Binxu%22">Yin, Binxu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Kun%22">Zhang, Kun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zhang1986kun@126.com</i><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Bangguo%22">Zhou, Bangguo</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> 913565417@qq.com</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Wencheng%22">Wu, Wencheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wuwencheng@uestc.edu.cn</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Apr2025, Vol. 380, p404-416. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Acute+kidney+failure%22">Acute kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidation-reduction+reaction%22">Oxidation-reduction reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Cerium%22">Cerium</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Reactive oxygen species (ROS) play a major role in driving acute kidney injury (AKI) by causing oxidative stress and triggering inflammatory responses. However, treatment of AKI with traditional nanomedicines is still challenging because of low ROS scavenging efficacy and poor inflammatory chemotactic. Herein, we have constructed a novel cerium single-atom catalyst (A-CeSACs) for AKI catalytic therapy which targets inflammation and mimics several enzymatic redox activities. After injection of A-CeSACs into AKI mice via tail vein, targeting damaged kidney sites is realized by hitchhiking neutrophils that naturally target sites of inflammation via chemotaxis. After entering the AKI inflammatory environment, A-CeSACs rapidly scavenge multiple ROS via the Ce3+/Ce4+ redox reaction, thus reducing the release of inflammatory factors. The designed A-CeSACs displayed remarkably catalytic therapy efficacy in glycerol-induced AKI mice models. Overall, the present study describes a novel therapeutic strategy for targeted AKI catalytic therapy that is also potentially applicable to other inflammation-related diseases. [Display omitted] • Novel-synthesied cerium single-atom catalysts with multi-enzyme activities for effectively ROS scavenging. • A novel strategy for AKI targeted delivery of antioxidants by neutrophils hitchhiking. • Highly efficient AKI-targeted antioxidant therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jconrel.2025.02.011
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 404
    Subjects:
      – SubjectFull: Acute kidney failure
        Type: general
      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Oxidation-reduction reaction
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Cerium
        Type: general
    Titles:
      – TitleFull: A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking.
        Type: main
  BibRelationships:
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      – PersonEntity:
          Name:
            NameFull: Pu, Yinying
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          Name:
            NameFull: Duan, Yangying
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            NameFull: Li, Wenhao
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            NameFull: Lin, Han
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            NameFull: Li, Qiyue
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            NameFull: Yin, Binxu
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            NameFull: Zhang, Kun
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            NameFull: Zhou, Bangguo
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            NameFull: Wu, Wencheng
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            – D: 10
              M: 04
              Text: Apr2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 01683659
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            – Type: volume
              Value: 380
          Titles:
            – TitleFull: Journal of Controlled Release
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