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Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells.

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Title: Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells.
Authors: Zhang, Yin-Di1,2 (AUTHOR), Liu, Jun-Xi1,2,3 (AUTHOR), Wang, Fei-Fei1,2,3 (AUTHOR), Qu, Li-Ping1,2,3 (AUTHOR) quliping0586@126.com, Rebollo-Hernanz, Miguel (AUTHOR)
Source: Journal of Food Biochemistry. 4/26/2025, Vol. 2025, p1-18. 18p.
Subjects: Lipid metabolism disorders, Glucose metabolism disorders, Treatment effectiveness, Lipid metabolism, Insulin resistance
Abstract: Various diseases caused by disorders of glucose and lipid metabolism are increasing day by day. Although many drugs have certain therapeutic effects, they still produce some side effects. Therefore, this article chooses the natural medicinal plant mulberry leaves to reveal its mechanism of regulating glucose and lipid metabolism. By establishing an insulin resistance model and a 3T3‐L1 adipocyte model, it was found that mulberry leaf extract (MLE) and deoxynojirimycin (DNJ) significantly increased glucose consumption and glycogen consumption, while reducing total cholesterol (TC), triglycerides (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels. Network pharmacology, molecular docking, and protein level showed that MLE and DNJ could improve glucose and lipid metabolism disorders through IRS1/PI3K/AKT signaling pathway. These results suggest that MLE and DNJ may have broad application prospects in regulating glycolipid metabolism in functional foods and healthcare products. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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An: 184767240
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  Label: Title
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  Data: Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Yin-Di%22">Zhang, Yin-Di</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jun-Xi%22">Liu, Jun-Xi</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Fei-Fei%22">Wang, Fei-Fei</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qu%2C+Li-Ping%22">Qu, Li-Ping</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> quliping0586@126.com</i><br /><searchLink fieldCode="AR" term="%22Rebollo-Hernanz%2C+Miguel%22">Rebollo-Hernanz, Miguel</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 4/26/2025, Vol. 2025, p1-18. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Lipid+metabolism+disorders%22">Lipid metabolism disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+metabolism+disorders%22">Glucose metabolism disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+resistance%22">Insulin resistance</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Various diseases caused by disorders of glucose and lipid metabolism are increasing day by day. Although many drugs have certain therapeutic effects, they still produce some side effects. Therefore, this article chooses the natural medicinal plant mulberry leaves to reveal its mechanism of regulating glucose and lipid metabolism. By establishing an insulin resistance model and a 3T3‐L1 adipocyte model, it was found that mulberry leaf extract (MLE) and deoxynojirimycin (DNJ) significantly increased glucose consumption and glycogen consumption, while reducing total cholesterol (TC), triglycerides (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels. Network pharmacology, molecular docking, and protein level showed that MLE and DNJ could improve glucose and lipid metabolism disorders through IRS1/PI3K/AKT signaling pathway. These results suggest that MLE and DNJ may have broad application prospects in regulating glycolipid metabolism in functional foods and healthcare products. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1155/jfbc/7345044
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      – Code: eng
        Text: English
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        PageCount: 18
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      – SubjectFull: Lipid metabolism disorders
        Type: general
      – SubjectFull: Glucose metabolism disorders
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Lipid metabolism
        Type: general
      – SubjectFull: Insulin resistance
        Type: general
    Titles:
      – TitleFull: Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells.
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            NameFull: Zhang, Yin-Di
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            NameFull: Liu, Jun-Xi
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            NameFull: Wang, Fei-Fei
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            NameFull: Qu, Li-Ping
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            NameFull: Rebollo-Hernanz, Miguel
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              M: 04
              Text: 4/26/2025
              Type: published
              Y: 2025
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              Value: 2025
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