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Evaluation of an integrated variable flip angle protocol to estimate coil B1 for hyperpolarized MRI.

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Title: Evaluation of an integrated variable flip angle protocol to estimate coil B1 for hyperpolarized MRI.
Authors: Yeung, Kylie1,2,3 (AUTHOR), Ng, Kher Lik3,4 (AUTHOR), McGing, Jordan J.1 (AUTHOR), Axford, Aaron1 (AUTHOR), Birkhoelzer, Sarah1 (AUTHOR), Shinozaki, Ayaka1,5 (AUTHOR), Ricchi, Mattia1,6,7 (AUTHOR), Sgambelluri, Noemi1,8 (AUTHOR), Zaccagna, Fulvio1,9 (AUTHOR), Mills, Rebecca1 (AUTHOR), Lewis, Andrew J. M.1 (AUTHOR), Rayner, Jennifer J.1 (AUTHOR), Ravetz, Zack1,10 (AUTHOR), Berner, Lise3 (AUTHOR), Jacob, Kenneth3 (AUTHOR), McIntyre, Anthony3 (AUTHOR), Durrant, Marianne3 (AUTHOR), Rider, Oliver J.1 (AUTHOR), Schulte, Rolf F.11 (AUTHOR), Gleeson, Fergus V.2,3 (AUTHOR)
Source: Magnetic Resonance in Medicine. Apr2025, Vol. 93 Issue 4, p1615-1628. 14p.
Subjects: Diagnostic imaging, Brain imaging, Lungs, Magnetic resonance imaging
Abstract: Purpose: The purpose of this work is to validate a simple and versatile integrated variable flip angle (VFA) method for mapping B1 in hyperpolarized MRI, which can be used to correct signal variations due to coil inhomogeneity. Theory and Methods: Simulations were run to assess performance of the VFA B1 mapping method compared to the currently used constant flip angle (CFA) approach. Simulation results were used to inform the design of VFA sequences, validated in four volunteers for hyperpolarized xenon‐129 imaging of the lungs and another four volunteers for hyperpolarized carbon‐13 imaging of the human brain. B1 maps obtained were used to correct transmit and receive inhomogeneity in the images. Results: Simulations showed improved performance of the VFA approach over the CFA approach with reduced sensitivity to T1. For xenon‐129, the B1 maps accurately reflected the variation of signal depolarization, but in some cases could not be used to correct for coil receive inhomogeneity due to a lack of transmit‐receive reciprocity resulting from suboptimal coil positioning. For carbon‐13, the B1 maps showed good agreement with a separately acquired B1 map of a phantom and were effectively used to correct coil‐induced signal inhomogeneity. Conclusion: A simple, versatile, and effective VFA B1 mapping method was implemented and evaluated. Inclusion of the B1 mapping method in hyperpolarized imaging studies can enable more robust signal quantification. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evaluation of an integrated variable flip angle protocol to estimate coil B<subscript>1</subscript> for hyperpolarized MRI.
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  Data: <searchLink fieldCode="AR" term="%22Yeung%2C+Kylie%22">Yeung, Kylie</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ng%2C+Kher+Lik%22">Ng, Kher Lik</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McGing%2C+Jordan+J%2E%22">McGing, Jordan J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Axford%2C+Aaron%22">Axford, Aaron</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birkhoelzer%2C+Sarah%22">Birkhoelzer, Sarah</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shinozaki%2C+Ayaka%22">Shinozaki, Ayaka</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ricchi%2C+Mattia%22">Ricchi, Mattia</searchLink><relatesTo>1,6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sgambelluri%2C+Noemi%22">Sgambelluri, Noemi</searchLink><relatesTo>1,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zaccagna%2C+Fulvio%22">Zaccagna, Fulvio</searchLink><relatesTo>1,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mills%2C+Rebecca%22">Mills, Rebecca</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewis%2C+Andrew+J%2E+M%2E%22">Lewis, Andrew J. M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rayner%2C+Jennifer+J%2E%22">Rayner, Jennifer J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ravetz%2C+Zack%22">Ravetz, Zack</searchLink><relatesTo>1,10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berner%2C+Lise%22">Berner, Lise</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jacob%2C+Kenneth%22">Jacob, Kenneth</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McIntyre%2C+Anthony%22">McIntyre, Anthony</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Durrant%2C+Marianne%22">Durrant, Marianne</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rider%2C+Oliver+J%2E%22">Rider, Oliver J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulte%2C+Rolf+F%2E%22">Schulte, Rolf F.</searchLink><relatesTo>11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gleeson%2C+Fergus+V%2E%22">Gleeson, Fergus V.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Apr2025, Vol. 93 Issue 4, p1615-1628. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: The purpose of this work is to validate a simple and versatile integrated variable flip angle (VFA) method for mapping B1 in hyperpolarized MRI, which can be used to correct signal variations due to coil inhomogeneity. Theory and Methods: Simulations were run to assess performance of the VFA B1 mapping method compared to the currently used constant flip angle (CFA) approach. Simulation results were used to inform the design of VFA sequences, validated in four volunteers for hyperpolarized xenon‐129 imaging of the lungs and another four volunteers for hyperpolarized carbon‐13 imaging of the human brain. B1 maps obtained were used to correct transmit and receive inhomogeneity in the images. Results: Simulations showed improved performance of the VFA approach over the CFA approach with reduced sensitivity to T1. For xenon‐129, the B1 maps accurately reflected the variation of signal depolarization, but in some cases could not be used to correct for coil receive inhomogeneity due to a lack of transmit‐receive reciprocity resulting from suboptimal coil positioning. For carbon‐13, the B1 maps showed good agreement with a separately acquired B1 map of a phantom and were effectively used to correct coil‐induced signal inhomogeneity. Conclusion: A simple, versatile, and effective VFA B1 mapping method was implemented and evaluated. Inclusion of the B1 mapping method in hyperpolarized imaging studies can enable more robust signal quantification. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30378
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              Text: Apr2025
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