In Vivo Degradation Behavior of AZ91 Magnesium Alloy: Comprehensive Microstructural and Crystallographic Characterization by TEM and NBED.
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| Title: | In Vivo Degradation Behavior of AZ91 Magnesium Alloy: Comprehensive Microstructural and Crystallographic Characterization by TEM and NBED. |
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| Authors: | Liu, Zhichao1,2 (AUTHOR), Yue, Honglei1,2 (AUTHOR), Zhu, Jianhua3 (AUTHOR), Han, Jianmin4,5 (AUTHOR) |
| Source: | Materials (1996-1944). Apr2025, Vol. 18 Issue 7, p1500. 15p. |
| Subjects: | Laboratory rats, Electron microscope techniques, Bioabsorbable implants, Layered double hydroxides, Calcium phosphate, Biodegradable materials |
| Abstract: | Magnesium alloys have attracted significant attention in recent years as biodegradable metals. However, their degradation mechanisms in vivo remain insufficiently understood. The present work investigates the degradation mechanism of AZ91 magnesium alloy in a critical-size rat defect model over an 8-week period in vivo, employing advanced characterization techniques such as transmission electron microscopy (TEM) and nanobeam electron diffraction (NBED). The degradation layer is observed to consist of three distinct sub-layers: a dense and compact poor crystallinity layer (PCL) layer primarily composed of calcium phosphate, a loose and porous amorphous layer (AL) of magnesium/calcium phosphate, and a hybrid layer (HL)layer containing degradation channels and composed of magnesium/calcium phosphate, layered double hydroxide (LDH), and magnesium hydroxide. The corrosion resistance of AZ91 is enhanced by the presence of the compact PCL layer, the uniform distribution of the Mg17Al12 phase, and the formation of impervious LDH at the corrosion interface. The degradation is primarily driven by micro-galvanic corrosion, which is influenced by the interaction between the Mg matrix and the Mg17Al12 phase. These findings provide critical insights into the stable degradation mechanism of Mg-Al alloys in vivo, advancing the development of biodegradable magnesium-based implants. [ABSTRACT FROM AUTHOR] |
| Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 184439892 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In Vivo Degradation Behavior of AZ91 Magnesium Alloy: Comprehensive Microstructural and Crystallographic Characterization by TEM and NBED. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Liu%2C+Zhichao%22">Liu, Zhichao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yue%2C+Honglei%22">Yue, Honglei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Jianhua%22">Zhu, Jianhua</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Jianmin%22">Han, Jianmin</searchLink><relatesTo>4,5</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Materials+%281996-1944%29%22">Materials (1996-1944)</searchLink>. Apr2025, Vol. 18 Issue 7, p1500. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Electron+microscope+techniques%22">Electron microscope techniques</searchLink><br /><searchLink fieldCode="DE" term="%22Bioabsorbable+implants%22">Bioabsorbable implants</searchLink><br /><searchLink fieldCode="DE" term="%22Layered+double+hydroxides%22">Layered double hydroxides</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+materials%22">Biodegradable materials</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Magnesium alloys have attracted significant attention in recent years as biodegradable metals. However, their degradation mechanisms in vivo remain insufficiently understood. The present work investigates the degradation mechanism of AZ91 magnesium alloy in a critical-size rat defect model over an 8-week period in vivo, employing advanced characterization techniques such as transmission electron microscopy (TEM) and nanobeam electron diffraction (NBED). The degradation layer is observed to consist of three distinct sub-layers: a dense and compact poor crystallinity layer (PCL) layer primarily composed of calcium phosphate, a loose and porous amorphous layer (AL) of magnesium/calcium phosphate, and a hybrid layer (HL)layer containing degradation channels and composed of magnesium/calcium phosphate, layered double hydroxide (LDH), and magnesium hydroxide. The corrosion resistance of AZ91 is enhanced by the presence of the compact PCL layer, the uniform distribution of the Mg17Al12 phase, and the formation of impervious LDH at the corrosion interface. The degradation is primarily driven by micro-galvanic corrosion, which is influenced by the interaction between the Mg matrix and the Mg17Al12 phase. These findings provide critical insights into the stable degradation mechanism of Mg-Al alloys in vivo, advancing the development of biodegradable magnesium-based implants. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/ma18071500 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1500 Subjects: – SubjectFull: Laboratory rats Type: general – SubjectFull: Electron microscope techniques Type: general – SubjectFull: Bioabsorbable implants Type: general – SubjectFull: Layered double hydroxides Type: general – SubjectFull: Calcium phosphate Type: general – SubjectFull: Biodegradable materials Type: general Titles: – TitleFull: In Vivo Degradation Behavior of AZ91 Magnesium Alloy: Comprehensive Microstructural and Crystallographic Characterization by TEM and NBED. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Liu, Zhichao – PersonEntity: Name: NameFull: Yue, Honglei – PersonEntity: Name: NameFull: Zhu, Jianhua – PersonEntity: Name: NameFull: Han, Jianmin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 19961944 Numbering: – Type: volume Value: 18 – Type: issue Value: 7 Titles: – TitleFull: Materials (1996-1944) Type: main |
| ResultId | 1 |
