Ultra-high-resolution 40 keV virtual monoenergetic imaging using spectral photon-counting CT in high-risk patients for coronary stenoses.
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| Title: | Ultra-high-resolution 40 keV virtual monoenergetic imaging using spectral photon-counting CT in high-risk patients for coronary stenoses. |
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| Authors: | Fahrni, Guillaume1,2,3 (AUTHOR), Boccalini, Sara2,3 (AUTHOR), Lacombe, Hugo2,4 (AUTHOR), de Oliveira, Fabien5 (AUTHOR), Houmeau, Angèle2 (AUTHOR), Francart, Florie5 (AUTHOR), Villien, Marjorie4 (AUTHOR), Rotzinger, David C.1 (AUTHOR), Robert, Antoine2 (AUTHOR), Douek, Philippe2,3 (AUTHOR), Si-Mohamed, Salim A.2,3 (AUTHOR) salim.si-mohamed@chu-lyon.fr |
| Source: | European Radiology. Jun2025, Vol. 35 Issue 6, p3042-3053. 12p. |
| Subjects: | Coronary artery stenosis, Coronary angiography, Dual energy CT (Tomography), Spectral imaging, Critically ill, Image quality analysis, High resolution imaging |
| Abstract: | Objectives: To assess the image quality of ultra-high-resolution (UHR) virtual monoenergetic images (VMIs) at 40 keV compared to 70 keV, using spectral photon-counting CT (SPCCT) and dual-layer dual-energy CT (DECT) for coronary computed tomography angiography (CCTA). Methods and materials: In this prospective IRB-approved study, 26 high-risk patients were included. CCTA was performed both with an SPCCT in UHR mode and with one of two DECT scanners (iQOn or CT7500) within 3 days. 40 keV and 70 keV VMIs were reconstructed for both modalities. Stenoses, blooming artefacts, and image quality were compared between all four reconstructions. Results: Twenty-six patients (4 women [15%]) and 28 coronary stenoses (mean stenosis of 56% ± 16%) were included. 40 keV SPCCT gave an overall higher quality score (5 [5, 5]) than 70 keV SPCCT (5 [4, 5], 40 keV DECT (4 [3, 4]) and 70 keV SPCCT (4 [4, 5]), p < 0.001). Less variability in stenosis measurement was found with SPCCT between 40 keV and 70 keV (bias: −1% ± 3%, LoA: 6%) compared with DECT (−6% ± 8%, LoA 16%). 40 keV SPCCT vs 40 keV DECT showed a −3% ± 6% bias, whereas 40 keV SPCCT vs 70 keV DECT showed a −8% ± 6% bias. From 70 keV to 40 keV, blooming artefacts did not increase with SPCCT (mean +2% ± 5%, p = 0.136) whereas they increased with DECT (mean +7% ± 6%, p = 0.005). Conclusion: UHR 40 keV SPCCT VMIs outperformed 40 keV and 70 keV DECT VMIs for assessing coronary artery stenoses, with no impairment compared to 70 keV SPCCT VMIs. Key Points: QuestionUse of low virtual mono-energetic images at 40 keV using spectral dual-energy and photon-counting CT systems is not yet established for diagnosing coronary artery stenosis. FindingsUHR 40 keV SPCCT enhances diagnostic accuracy in coronary artery assessment. Clinical relevanceBy combining spectral sensitivity with lower virtual mono-energetic imaging and ultra-high spatial resolution, SPCCT enhances coronary artery assessment, potentially leading to more accurate diagnoses and better patient outcomes in cardiovascular imaging. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 185184283 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ultra-high-resolution 40 keV virtual monoenergetic imaging using spectral photon-counting CT in high-risk patients for coronary stenoses. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fahrni%2C+Guillaume%22">Fahrni, Guillaume</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boccalini%2C+Sara%22">Boccalini, Sara</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lacombe%2C+Hugo%22">Lacombe, Hugo</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Oliveira%2C+Fabien%22">de Oliveira, Fabien</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Houmeau%2C+Angèle%22">Houmeau, Angèle</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Francart%2C+Florie%22">Francart, Florie</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Villien%2C+Marjorie%22">Villien, Marjorie</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rotzinger%2C+David+C%2E%22">Rotzinger, David C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robert%2C+Antoine%22">Robert, Antoine</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Douek%2C+Philippe%22">Douek, Philippe</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Si-Mohamed%2C+Salim+A%2E%22">Si-Mohamed, Salim A.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> salim.si-mohamed@chu-lyon.fr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jun2025, Vol. 35 Issue 6, p3042-3053. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Coronary+artery+stenosis%22">Coronary artery stenosis</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+angiography%22">Coronary angiography</searchLink><br /><searchLink fieldCode="DE" term="%22Dual+energy+CT+%28Tomography%29%22">Dual energy CT (Tomography)</searchLink><br /><searchLink fieldCode="DE" term="%22Spectral+imaging%22">Spectral imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Critically+ill%22">Critically ill</searchLink><br /><searchLink fieldCode="DE" term="%22Image+quality+analysis%22">Image quality analysis</searchLink><br /><searchLink fieldCode="DE" term="%22High+resolution+imaging%22">High resolution imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: To assess the image quality of ultra-high-resolution (UHR) virtual monoenergetic images (VMIs) at 40 keV compared to 70 keV, using spectral photon-counting CT (SPCCT) and dual-layer dual-energy CT (DECT) for coronary computed tomography angiography (CCTA). Methods and materials: In this prospective IRB-approved study, 26 high-risk patients were included. CCTA was performed both with an SPCCT in UHR mode and with one of two DECT scanners (iQOn or CT7500) within 3 days. 40 keV and 70 keV VMIs were reconstructed for both modalities. Stenoses, blooming artefacts, and image quality were compared between all four reconstructions. Results: Twenty-six patients (4 women [15%]) and 28 coronary stenoses (mean stenosis of 56% ± 16%) were included. 40 keV SPCCT gave an overall higher quality score (5 [5, 5]) than 70 keV SPCCT (5 [4, 5], 40 keV DECT (4 [3, 4]) and 70 keV SPCCT (4 [4, 5]), p < 0.001). Less variability in stenosis measurement was found with SPCCT between 40 keV and 70 keV (bias: −1% ± 3%, LoA: 6%) compared with DECT (−6% ± 8%, LoA 16%). 40 keV SPCCT vs 40 keV DECT showed a −3% ± 6% bias, whereas 40 keV SPCCT vs 70 keV DECT showed a −8% ± 6% bias. From 70 keV to 40 keV, blooming artefacts did not increase with SPCCT (mean +2% ± 5%, p = 0.136) whereas they increased with DECT (mean +7% ± 6%, p = 0.005). Conclusion: UHR 40 keV SPCCT VMIs outperformed 40 keV and 70 keV DECT VMIs for assessing coronary artery stenoses, with no impairment compared to 70 keV SPCCT VMIs. Key Points: QuestionUse of low virtual mono-energetic images at 40 keV using spectral dual-energy and photon-counting CT systems is not yet established for diagnosing coronary artery stenosis. FindingsUHR 40 keV SPCCT enhances diagnostic accuracy in coronary artery assessment. Clinical relevanceBy combining spectral sensitivity with lower virtual mono-energetic imaging and ultra-high spatial resolution, SPCCT enhances coronary artery assessment, potentially leading to more accurate diagnoses and better patient outcomes in cardiovascular imaging. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-024-11237-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 3042 Subjects: – SubjectFull: Coronary artery stenosis Type: general – SubjectFull: Coronary angiography Type: general – SubjectFull: Dual energy CT (Tomography) Type: general – SubjectFull: Spectral imaging Type: general – SubjectFull: Critically ill Type: general – SubjectFull: Image quality analysis Type: general – SubjectFull: High resolution imaging Type: general Titles: – TitleFull: Ultra-high-resolution 40 keV virtual monoenergetic imaging using spectral photon-counting CT in high-risk patients for coronary stenoses. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fahrni, Guillaume – PersonEntity: Name: NameFull: Boccalini, Sara – PersonEntity: Name: NameFull: Lacombe, Hugo – PersonEntity: Name: NameFull: de Oliveira, Fabien – PersonEntity: Name: NameFull: Houmeau, Angèle – PersonEntity: Name: NameFull: Francart, Florie – PersonEntity: Name: NameFull: Villien, Marjorie – PersonEntity: Name: NameFull: Rotzinger, David C. – PersonEntity: Name: NameFull: Robert, Antoine – PersonEntity: Name: NameFull: Douek, Philippe – PersonEntity: Name: NameFull: Si-Mohamed, Salim A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 6 Titles: – TitleFull: European Radiology Type: main |
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