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Tris(pyronato)- and Tris(pyridonato)-ruthenium(III) Complexes and Solution NMR Studies.

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Title: Tris(pyronato)- and Tris(pyridonato)-ruthenium(III) Complexes and Solution NMR Studies.
Authors: Kennedy, David C.1, Wu, Adam1, Patrick, Brian O.1, James, Brian R.1 brj@chem.unc.ca
Source: Inorganic Chemistry. 9/19/2005, Vol. 44 Issue 19, p6529-6535. 8p. 4 Diagrams, 3 Charts, 2 Graphs.
Subjects: Ruthenium compounds, Ruthenium, Breast cancer, Cancer cells, Cell lines, Nuclear magnetic resonance, Electrochemical analysis, Physical & theoretical chemistry
Abstract: The water-soluble RuIII maltolato, ethylmaltolato, and pyridonato complexes, Ru(O-O′)3 (O-O′ = ma (1a), etma (1b), pyd (2a)), were synthesized (Hma = 3-hydroxy-2-methyl-4-pyrone, Hetma = 2-ethyl-3-hydroxy-4-pyrone, Hpyd = 3-hydroxy-1,2-dimethyl-4-pyridone). The complexes were characterized by elemental analysis, NMR and IR spectroscopies, MS, solution conductivity, and cyclic voltammetry, and in the case of Ru(ma)3, by X-ray crystallography, which revealed a met configuration. The paramagnetic 1H NMR resonances of 1a, 1b, and 2a were assigned using 2D methods (¹H COSY and ¹H-13C HMQC) and variable-temperature ¹H NMR data and showed that la and lb exist in aqueous solution predominantly as a mer isomer, while 2a is a mixture of mer and fac isomers. Although a 13C NMR spectrum could not be measured directly for la, a partial 13C spectrum was generated from the ¹H-13C HMQC spectrum. Complexes 1a and 1b were tested for anti-proliferatory activity against the human breast cancer cell line MDA-MB-435S and gave IC50 values of 140 and 90 μM, respectively. [ABSTRACT FROM AUTHOR]
Copyright of Inorganic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Tris(pyronato)- and Tris(pyridonato)-ruthenium(III) Complexes and Solution NMR Studies.
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  Data: <searchLink fieldCode="AR" term="%22Kennedy%2C+David+C%2E%22">Kennedy, David C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wu%2C+Adam%22">Wu, Adam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Patrick%2C+Brian+O%2E%22">Patrick, Brian O.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22James%2C+Brian+R%2E%22">James, Brian R.</searchLink><relatesTo>1</relatesTo><i> brj@chem.unc.ca</i>
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  Data: <searchLink fieldCode="JN" term="%22Inorganic+Chemistry%22">Inorganic Chemistry</searchLink>. 9/19/2005, Vol. 44 Issue 19, p6529-6535. 8p. 4 Diagrams, 3 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ruthenium+compounds%22">Ruthenium compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Ruthenium%22">Ruthenium</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer%22">Breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+lines%22">Cell lines</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance%22">Nuclear magnetic resonance</searchLink><br /><searchLink fieldCode="DE" term="%22Electrochemical+analysis%22">Electrochemical analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+%26+theoretical+chemistry%22">Physical & theoretical chemistry</searchLink>
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  Data: The water-soluble RuIII maltolato, ethylmaltolato, and pyridonato complexes, Ru(O-O′)3 (O-O′ = ma (1a), etma (1b), pyd (2a)), were synthesized (Hma = 3-hydroxy-2-methyl-4-pyrone, Hetma = 2-ethyl-3-hydroxy-4-pyrone, Hpyd = 3-hydroxy-1,2-dimethyl-4-pyridone). The complexes were characterized by elemental analysis, NMR and IR spectroscopies, MS, solution conductivity, and cyclic voltammetry, and in the case of Ru(ma)3, by X-ray crystallography, which revealed a met configuration. The paramagnetic 1H NMR resonances of 1a, 1b, and 2a were assigned using 2D methods (¹H COSY and ¹H-13C HMQC) and variable-temperature ¹H NMR data and showed that la and lb exist in aqueous solution predominantly as a mer isomer, while 2a is a mixture of mer and fac isomers. Although a 13C NMR spectrum could not be measured directly for la, a partial 13C spectrum was generated from the ¹H-13C HMQC spectrum. Complexes 1a and 1b were tested for anti-proliferatory activity against the human breast cancer cell line MDA-MB-435S and gave IC50 values of 140 and 90 μM, respectively. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Inorganic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Breast cancer
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      – SubjectFull: Nuclear magnetic resonance
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      – TitleFull: Tris(pyronato)- and Tris(pyridonato)-ruthenium(III) Complexes and Solution NMR Studies.
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              Text: 9/19/2005
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