Innovative Sericin-Based Film-Forming Gel for Wound Healing: Development and Performance Evaluation.
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| Title: | Innovative Sericin-Based Film-Forming Gel for Wound Healing: Development and Performance Evaluation. |
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| Authors: | Wongtechanon, Suprawee1,2 (AUTHOR), Noosak, Chayanee1,2,3 (AUTHOR), Jantorn, Pavarish1,3 (AUTHOR), Watcharanurak, Papitchaya1 (AUTHOR), Swangphon, Piyawut1,2 (AUTHOR), Wanna, Warapond2,3 (AUTHOR), Sotthibandhu, Dennapa Saeloh1 (AUTHOR) dennapa.sa@psu.ac.th |
| Source: | Polymers (20734360). May2025, Vol. 17 Issue 9, p1246. 15p. |
| Subjects: | Polyvinyl alcohol, Sericin, Chronic wounds & injuries, Cell migration, Therapeutics, Wound healing |
| Abstract: | The development of effective wound dressings remains a critical challenge in medical treatments, requiring materials that promote healing, minimize infection, and enhance tissue regeneration. This study evaluated the wound-healing potential of sericin-based film-forming gels. Six formulations were developed by combining varying concentrations of sericin, a protein derived from silk cocoons, with polyvinyl alcohol (PVA). These formulations were evaluated for physical properties including drying time, pH, spreadability, stability, swelling ratio, flexibility, and adhesion. Film-forming gel is an attractive option for wound dressing due to its flexibility, adhesion, and infrequent reapplication. The F4 formulation (1% sericin) demonstrated superior performances in drying time, spreadability, stability, swelling ratio, flexibility, and skin adhesion, was easy to apply, and formed a stable film on drying. Biological evaluations showed that F4 exhibited excellent compatibility with skin fibroblast cells, maintained a suitable pH, and significantly promoted cell proliferation and migration. The F4 formulation also demonstrated anti-inflammatory effects by inhibiting iNOS expression and nitric oxide production, offering mechanical stability, biological activity, and ease of use with significant potential for treating acute and chronic wounds. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | The development of effective wound dressings remains a critical challenge in medical treatments, requiring materials that promote healing, minimize infection, and enhance tissue regeneration. This study evaluated the wound-healing potential of sericin-based film-forming gels. Six formulations were developed by combining varying concentrations of sericin, a protein derived from silk cocoons, with polyvinyl alcohol (PVA). These formulations were evaluated for physical properties including drying time, pH, spreadability, stability, swelling ratio, flexibility, and adhesion. Film-forming gel is an attractive option for wound dressing due to its flexibility, adhesion, and infrequent reapplication. The F4 formulation (1% sericin) demonstrated superior performances in drying time, spreadability, stability, swelling ratio, flexibility, and skin adhesion, was easy to apply, and formed a stable film on drying. Biological evaluations showed that F4 exhibited excellent compatibility with skin fibroblast cells, maintained a suitable pH, and significantly promoted cell proliferation and migration. The F4 formulation also demonstrated anti-inflammatory effects by inhibiting iNOS expression and nitric oxide production, offering mechanical stability, biological activity, and ease of use with significant potential for treating acute and chronic wounds. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20734360 |
| DOI: | 10.3390/polym17091246 |
