A Regional Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints.
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| Title: | A Regional Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints. |
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| Authors: | Walker, Lizzie1 (AUTHOR) mewlkr@g.clemson.edu, Li, Hui1 (AUTHOR) hui3@g.clemson.edu, Buchweitz, Nathan1 (AUTHOR) nbuchwe@g.clemson.edu, Gordon, Daniel1 (AUTHOR) digordo@g.clemson.edu, Wang, Shangping1,2 (AUTHOR) shangpw@clemson.edu, Daley, Dane2 (AUTHOR) dalda@musc.edu, Yao, Hai1,2 (AUTHOR) haiyao@clemson.edu, Wu, Yongren1,2 (AUTHOR) yongren@clemson.edu |
| Source: | Annals of Biomedical Engineering. Jun2025, Vol. 53 Issue 6, p1471-1485. 15p. |
| Subjects: | Articular ligaments, Articular cartilage, Magnetic resonance imaging, Medical sciences, Scanning electron microscopy |
| Abstract: | Purpose: To identify the mechanical and morphological regional changes of articular cartilage on the first metacarpal and trapezium and their association with attenuation of the volar ligament complex (VLC) during trapeziometacarpal (TMC) osteoarthritis (OA) progression. Methods: Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Metacarpal and trapezium surfaces were split into six regions. Microindentation testing was performed to characterize the biphasic properties of each region. Light imaging, scanning electron microscopy/energy dispersive spectroscopy, and magnetic resonance imaging were performed to assess cartilage integrity and identify wear patterns. Results: The volar ulnar region of the metacarpal, along with the volar central and volar ulnar regions of the trapezium, had a higher equilibrium modulus in the advanced-stage OA specimens. SEM/EDS revealed these regions to be fully eburnated in most cases. MRI revealed eburnation, as well as the degeneration and/or detachment of the beak ligament portion of the VLC. In the advanced-stage OA TMCs, an increased equilibrium modulus in the volar portion of the trapezium correlates to attenuated VLC stiffness from our previous study. Conclusion: A regional pattern in articular cartilage degeneration, including changes in biphasic properties evidenced by an increased equilibrium modulus, during TMC OA progression is evident with the most significant changes occurring in the volar ulnar region of the metacarpal and volar central and volar ulnar regions of the trapezium. These changes in articular cartilage can be correlated to an attenuated VLC. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 185134759 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Regional Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Walker%2C+Lizzie%22">Walker, Lizzie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mewlkr@g.clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Hui%22">Li, Hui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hui3@g.clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Buchweitz%2C+Nathan%22">Buchweitz, Nathan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> nbuchwe@g.clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Gordon%2C+Daniel%22">Gordon, Daniel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> digordo@g.clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Shangping%22">Wang, Shangping</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> shangpw@clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Daley%2C+Dane%22">Daley, Dane</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> dalda@musc.edu</i><br /><searchLink fieldCode="AR" term="%22Yao%2C+Hai%22">Yao, Hai</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> haiyao@clemson.edu</i><br /><searchLink fieldCode="AR" term="%22Wu%2C+Yongren%22">Wu, Yongren</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> yongren@clemson.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jun2025, Vol. 53 Issue 6, p1471-1485. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Articular+ligaments%22">Articular ligaments</searchLink><br /><searchLink fieldCode="DE" term="%22Articular+cartilage%22">Articular cartilage</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To identify the mechanical and morphological regional changes of articular cartilage on the first metacarpal and trapezium and their association with attenuation of the volar ligament complex (VLC) during trapeziometacarpal (TMC) osteoarthritis (OA) progression. Methods: Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Metacarpal and trapezium surfaces were split into six regions. Microindentation testing was performed to characterize the biphasic properties of each region. Light imaging, scanning electron microscopy/energy dispersive spectroscopy, and magnetic resonance imaging were performed to assess cartilage integrity and identify wear patterns. Results: The volar ulnar region of the metacarpal, along with the volar central and volar ulnar regions of the trapezium, had a higher equilibrium modulus in the advanced-stage OA specimens. SEM/EDS revealed these regions to be fully eburnated in most cases. MRI revealed eburnation, as well as the degeneration and/or detachment of the beak ligament portion of the VLC. In the advanced-stage OA TMCs, an increased equilibrium modulus in the volar portion of the trapezium correlates to attenuated VLC stiffness from our previous study. Conclusion: A regional pattern in articular cartilage degeneration, including changes in biphasic properties evidenced by an increased equilibrium modulus, during TMC OA progression is evident with the most significant changes occurring in the volar ulnar region of the metacarpal and volar central and volar ulnar regions of the trapezium. These changes in articular cartilage can be correlated to an attenuated VLC. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-025-03726-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1471 Subjects: – SubjectFull: Articular ligaments Type: general – SubjectFull: Articular cartilage Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Medical sciences Type: general – SubjectFull: Scanning electron microscopy Type: general Titles: – TitleFull: A Regional Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Walker, Lizzie – PersonEntity: Name: NameFull: Li, Hui – PersonEntity: Name: NameFull: Buchweitz, Nathan – PersonEntity: Name: NameFull: Gordon, Daniel – PersonEntity: Name: NameFull: Wang, Shangping – PersonEntity: Name: NameFull: Daley, Dane – PersonEntity: Name: NameFull: Yao, Hai – PersonEntity: Name: NameFull: Wu, Yongren IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 53 – Type: issue Value: 6 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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