Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies.
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| Title: | Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies. |
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| Authors: | Riaz, Shumaila1 (AUTHOR), Ali, Shaukat1 (AUTHOR) dr.shaukatali@gcu.edu.pk, Summer, Muhammad1 (AUTHOR) muhammad.summer@gcu.edu.pk, Akhtar, Urva1 (AUTHOR), Noor, Shehzeen1 (AUTHOR), Haqqi, Rimsha1 (AUTHOR), Farooq, Muhammad Adeel1 (AUTHOR), Sardar, Iqra1 (AUTHOR) |
| Source: | Annals of Biomedical Engineering. Jun2025, Vol. 53 Issue 6, p1291-1327. 37p. |
| Subjects: | Targeted drug delivery, Drug delivery systems, Biomedical engineering, Controlled release drugs, Magnetic nanoparticles |
| Abstract: | Magnetic nanoparticles (MNPs) have revolutionized cancer therapy by serving as effective drug transporters through active and passive targeting of tumor sites in conjugation with external alternating magnetic fields (AMFs), thus minimizing off-target effects. This precise targeting strategy guarantees a focused and controlled drug release at the tumor site, reducing the drawbacks of standard drug delivery systems and enhancing treatment effectiveness. Magnetic nanoparticles usually follow in magnetic hyperthermia (MHT) therapy, where AMFs raise the temperature at the tumor site, efficiently eliminating cancer cells and presenting a hopeful complement to conventional cancer treatments. In addition, side effects are reduced by launching a smart drug delivery system (SDDSs) in which treatment efficacy is enhanced by reducing the dosage frequency. Intrinsic properties of MNPs are measured when they serve as contrast agents in magnetic resonance imaging (MRI), providing a diagnostic aspect to their therapeutic capabilities and enabling medical professionals to monitor and record treatment outcomes with precision and higher accuracy. This comprehensive review highlights the multifaceted potential of MNPs in reshaping cancer treatment, emphasizing their role in targeted drug delivery, hyperthermia therapy, and imaging applications, and underscoring their transformative impact on the future of oncological care. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 185134752 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Riaz%2C+Shumaila%22">Riaz, Shumaila</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Shaukat%22">Ali, Shaukat</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dr.shaukatali@gcu.edu.pk</i><br /><searchLink fieldCode="AR" term="%22Summer%2C+Muhammad%22">Summer, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> muhammad.summer@gcu.edu.pk</i><br /><searchLink fieldCode="AR" term="%22Akhtar%2C+Urva%22">Akhtar, Urva</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Noor%2C+Shehzeen%22">Noor, Shehzeen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haqqi%2C+Rimsha%22">Haqqi, Rimsha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farooq%2C+Muhammad+Adeel%22">Farooq, Muhammad Adeel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sardar%2C+Iqra%22">Sardar, Iqra</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jun2025, Vol. 53 Issue 6, p1291-1327. 37p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+engineering%22">Biomedical engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+nanoparticles%22">Magnetic nanoparticles</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Magnetic nanoparticles (MNPs) have revolutionized cancer therapy by serving as effective drug transporters through active and passive targeting of tumor sites in conjugation with external alternating magnetic fields (AMFs), thus minimizing off-target effects. This precise targeting strategy guarantees a focused and controlled drug release at the tumor site, reducing the drawbacks of standard drug delivery systems and enhancing treatment effectiveness. Magnetic nanoparticles usually follow in magnetic hyperthermia (MHT) therapy, where AMFs raise the temperature at the tumor site, efficiently eliminating cancer cells and presenting a hopeful complement to conventional cancer treatments. In addition, side effects are reduced by launching a smart drug delivery system (SDDSs) in which treatment efficacy is enhanced by reducing the dosage frequency. Intrinsic properties of MNPs are measured when they serve as contrast agents in magnetic resonance imaging (MRI), providing a diagnostic aspect to their therapeutic capabilities and enabling medical professionals to monitor and record treatment outcomes with precision and higher accuracy. This comprehensive review highlights the multifaceted potential of MNPs in reshaping cancer treatment, emphasizing their role in targeted drug delivery, hyperthermia therapy, and imaging applications, and underscoring their transformative impact on the future of oncological care. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-025-03712-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 37 StartPage: 1291 Subjects: – SubjectFull: Targeted drug delivery Type: general – SubjectFull: Drug delivery systems Type: general – SubjectFull: Biomedical engineering Type: general – SubjectFull: Controlled release drugs Type: general – SubjectFull: Magnetic nanoparticles Type: general Titles: – TitleFull: Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Riaz, Shumaila – PersonEntity: Name: NameFull: Ali, Shaukat – PersonEntity: Name: NameFull: Summer, Muhammad – PersonEntity: Name: NameFull: Akhtar, Urva – PersonEntity: Name: NameFull: Noor, Shehzeen – PersonEntity: Name: NameFull: Haqqi, Rimsha – PersonEntity: Name: NameFull: Farooq, Muhammad Adeel – PersonEntity: Name: NameFull: Sardar, Iqra IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 53 – Type: issue Value: 6 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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