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T1 and T2 measurements of the neonatal brain at 7 T.

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Title: T1 and T2 measurements of the neonatal brain at 7 T.
Authors: Mahmoud, Aiman1 (AUTHOR), Tomi‐Tricot, Raphael2,3 (AUTHOR), Leitão, David1 (AUTHOR), Bridgen, Philippa2,4 (AUTHOR), Price, Anthony N.4,5 (AUTHOR), Uus, Alena5 (AUTHOR), Boutillon, Arnaud1,5 (AUTHOR), Lawrence, Andrew J.6 (AUTHOR), Cromb, Daniel5 (AUTHOR), Cawley, Paul4,5 (AUTHOR), Deprez, Maria1,5 (AUTHOR), De Vita, Enrico2 (AUTHOR), Giles, Sharon L.2,4 (AUTHOR), Rutherford, Mary A.5 (AUTHOR), Edwards, A. David4,5,7 (AUTHOR), Hajnal, Joseph V.1,2,5 (AUTHOR), Arichi, Tomoki4,5,7 (AUTHOR), Malik, Shaihan J.1,2,5 (AUTHOR) shaihan.malik@kcl.ac.uk
Source: Magnetic Resonance in Medicine. May2025, Vol. 93 Issue 5, p2153-2162. 10p.
Subjects: Magnetic resonance imaging, Gray matter (Nerve tissue), White matter (Nerve tissue), Basal ganglia, Image segmentation
Abstract: Purpose: To determine the expected range of NMR relaxation times (T1 and T2) in the neonatal brain at 7 T. Methods: Data were acquired in a total of 40 examinations on infants in natural sleep. The cohort included 34 unique subjects with postmenstrual age range between 33 and 52 weeks and contained a mix of healthy individuals and those with clinical concerns. Single‐slice T1 and T2 mapping protocols were used to provide measurements in white matter, cortex, cerebellum, and deep gray matter. Automatic image segmentation of a separate T2‐weighted brain volume was used to define regions of interest for analysis. Results: Linear regression was used to estimate relaxation times at term equivalent age (40 weeks postmenstrual age). T140wk$$ {T}_1^{40 wk} $$ with 95% confidence intervals was measured to be 2933 [2893, 2972] ms in white matter; 2653 [2604, 2701] ms in cerebellum; and 2486 [2439, 2532] ms in basal ganglia. T240wk$$ {T}_2^{40 wk} $$ was estimated as 119 [116, 121] ms in white matter, 99 [96, 102] ms in cerebellum, and 90 [89, 92] ms in basal ganglia. Most tissue‐relaxation times showed a significant negative correlation with postmenstrual age, with the strongest correlation seen in cerebellum. Conclusions: We describe neonatal brain tissue and age‐specific T1 and T2 relaxation values at 7 T. The presented values differ substantially from both adult values at 7 T and neonate values measured at lower field strengths, and will be essential for pulse‐sequence optimization for neonatal studies. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: T<subscript>1</subscript> and T<subscript>2</subscript> measurements of the neonatal brain at 7 T.
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. May2025, Vol. 93 Issue 5, p2153-2162. 10p.
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  Data: Purpose: To determine the expected range of NMR relaxation times (T1 and T2) in the neonatal brain at 7 T. Methods: Data were acquired in a total of 40 examinations on infants in natural sleep. The cohort included 34 unique subjects with postmenstrual age range between 33 and 52 weeks and contained a mix of healthy individuals and those with clinical concerns. Single‐slice T1 and T2 mapping protocols were used to provide measurements in white matter, cortex, cerebellum, and deep gray matter. Automatic image segmentation of a separate T2‐weighted brain volume was used to define regions of interest for analysis. Results: Linear regression was used to estimate relaxation times at term equivalent age (40 weeks postmenstrual age). T140wk$$ {T}_1^{40 wk} $$ with 95% confidence intervals was measured to be 2933 [2893, 2972] ms in white matter; 2653 [2604, 2701] ms in cerebellum; and 2486 [2439, 2532] ms in basal ganglia. T240wk$$ {T}_2^{40 wk} $$ was estimated as 119 [116, 121] ms in white matter, 99 [96, 102] ms in cerebellum, and 90 [89, 92] ms in basal ganglia. Most tissue‐relaxation times showed a significant negative correlation with postmenstrual age, with the strongest correlation seen in cerebellum. Conclusions: We describe neonatal brain tissue and age‐specific T1 and T2 relaxation values at 7 T. The presented values differ substantially from both adult values at 7 T and neonate values measured at lower field strengths, and will be essential for pulse‐sequence optimization for neonatal studies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30403
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              Text: May2025
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