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Formaldehyde‐Enabled Enzymatic Hydroxymethylation for the Synthesis of High Value‐Added Multifunctional Compounds.

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Title: Formaldehyde‐Enabled Enzymatic Hydroxymethylation for the Synthesis of High Value‐Added Multifunctional Compounds.
Authors: Li, Yu1 (AUTHOR), Fan, Yue1,2,3 (AUTHOR), Yao, Peiyuan1 (AUTHOR), Wu, Qiaqing1 (AUTHOR) wu_qq@tib.cas.cn, Zhu, Dunming1 (AUTHOR) zhu_dm@tib.cas.cn
Source: ChemCatChem. 5/8/2025, Vol. 17 Issue 9, p1-19. 19p.
Subjects: Aldolases, Complex compounds, Organic synthesis, Formaldehyde, Enzymes, Thiamin pyrophosphate
Abstract: Given the importance of multifunctional compounds and the versatile reactivity of one‐carbon (C1) molecule formaldehyde, the synthesis of value‐added multifunctional compounds from formaldehyde and other simple molecules via C─C bond formation has been the focus of intensive investigations. In view of the uncontrollable reactivity of formaldehyde, the employment of formaldehyde in the C─C bond formation is considered as one of the most challenging tasks in organic synthesis. Aldolases and thiamine pyrophosphate (ThDP)‐dependent enzymes have been regarded as the most potential biocatalytic tools for carbon–carbon (C─C) bond formation. In the present review, aldolases and ThDP‐dependent enzymes are shown to be the simplest and powerful biocatalytic platforms for controlling the reactivity of formaldehyde to effectively produce multifunctional compounds. The recent advances in the construction of multienzymatic cascade reactions for the synthesis of complex multifunctional compounds from formaldehyde via C─C bond formation have also been presented. [ABSTRACT FROM AUTHOR]
Copyright of ChemCatChem is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Formaldehyde‐Enabled Enzymatic Hydroxymethylation for the Synthesis of High Value‐Added Multifunctional Compounds.
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  Data: <searchLink fieldCode="JN" term="%22ChemCatChem%22">ChemCatChem</searchLink>. 5/8/2025, Vol. 17 Issue 9, p1-19. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Aldolases%22">Aldolases</searchLink><br /><searchLink fieldCode="DE" term="%22Complex+compounds%22">Complex compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+synthesis%22">Organic synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Formaldehyde%22">Formaldehyde</searchLink><br /><searchLink fieldCode="DE" term="%22Enzymes%22">Enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Thiamin+pyrophosphate%22">Thiamin pyrophosphate</searchLink>
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  Data: Given the importance of multifunctional compounds and the versatile reactivity of one‐carbon (C1) molecule formaldehyde, the synthesis of value‐added multifunctional compounds from formaldehyde and other simple molecules via C─C bond formation has been the focus of intensive investigations. In view of the uncontrollable reactivity of formaldehyde, the employment of formaldehyde in the C─C bond formation is considered as one of the most challenging tasks in organic synthesis. Aldolases and thiamine pyrophosphate (ThDP)‐dependent enzymes have been regarded as the most potential biocatalytic tools for carbon–carbon (C─C) bond formation. In the present review, aldolases and ThDP‐dependent enzymes are shown to be the simplest and powerful biocatalytic platforms for controlling the reactivity of formaldehyde to effectively produce multifunctional compounds. The recent advances in the construction of multienzymatic cascade reactions for the synthesis of complex multifunctional compounds from formaldehyde via C─C bond formation have also been presented. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of ChemCatChem is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/cctc.202402005
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      – Code: eng
        Text: English
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      – SubjectFull: Aldolases
        Type: general
      – SubjectFull: Complex compounds
        Type: general
      – SubjectFull: Organic synthesis
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      – SubjectFull: Formaldehyde
        Type: general
      – SubjectFull: Enzymes
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      – SubjectFull: Thiamin pyrophosphate
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      – TitleFull: Formaldehyde‐Enabled Enzymatic Hydroxymethylation for the Synthesis of High Value‐Added Multifunctional Compounds.
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            NameFull: Fan, Yue
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            NameFull: Yao, Peiyuan
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            NameFull: Wu, Qiaqing
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            NameFull: Zhu, Dunming
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              Text: 5/8/2025
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              Y: 2025
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