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Innovative Sericin-Based Film-Forming Gel for Wound Healing: Development and Performance Evaluation.

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Title: Innovative Sericin-Based Film-Forming Gel for Wound Healing: Development and Performance Evaluation.
Authors: Wongtechanon, Suprawee1,2 (AUTHOR), Noosak, Chayanee1,2,3 (AUTHOR), Jantorn, Pavarish1,3 (AUTHOR), Watcharanurak, Papitchaya1 (AUTHOR), Swangphon, Piyawut1,2 (AUTHOR), Wanna, Warapond2,3 (AUTHOR), Sotthibandhu, Dennapa Saeloh1 (AUTHOR) dennapa.sa@psu.ac.th
Source: Polymers (20734360). May2025, Vol. 17 Issue 9, p1246. 15p.
Subjects: Polyvinyl alcohol, Sericin, Chronic wounds & injuries, Cell migration, Therapeutics, Wound healing
Abstract: The development of effective wound dressings remains a critical challenge in medical treatments, requiring materials that promote healing, minimize infection, and enhance tissue regeneration. This study evaluated the wound-healing potential of sericin-based film-forming gels. Six formulations were developed by combining varying concentrations of sericin, a protein derived from silk cocoons, with polyvinyl alcohol (PVA). These formulations were evaluated for physical properties including drying time, pH, spreadability, stability, swelling ratio, flexibility, and adhesion. Film-forming gel is an attractive option for wound dressing due to its flexibility, adhesion, and infrequent reapplication. The F4 formulation (1% sericin) demonstrated superior performances in drying time, spreadability, stability, swelling ratio, flexibility, and skin adhesion, was easy to apply, and formed a stable film on drying. Biological evaluations showed that F4 exhibited excellent compatibility with skin fibroblast cells, maintained a suitable pH, and significantly promoted cell proliferation and migration. The F4 formulation also demonstrated anti-inflammatory effects by inhibiting iNOS expression and nitric oxide production, offering mechanical stability, biological activity, and ease of use with significant potential for treating acute and chronic wounds. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Innovative Sericin-Based Film-Forming Gel for Wound Healing: Development and Performance Evaluation.
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. May2025, Vol. 17 Issue 9, p1246. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Polyvinyl+alcohol%22">Polyvinyl alcohol</searchLink><br /><searchLink fieldCode="DE" term="%22Sericin%22">Sericin</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+wounds+%26+injuries%22">Chronic wounds & injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+migration%22">Cell migration</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink>
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  Data: The development of effective wound dressings remains a critical challenge in medical treatments, requiring materials that promote healing, minimize infection, and enhance tissue regeneration. This study evaluated the wound-healing potential of sericin-based film-forming gels. Six formulations were developed by combining varying concentrations of sericin, a protein derived from silk cocoons, with polyvinyl alcohol (PVA). These formulations were evaluated for physical properties including drying time, pH, spreadability, stability, swelling ratio, flexibility, and adhesion. Film-forming gel is an attractive option for wound dressing due to its flexibility, adhesion, and infrequent reapplication. The F4 formulation (1% sericin) demonstrated superior performances in drying time, spreadability, stability, swelling ratio, flexibility, and skin adhesion, was easy to apply, and formed a stable film on drying. Biological evaluations showed that F4 exhibited excellent compatibility with skin fibroblast cells, maintained a suitable pH, and significantly promoted cell proliferation and migration. The F4 formulation also demonstrated anti-inflammatory effects by inhibiting iNOS expression and nitric oxide production, offering mechanical stability, biological activity, and ease of use with significant potential for treating acute and chronic wounds. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/polym17091246
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        Text: English
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        PageCount: 15
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        Type: general
      – SubjectFull: Sericin
        Type: general
      – SubjectFull: Chronic wounds & injuries
        Type: general
      – SubjectFull: Cell migration
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Wound healing
        Type: general
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      – TitleFull: Innovative Sericin-Based Film-Forming Gel for Wound Healing: Development and Performance Evaluation.
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              M: 05
              Text: May2025
              Type: published
              Y: 2025
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