3D MERMAID: 3D Multi‐shot enhanced recovery motion artifact insensitive diffusion for submillimeter, multi‐shell, and SNR‐efficient diffusion imaging.
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| Title: | 3D MERMAID: 3D Multi‐shot enhanced recovery motion artifact insensitive diffusion for submillimeter, multi‐shell, and SNR‐efficient diffusion imaging. |
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| Authors: | Feizollah, Sajjad1,2 (AUTHOR), Tardif, Christine L.1,2,3 (AUTHOR) christine.tardif@mcgill.ca |
| Source: | Magnetic Resonance in Medicine. Jun2025, Vol. 93 Issue 6, p2311-2330. 20p. |
| Subjects: | Diffusion magnetic resonance imaging, Graphical projection, Units of time, Image reconstruction, Compressed sensing |
| Abstract: | Purpose: To enhance SNR per unit time of diffusion MRI to enable high spatial resolution and extensive q‐sampling in a feasible scan time on clinical scanners. Methods: 3D multi‐shot enhanced recovery motion‐insensitive diffusion (MERMAID) consists of a whole brain nonselective 3D multi‐shot spin‐echo sequence with an inversion pulse immediately before the excitation pulse to enhance the recovery of longitudinal magnetization. The excitation flip angle is reduced to the Ernst angle. The sequence includes a trajectory using radially batched internal navigator echoes (TURBINE) readout, where a 3D projection of the FOV is acquired at a different radial angle in every shot. An image‐based phase‐correction method combined with compressed sensing image reconstruction was developed to correct phase errors between shots. The performance of the 3D MERMAID sequence was investigated using Bloch simulations as well as phantom and human scans at 3 T and then compared to a typical multi‐slice 2D spin‐echo sequence. Results: Improvements in SNR per unit time of 70%–240% were observed in phantom and human scans when using 3D MERMAID compared to a single‐slice 2D spin‐echo sequence. This SNR per unit time improvement allowed scans to be acquired at a nominal isotropic resolution of 0.74 mm and a total of 112 directions across four shells (b = 150, 300, 1000, 2000 s/mm2) in 37 min on a clinical scanner. Conclusion: The 3D MERMAID sequence was shown to significantly improve SNR per unit time compared to multi‐slice 2D and 3D diffusion sequences. This SNR improvement allows for shorter scan times and higher spatial and angular resolutions on clinical scanners. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 184274801 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 3D MERMAID: 3D Multi‐shot enhanced recovery motion artifact insensitive diffusion for submillimeter, multi‐shell, and SNR‐efficient diffusion imaging. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Feizollah%2C+Sajjad%22">Feizollah, Sajjad</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tardif%2C+Christine+L%2E%22">Tardif, Christine L.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> christine.tardif@mcgill.ca</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jun2025, Vol. 93 Issue 6, p2311-2330. 20p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diffusion+magnetic+resonance+imaging%22">Diffusion magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Graphical+projection%22">Graphical projection</searchLink><br /><searchLink fieldCode="DE" term="%22Units+of+time%22">Units of time</searchLink><br /><searchLink fieldCode="DE" term="%22Image+reconstruction%22">Image reconstruction</searchLink><br /><searchLink fieldCode="DE" term="%22Compressed+sensing%22">Compressed sensing</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To enhance SNR per unit time of diffusion MRI to enable high spatial resolution and extensive q‐sampling in a feasible scan time on clinical scanners. Methods: 3D multi‐shot enhanced recovery motion‐insensitive diffusion (MERMAID) consists of a whole brain nonselective 3D multi‐shot spin‐echo sequence with an inversion pulse immediately before the excitation pulse to enhance the recovery of longitudinal magnetization. The excitation flip angle is reduced to the Ernst angle. The sequence includes a trajectory using radially batched internal navigator echoes (TURBINE) readout, where a 3D projection of the FOV is acquired at a different radial angle in every shot. An image‐based phase‐correction method combined with compressed sensing image reconstruction was developed to correct phase errors between shots. The performance of the 3D MERMAID sequence was investigated using Bloch simulations as well as phantom and human scans at 3 T and then compared to a typical multi‐slice 2D spin‐echo sequence. Results: Improvements in SNR per unit time of 70%–240% were observed in phantom and human scans when using 3D MERMAID compared to a single‐slice 2D spin‐echo sequence. This SNR per unit time improvement allowed scans to be acquired at a nominal isotropic resolution of 0.74 mm and a total of 112 directions across four shells (b = 150, 300, 1000, 2000 s/mm2) in 37 min on a clinical scanner. Conclusion: The 3D MERMAID sequence was shown to significantly improve SNR per unit time compared to multi‐slice 2D and 3D diffusion sequences. This SNR improvement allows for shorter scan times and higher spatial and angular resolutions on clinical scanners. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30436 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 2311 Subjects: – SubjectFull: Diffusion magnetic resonance imaging Type: general – SubjectFull: Graphical projection Type: general – SubjectFull: Units of time Type: general – SubjectFull: Image reconstruction Type: general – SubjectFull: Compressed sensing Type: general Titles: – TitleFull: 3D MERMAID: 3D Multi‐shot enhanced recovery motion artifact insensitive diffusion for submillimeter, multi‐shell, and SNR‐efficient diffusion imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Feizollah, Sajjad – PersonEntity: Name: NameFull: Tardif, Christine L. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 93 – Type: issue Value: 6 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
