Effect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease.
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| Title: | Effect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease. |
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| Authors: | Chen, Yuxin1,2 (AUTHOR), Latisenko, Rudolfs3 (AUTHOR), Lynch, David A.4 (AUTHOR), Ciet, Pierluigi2,5 (AUTHOR), Charbonnier, Jean-Paul3 (AUTHOR), Tiddens, Harm A. W. M.1,2,3 (AUTHOR) h.tiddens@erasmusmc.nl |
| Source: | European Radiology. Jun2025, Vol. 35 Issue 6, p2990-2998. 9p. |
| Subjects: | Chronic obstructive pulmonary disease, Lung volume, Computed tomography, Bronchial arteries, Radiation exposure, Airway (Anatomy) |
| Abstract: | Background: The assessment of bronchus–artery (BA) metrics on chest CT is important for detecting airway abnormalities. It is less clear how BA metrics are dependent on lung volume. Methods: CTs were obtained from a COPDGene substudy investigating the impact of radiation dose on lung density. Patients with chronic obstructive pulmonary disease underwent a full-dose and a reduced-dose CT in the same imaging session. CTs were automatically analyzed by measuring diameters of the bronchial outer edge (Bout), bronchial inner wall (Bin), artery (A), and bronchial wall thickness (Bwt) from segmental (G0) and distal generations. BA ratios were computed: Bout/A, Bin/A, Bwt/A, and bronchial wall area/bronchial outer area (Bwa/Boa). The total lung volume of the CT (TLC-CT) was computed. Differences between the volumes between the two CTs were expressed as % of the highest TLC-CT (ΔTLC-CT%). For the BA metrics of each CT, we computed the median of measurements in G1–6. Mixed-effect models were used to investigate the influence of TLC-CT on BA metrics adjusted for dose protocol. Results: One thousand three hundred nineteen patients with a mean (SD) age of 64.4 (8.7) years were included. Three hundred twenty-nine (124) BA pairs were analyzed per CT. No significant difference was found for TLC-CT in relation to dose (p = 0.17). A ΔTLC-CT% of >10% (found in 121, 9%) led to 0.03 and 0.05 decreases in Bout/A and Bin/A and 0.008 and 0.11 decrease in log (Bwt/A) and log (Bwa/Boa), and a 0.03 increase in Bin and 0.06, 0.12, and 0.04 decrease in Bout, log (Bwt), and log (A) (all p < 0.001). Conclusions: Variations in TLC over 10% between time points significantly influence bronchial dimensions, affecting BA metrics. Standardizing volumes is recommended for sensitive tracking of airway disease changes over time. Key Points: QuestionAre BA metrics dependent on total lung capacity (TLC), and if so, how? FindingsTLC variations over 10% between time points significantly influence bronchial dimensions, affecting BA metrics. Variations below 10% between CT scans have little effect on BA metrics. Clinical relevanceSmall lung volume differences between chest CTs have little impact on bronchus and artery metrics; it is imperative to standardize chest CT lung volumes to ensure precise diagnosis and monitoring of airway disease. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 185184249 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen%2C+Yuxin%22">Chen, Yuxin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Latisenko%2C+Rudolfs%22">Latisenko, Rudolfs</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lynch%2C+David+A%2E%22">Lynch, David A.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ciet%2C+Pierluigi%22">Ciet, Pierluigi</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Charbonnier%2C+Jean-Paul%22">Charbonnier, Jean-Paul</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tiddens%2C+Harm+A%2E+W%2E+M%2E%22">Tiddens, Harm A. W. M.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> h.tiddens@erasmusmc.nl</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jun2025, Vol. 35 Issue 6, p2990-2998. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Chronic+obstructive+pulmonary+disease%22">Chronic obstructive pulmonary disease</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+volume%22">Lung volume</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Bronchial+arteries%22">Bronchial arteries</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation+exposure%22">Radiation exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Airway+%28Anatomy%29%22">Airway (Anatomy)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The assessment of bronchus–artery (BA) metrics on chest CT is important for detecting airway abnormalities. It is less clear how BA metrics are dependent on lung volume. Methods: CTs were obtained from a COPDGene substudy investigating the impact of radiation dose on lung density. Patients with chronic obstructive pulmonary disease underwent a full-dose and a reduced-dose CT in the same imaging session. CTs were automatically analyzed by measuring diameters of the bronchial outer edge (Bout), bronchial inner wall (Bin), artery (A), and bronchial wall thickness (Bwt) from segmental (G0) and distal generations. BA ratios were computed: Bout/A, Bin/A, Bwt/A, and bronchial wall area/bronchial outer area (Bwa/Boa). The total lung volume of the CT (TLC-CT) was computed. Differences between the volumes between the two CTs were expressed as % of the highest TLC-CT (ΔTLC-CT%). For the BA metrics of each CT, we computed the median of measurements in G1–6. Mixed-effect models were used to investigate the influence of TLC-CT on BA metrics adjusted for dose protocol. Results: One thousand three hundred nineteen patients with a mean (SD) age of 64.4 (8.7) years were included. Three hundred twenty-nine (124) BA pairs were analyzed per CT. No significant difference was found for TLC-CT in relation to dose (p = 0.17). A ΔTLC-CT% of >10% (found in 121, 9%) led to 0.03 and 0.05 decreases in Bout/A and Bin/A and 0.008 and 0.11 decrease in log (Bwt/A) and log (Bwa/Boa), and a 0.03 increase in Bin and 0.06, 0.12, and 0.04 decrease in Bout, log (Bwt), and log (A) (all p < 0.001). Conclusions: Variations in TLC over 10% between time points significantly influence bronchial dimensions, affecting BA metrics. Standardizing volumes is recommended for sensitive tracking of airway disease changes over time. Key Points: QuestionAre BA metrics dependent on total lung capacity (TLC), and if so, how? FindingsTLC variations over 10% between time points significantly influence bronchial dimensions, affecting BA metrics. Variations below 10% between CT scans have little effect on BA metrics. Clinical relevanceSmall lung volume differences between chest CTs have little impact on bronchus and artery metrics; it is imperative to standardize chest CT lung volumes to ensure precise diagnosis and monitoring of airway disease. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-024-11126-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 2990 Subjects: – SubjectFull: Chronic obstructive pulmonary disease Type: general – SubjectFull: Lung volume Type: general – SubjectFull: Computed tomography Type: general – SubjectFull: Bronchial arteries Type: general – SubjectFull: Radiation exposure Type: general – SubjectFull: Airway (Anatomy) Type: general Titles: – TitleFull: Effect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen, Yuxin – PersonEntity: Name: NameFull: Latisenko, Rudolfs – PersonEntity: Name: NameFull: Lynch, David A. – PersonEntity: Name: NameFull: Ciet, Pierluigi – PersonEntity: Name: NameFull: Charbonnier, Jean-Paul – PersonEntity: Name: NameFull: Tiddens, Harm A. W. M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 6 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
