Effects of anatomy and head motion on spatial patterns of deformation in the human brain: Effects of anatomy and head motion on spatial patterns of deformation...: J. D. Escarcega et al.
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| Title: | Effects of anatomy and head motion on spatial patterns of deformation in the human brain: Effects of anatomy and head motion on spatial patterns of deformation...: J. D. Escarcega et al. |
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| Authors: | Escarcega, Jordan D.1 (AUTHOR), Okamoto, Ruth J.1 (AUTHOR), Alshareef, Ahmed A.2 (AUTHOR), Johnson, Curtis L.3 (AUTHOR), Bayly, Philip V.1 (AUTHOR) pvb@wustl.edu |
| Source: | Annals of Biomedical Engineering. Apr2025, Vol. 53 Issue 4, p867-880. 14p. |
| Subjects: | Strain tensors, Tensor fields, Size of brain, Brain injuries, Brain anatomy |
| Abstract: | Purpose: To determine how the biomechanical vulnerability of the human brain is affected by features of individual anatomy and loading. Methods: To identify the features that contribute most to brain vulnerability, we imparted mild harmonic acceleration to the head and measured the resulting brain motion and deformation using magnetic resonance elastography (MRE). Oscillatory motion was imparted to the heads of adult participants using a lateral actuator (n = 24) or occipital actuator (n = 24) at 20 Hz, 30 Hz, and 50 Hz. Displacement vector fields and strain tensor fields in the brain were obtained from MRE measurements. Anatomical images, as well as displacement and strain fields from each participant were rigidly and deformably aligned to a common atlas (MNI-152). Vulnerability of the brain to deformation was quantified by the ratio of strain energy (SE) to kinetic energy (KE) for each participant. Similarity of deformation patterns between participants was quantified using strain field correlation (CV). Linear regression models were used to identify the effect of similarity of brain size, shape, and age, as well as similarity of loading, on CV. Results: The SE/KE ratio decreased with frequency and was larger for participants undergoing lateral, rather than occipital, actuation. Head rotation about the inferior–superior axis was correlated with larger SE/KE ratio. Strain field correlations were primarily affected by the similarity of rigid-body motion. Conclusion: The motion applied to the skull is the most important factor in determining both the vulnerability of the brain to deformation and the similarity between strain fields in different individuals. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of anatomy and head motion on spatial patterns of deformation in the human brain: Effects of anatomy and head motion on spatial patterns of deformation...: J. D. Escarcega et al. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Escarcega%2C+Jordan+D%2E%22">Escarcega, Jordan D.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Okamoto%2C+Ruth+J%2E%22">Okamoto, Ruth J.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alshareef%2C+Ahmed+A%2E%22">Alshareef, Ahmed A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johnson%2C+Curtis+L%2E%22">Johnson, Curtis L.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bayly%2C+Philip+V%2E%22">Bayly, Philip V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pvb@wustl.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Apr2025, Vol. 53 Issue 4, p867-880. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Strain+tensors%22">Strain tensors</searchLink><br /><searchLink fieldCode="DE" term="%22Tensor+fields%22">Tensor fields</searchLink><br /><searchLink fieldCode="DE" term="%22Size+of+brain%22">Size of brain</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To determine how the biomechanical vulnerability of the human brain is affected by features of individual anatomy and loading. Methods: To identify the features that contribute most to brain vulnerability, we imparted mild harmonic acceleration to the head and measured the resulting brain motion and deformation using magnetic resonance elastography (MRE). Oscillatory motion was imparted to the heads of adult participants using a lateral actuator (n = 24) or occipital actuator (n = 24) at 20 Hz, 30 Hz, and 50 Hz. Displacement vector fields and strain tensor fields in the brain were obtained from MRE measurements. Anatomical images, as well as displacement and strain fields from each participant were rigidly and deformably aligned to a common atlas (MNI-152). Vulnerability of the brain to deformation was quantified by the ratio of strain energy (SE) to kinetic energy (KE) for each participant. Similarity of deformation patterns between participants was quantified using strain field correlation (CV). Linear regression models were used to identify the effect of similarity of brain size, shape, and age, as well as similarity of loading, on CV. Results: The SE/KE ratio decreased with frequency and was larger for participants undergoing lateral, rather than occipital, actuation. Head rotation about the inferior–superior axis was correlated with larger SE/KE ratio. Strain field correlations were primarily affected by the similarity of rigid-body motion. Conclusion: The motion applied to the skull is the most important factor in determining both the vulnerability of the brain to deformation and the similarity between strain fields in different individuals. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-024-03671-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 867 Subjects: – SubjectFull: Strain tensors Type: general – SubjectFull: Tensor fields Type: general – SubjectFull: Size of brain Type: general – SubjectFull: Brain injuries Type: general – SubjectFull: Brain anatomy Type: general Titles: – TitleFull: Effects of anatomy and head motion on spatial patterns of deformation in the human brain: Effects of anatomy and head motion on spatial patterns of deformation...: J. D. Escarcega et al. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Escarcega, Jordan D. – PersonEntity: Name: NameFull: Okamoto, Ruth J. – PersonEntity: Name: NameFull: Alshareef, Ahmed A. – PersonEntity: Name: NameFull: Johnson, Curtis L. – PersonEntity: Name: NameFull: Bayly, Philip V. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 53 – Type: issue Value: 4 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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