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Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation.

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Title: Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation.
Authors: Liang, Boxuan1 (AUTHOR), Huang, Xiyun1 (AUTHOR), Li, Zhiming1 (AUTHOR), Huang, Yuji1,2 (AUTHOR), Deng, Yanhong1 (AUTHOR), Chen, Xiaoqing1 (AUTHOR), Zhong, Yizhou1,2 (AUTHOR), Yang, Xiaohong1 (AUTHOR), Feng, Yu1 (AUTHOR), Bai, Ruobing1 (AUTHOR), Fan, Bingchi1 (AUTHOR), Xian, Hongyi1 (AUTHOR), Li, Hao1 (AUTHOR), Tang, Shiyue1 (AUTHOR), Huang, Zhenlie1,2 (AUTHOR) huangzhenlie858252@smu.edu.cn
Source: Environment International. Mar2025, Vol. 197, pN.PAG-N.PAG. 1p.
Subjects: Dietary patterns, Gastrointestinal system, Emerging contaminants, High-fat diet, Reactive oxygen species
Abstract: [Display omitted] • PS-NPs trigger ferroptosis in gut via ether phospholipid accumulation. • Nrf2 deficiency amplifies lipid peroxidation and ferroptosis susceptibility. • Ether phospholipid metabolism disruption drives ferroptosis in Nrf2 -deficient intestines. • High-fat diet exacerbates PS-NP-induced intestinal damage in Nrf2 -deficient mice. • Environmental PS-NP levels pose risks to individuals with impaired antioxidant defenses. The widespread environmental presence of nanoplastics (NPs) raises significant concerns about their health impacts, particularly on the gastrointestinal system, as NPs are primarily ingested. While previous studies have linked NP-induced intestinal toxicity to oxidative stress and reactive oxygen species (ROS) accumulation, the specific mechanisms of cell death remain unclear. Here, we showed that environmentally relevant concentrations of polystyrene nanoplastics (PS-NPs) induced ferroptosis, a form of lipid peroxidation-driven cell death, in intestinal epithelial cells. Using intestinal epithelial-specific Nrf2 -deficient mice (Nrf2fl/fl-VilCre+) and human intestinal epithelial Caco-2 cells, we demonstrated that Nrf2 , a key oxidative stress regulator, play a protective role against PS-NP-induced ferroptosis. PS-NP exposure disrupted ether phospholipid metabolism, leading to the accumulation of polyunsaturated fatty acid-ether phospholipids and heightened lipid peroxidation in the intestines of Nrf2fl/fl-VilCre+ mice. This accumulation increased the susceptibility of intestinal epithelial cells to ferroptosis. Additionally, a high-fat diet further exacerbated this effect, suggesting that individuals with reduced NRF2 activity and poor dietary habits may be especially vulnerable to PS-NP-induced intestinal damage. Our findings offered new insights into the molecular mechanisms of NP-induced intestinal toxicity and underscored the health risks posed by environmental PS-NP exposure, particularly in populations with compromised antioxidant defenses. [ABSTRACT FROM AUTHOR]
Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Data: Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation.
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  Data: <searchLink fieldCode="AR" term="%22Liang%2C+Boxuan%22">Liang, Boxuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Xiyun%22">Huang, Xiyun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Zhiming%22">Li, Zhiming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yuji%22">Huang, Yuji</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Yanhong%22">Deng, Yanhong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiaoqing%22">Chen, Xiaoqing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Yizhou%22">Zhong, Yizhou</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xiaohong%22">Yang, Xiaohong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Yu%22">Feng, Yu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bai%2C+Ruobing%22">Bai, Ruobing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan%2C+Bingchi%22">Fan, Bingchi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xian%2C+Hongyi%22">Xian, Hongyi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Hao%22">Li, Hao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Shiyue%22">Tang, Shiyue</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Zhenlie%22">Huang, Zhenlie</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> huangzhenlie858252@smu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Environment+International%22">Environment International</searchLink>. Mar2025, Vol. 197, pN.PAG-N.PAG. 1p.
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  Label: Abstract
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  Data: [Display omitted] • PS-NPs trigger ferroptosis in gut via ether phospholipid accumulation. • Nrf2 deficiency amplifies lipid peroxidation and ferroptosis susceptibility. • Ether phospholipid metabolism disruption drives ferroptosis in Nrf2 -deficient intestines. • High-fat diet exacerbates PS-NP-induced intestinal damage in Nrf2 -deficient mice. • Environmental PS-NP levels pose risks to individuals with impaired antioxidant defenses. The widespread environmental presence of nanoplastics (NPs) raises significant concerns about their health impacts, particularly on the gastrointestinal system, as NPs are primarily ingested. While previous studies have linked NP-induced intestinal toxicity to oxidative stress and reactive oxygen species (ROS) accumulation, the specific mechanisms of cell death remain unclear. Here, we showed that environmentally relevant concentrations of polystyrene nanoplastics (PS-NPs) induced ferroptosis, a form of lipid peroxidation-driven cell death, in intestinal epithelial cells. Using intestinal epithelial-specific Nrf2 -deficient mice (Nrf2fl/fl-VilCre+) and human intestinal epithelial Caco-2 cells, we demonstrated that Nrf2 , a key oxidative stress regulator, play a protective role against PS-NP-induced ferroptosis. PS-NP exposure disrupted ether phospholipid metabolism, leading to the accumulation of polyunsaturated fatty acid-ether phospholipids and heightened lipid peroxidation in the intestines of Nrf2fl/fl-VilCre+ mice. This accumulation increased the susceptibility of intestinal epithelial cells to ferroptosis. Additionally, a high-fat diet further exacerbated this effect, suggesting that individuals with reduced NRF2 activity and poor dietary habits may be especially vulnerable to PS-NP-induced intestinal damage. Our findings offered new insights into the molecular mechanisms of NP-induced intestinal toxicity and underscored the health risks posed by environmental PS-NP exposure, particularly in populations with compromised antioxidant defenses. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.envint.2025.109367
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      – Code: eng
        Text: English
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        StartPage: N.PAG
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      – SubjectFull: Dietary patterns
        Type: general
      – SubjectFull: Gastrointestinal system
        Type: general
      – SubjectFull: Emerging contaminants
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      – SubjectFull: High-fat diet
        Type: general
      – SubjectFull: Reactive oxygen species
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      – TitleFull: Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation.
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              Text: Mar2025
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