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Amelioratory Role of Lactobacillus paracasei N1115 on Blood Glucose, Inflammation, Cognitive Function, and Gut Microbiota Composition in Type 2 Diabetes Mellitus Rats.

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Title: Amelioratory Role of Lactobacillus paracasei N1115 on Blood Glucose, Inflammation, Cognitive Function, and Gut Microbiota Composition in Type 2 Diabetes Mellitus Rats.
Authors: Li, Qing1 (AUTHOR), Feng, Feng2 (AUTHOR), Bian, Yanqing1 (AUTHOR), Zhao, Hanyi1 (AUTHOR), Cao, Sijia1 (AUTHOR), Sun, Dongzhe1 (AUTHOR), Jiao, Tianyue1 (AUTHOR), Zhao, Baohua1 (AUTHOR) zhaobaohua@mail.hebtu.edu.cn, Peng, Liping1 (AUTHOR) pengliping@mail.hebtu.edu.cn, Basharat, Zarrin (AUTHOR)
Source: Journal of Food Biochemistry. 2/28/2025, Vol. 2025, p1-13. 13p.
Subjects: Type 2 diabetes, Cognitive ability, Weight loss, Gut microbiota, Blood sugar
Abstract: This study aims to investigate the effect of probiotic Lactobacillus paracasei N1115 on Type 2 diabetes mellitus (T2DM) rats. SD rats were randomly divided into 5 groups, including control group (ND), diabetes mellitus (DM) group, and high (109 CFU/mL), medium (108 CFU/mL), or low (107 CFU/mL) doses of probiotics intervention groups. The ND rats were fed a normal diet, and the others were fed a high‐fat diet and injected with streptozotocin (STZ) to build a T2DM model. In the three probiotic intervention groups, rats were given high, medium, or low doses of L. paracasei N1115 by gavage for 12 weeks. Results indicated that probiotics could prevent weight loss and decrease the blood glucose levels of T2DM rats, in a dose‐dependent manner. A high dose of L. paracasei N1115 also led to a significant decline in the inflammatory response by regulating the TLR4/NF‐κB inflammatory pathway and reducing proinflammatory cytokines, such as tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), and lipopolysaccharide (LPS) (p < 0.05). Besides, the memory factor cAMP and the cognitive regulatory pathway BDNF/TrkB were increased by high dose of L. paracasei N1115 treatment (p < 0.05), revealing an enhanced cognitive memory competence. In addition, analysis of the gut microbiome showed that a high dose of L.paracasei N1115 decreased Firmicutes/Bacteroidota ratio and increased the relative abundance of beneficial bacteria, such as unclassified_Lachnospiraceae, Ligilactobacillus, and Lachnospiraceae_NK4A136_group. The microbial gene contents associated with metabolic pathways, nicotinate and nicotinamide metabolism, glycine, serine, and threonine metabolism and the citrate cycle were upregulated under L. paracasei N1115 treatment. In summary, this study elucidated the regulatory effects of L. paracasei N1115 on T2DM in rats and revealed a promising dietary supplement for the treatment of T2DM. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Amelioratory Role of Lactobacillus paracasei N1115 on Blood Glucose, Inflammation, Cognitive Function, and Gut Microbiota Composition in Type 2 Diabetes Mellitus Rats.
– Name: Author
  Label: Authors
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Qing%22&quot;&gt;Li, Qing&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Feng%2C+Feng%22&quot;&gt;Feng, Feng&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bian%2C+Yanqing%22&quot;&gt;Bian, Yanqing&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhao%2C+Hanyi%22&quot;&gt;Zhao, Hanyi&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cao%2C+Sijia%22&quot;&gt;Cao, Sijia&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sun%2C+Dongzhe%22&quot;&gt;Sun, Dongzhe&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiao%2C+Tianyue%22&quot;&gt;Jiao, Tianyue&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhao%2C+Baohua%22&quot;&gt;Zhao, Baohua&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; zhaobaohua@mail.hebtu.edu.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Peng%2C+Liping%22&quot;&gt;Peng, Liping&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; pengliping@mail.hebtu.edu.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Basharat%2C+Zarrin%22&quot;&gt;Basharat, Zarrin&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Food+Biochemistry%22&quot;&gt;Journal of Food Biochemistry&lt;/searchLink&gt;. 2/28/2025, Vol. 2025, p1-13. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Type+2+diabetes%22&quot;&gt;Type 2 diabetes&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognitive+ability%22&quot;&gt;Cognitive ability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Weight+loss%22&quot;&gt;Weight loss&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gut+microbiota%22&quot;&gt;Gut microbiota&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+sugar%22&quot;&gt;Blood sugar&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study aims to investigate the effect of probiotic Lactobacillus paracasei N1115 on Type 2 diabetes mellitus (T2DM) rats. SD rats were randomly divided into 5 groups, including control group (ND), diabetes mellitus (DM) group, and high (109 CFU/mL), medium (108 CFU/mL), or low (107 CFU/mL) doses of probiotics intervention groups. The ND rats were fed a normal diet, and the others were fed a high‐fat diet and injected with streptozotocin (STZ) to build a T2DM model. In the three probiotic intervention groups, rats were given high, medium, or low doses of L. paracasei N1115 by gavage for 12 weeks. Results indicated that probiotics could prevent weight loss and decrease the blood glucose levels of T2DM rats, in a dose‐dependent manner. A high dose of L. paracasei N1115 also led to a significant decline in the inflammatory response by regulating the TLR4/NF‐κB inflammatory pathway and reducing proinflammatory cytokines, such as tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), and lipopolysaccharide (LPS) (p &lt; 0.05). Besides, the memory factor cAMP and the cognitive regulatory pathway BDNF/TrkB were increased by high dose of L. paracasei N1115 treatment (p &lt; 0.05), revealing an enhanced cognitive memory competence. In addition, analysis of the gut microbiome showed that a high dose of L.paracasei N1115 decreased Firmicutes/Bacteroidota ratio and increased the relative abundance of beneficial bacteria, such as unclassified_Lachnospiraceae, Ligilactobacillus, and Lachnospiraceae_NK4A136_group. The microbial gene contents associated with metabolic pathways, nicotinate and nicotinamide metabolism, glycine, serine, and threonine metabolism and the citrate cycle were upregulated under L. paracasei N1115 treatment. In summary, this study elucidated the regulatory effects of L. paracasei N1115 on T2DM in rats and revealed a promising dietary supplement for the treatment of T2DM. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/jfbc/6891209
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 1
    Subjects:
      – SubjectFull: Type 2 diabetes
        Type: general
      – SubjectFull: Cognitive ability
        Type: general
      – SubjectFull: Weight loss
        Type: general
      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Blood sugar
        Type: general
    Titles:
      – TitleFull: Amelioratory Role of Lactobacillus paracasei N1115 on Blood Glucose, Inflammation, Cognitive Function, and Gut Microbiota Composition in Type 2 Diabetes Mellitus Rats.
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            NameFull: Li, Qing
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              M: 02
              Text: 2/28/2025
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              Y: 2025
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              Value: 2025
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