Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints: Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments...: L. Walker et al.
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| Title: | Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints: Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments...: L. Walker et al. |
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| Authors: | Walker, Lizzie1 (AUTHOR) mewlkr@g.clemson.edu, Gordon, Daniel1 (AUTHOR) digordo@g.clemson.edu, Chiaramonti, Alexander2 (AUTHOR) achiaram@wakehealth.edu, Wang, Shangping1,3 (AUTHOR) shagpw@clemson.edu, Meng, Zhaoxu4 (AUTHOR) zmeng@clemson.edu, Daley, Dane3 (AUTHOR) dalda@musc.edu, Slate, Elizabeth5 (AUTHOR) eslate@fsu.edu, Yao, Hai1,3 (AUTHOR) haiyao@clemson.edu, Pellegrini Jr., Vincent D.6 (AUTHOR) vincent.d.pellegrini.jr@dartmouth.edu, Wu, Yongren1,3 (AUTHOR) yongren@clemson.edu |
| Source: | Annals of Biomedical Engineering. Apr2025, Vol. 53 Issue 4, p799-811. 13p. |
| Subjects: | Stress relaxation tests, Young's modulus, Strains & stresses (Mechanics), Scanning electron microscopy, Age groups |
| Abstract: | Purpose: To identify changes in morphological and mechanical properties in the volar ligament complex (VLC), dorsoradial ligaments (DRL), and posterior oblique ligaments (POL) in healthy and osteoarthritic female trapeziometacarpal (TMC) joints. Methods: Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Stress relaxation and load-to-failure testing were performed to characterize mechanical tensile properties. Light imaging and scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS) were performed to further assess enthesis structural integrity. Results: The VLC in advanced-stage osteoarthritic TMCs had attenuated mechanical properties in stress relaxation experiments compared to the elder healthy/early-stage osteoarthritic specimens: Young's modulus at 20% strain (P = 0.044), instantaneous (P = 0.023), relaxed (P = 0.017) moduli. VLCs in advanced-stage osteoarthritic TMCs also had significantly lower properties in the load-to-failure experiments compared to the younger healthy/early-stage osteoarthritic specimens: stiffness (P = 0.048), ultimate load (P = 0.017), toughness (P = 0.003). Light and SEM/EDS imaging revealed partial detachment and loss of enthesis mineral gradient at VLC metacarpal insertion in advanced-stage osteoarthritic specimens. There were no mechanical or structural changes in the DRL and POL between experiment groups. Conclusion: VLC morphological and mechanical properties deteriorate across progressively severe osteoarthritis classifications while the DRL and POL remain unchanged. The attenuated mechanical properties of VLCs in advanced-stage osteoarthritic TMCs can be explained by ligament degradation as evidenced by partial detachment and loss of mineral gradient at the metacarpal insertion. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 183973774 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints: Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments...: L. Walker et al. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Walker%2C+Lizzie%22">Walker, Lizzie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mewlkr@g.clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Gordon%2C+Daniel%22">Gordon, Daniel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> digordo@g.clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Chiaramonti%2C+Alexander%22">Chiaramonti, Alexander</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> achiaram@wakehealth.edu</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Shangping%22">Wang, Shangping</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> shagpw@clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Meng%2C+Zhaoxu%22">Meng, Zhaoxu</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> zmeng@clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Daley%2C+Dane%22">Daley, Dane</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> dalda@musc.edu</i><br /><searchLink fieldCode="AR" term="%22Slate%2C+Elizabeth%22">Slate, Elizabeth</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> eslate@fsu.edu</i><br /><searchLink fieldCode="AR" term="%22Yao%2C+Hai%22">Yao, Hai</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> haiyao@clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Pellegrini+Jr%2E%2C+Vincent+D%2E%22">Pellegrini Jr., Vincent D.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> vincent.d.pellegrini.jr@dartmouth.edu</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Yongren%22">Wu, Yongren</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> yongren@clemson.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Apr2025, Vol. 53 Issue 4, p799-811. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Stress+relaxation+tests%22">Stress relaxation tests</searchLink><br /><searchLink fieldCode="DE" term="%22Young's+modulus%22">Young's modulus</searchLink><br /><searchLink fieldCode="DE" term="%22Strains+%26+stresses+%28Mechanics%29%22">Strains & stresses (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Age+groups%22">Age groups</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To identify changes in morphological and mechanical properties in the volar ligament complex (VLC), dorsoradial ligaments (DRL), and posterior oblique ligaments (POL) in healthy and osteoarthritic female trapeziometacarpal (TMC) joints. Methods: Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Stress relaxation and load-to-failure testing were performed to characterize mechanical tensile properties. Light imaging and scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS) were performed to further assess enthesis structural integrity. Results: The VLC in advanced-stage osteoarthritic TMCs had attenuated mechanical properties in stress relaxation experiments compared to the elder healthy/early-stage osteoarthritic specimens: Young's modulus at 20% strain (P = 0.044), instantaneous (P = 0.023), relaxed (P = 0.017) moduli. VLCs in advanced-stage osteoarthritic TMCs also had significantly lower properties in the load-to-failure experiments compared to the younger healthy/early-stage osteoarthritic specimens: stiffness (P = 0.048), ultimate load (P = 0.017), toughness (P = 0.003). Light and SEM/EDS imaging revealed partial detachment and loss of enthesis mineral gradient at VLC metacarpal insertion in advanced-stage osteoarthritic specimens. There were no mechanical or structural changes in the DRL and POL between experiment groups. Conclusion: VLC morphological and mechanical properties deteriorate across progressively severe osteoarthritis classifications while the DRL and POL remain unchanged. The attenuated mechanical properties of VLCs in advanced-stage osteoarthritic TMCs can be explained by ligament degradation as evidenced by partial detachment and loss of mineral gradient at the metacarpal insertion. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-024-03660-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 799 Subjects: – SubjectFull: Stress relaxation tests Type: general – SubjectFull: Young's modulus Type: general – SubjectFull: Strains & stresses (Mechanics) Type: general – SubjectFull: Scanning electron microscopy Type: general – SubjectFull: Age groups Type: general Titles: – TitleFull: Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints: Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments...: L. Walker et al. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Walker, Lizzie – PersonEntity: Name: NameFull: Gordon, Daniel – PersonEntity: Name: NameFull: Chiaramonti, Alexander – PersonEntity: Name: NameFull: Wang, Shangping – PersonEntity: Name: NameFull: Meng, Zhaoxu – PersonEntity: Name: NameFull: Daley, Dane – PersonEntity: Name: NameFull: Slate, Elizabeth – PersonEntity: Name: NameFull: Yao, Hai – PersonEntity: Name: NameFull: Pellegrini Jr., Vincent D. – PersonEntity: Name: NameFull: Wu, Yongren IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 53 – Type: issue Value: 4 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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