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Comparison of abbreviated and complete MRI protocols for treatment response assessment of colorectal liver metastases.

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Title: Comparison of abbreviated and complete MRI protocols for treatment response assessment of colorectal liver metastases.
Authors: El Homsi, Maria1 (AUTHOR) mariaelhomsi@gmail.com, Bou Ayache, Jad1 (AUTHOR), Fernandes, Maria Clara1 (AUTHOR), Horvat, Natally1 (AUTHOR), Kim, Tae Hyung1 (AUTHOR), LaGratta, Maria1 (AUTHOR), Levin, Galina1 (AUTHOR), Rosen, Ally1 (AUTHOR), Gangai, Natalie1 (AUTHOR), Lobaugh, Stephanie2 (AUTHOR), Zheng, Junting2 (AUTHOR), Capanu, Marinela2 (AUTHOR), Do, Richard Kinh Gian1 (AUTHOR)
Source: European Radiology. Jun2025, Vol. 35 Issue 6, p3450-3459. 10p.
Subjects: Magnetic resonance imaging, Colorectal liver metastasis, Inter-observer reliability, Cost effectiveness, Treatment effectiveness, Cancer invasiveness
Abstract: Objective: To compare abbreviated magnetic resonance imaging (MRI) to complete MRI for treatment response assessment of colorectal liver metastases. Material and methods: This retrospective study included consecutive patients with colorectal liver metastases between January 1, 2012, and December 3, 2021, who were undergoing chemotherapy and who had at least one follow-up gadoxetic-enhanced MRI. For each patient, two MRIs (baseline MRI and follow-up MRI) were randomly selected. Follow-up MRIs were separated into two sets of images: complete MRIs, including all imaging sequences, and abbreviated MRIs, including coronal and axial hepatobiliary phase imaging, axial diffusion-weighted imaging, and coronal T2-weighted imaging. Seven radiologists reviewed the two sets of images, with a month's break in between, assessing Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 category and the presence of new lesions, with each reader assigned 80–91 patients. Inter-reader agreement was assessed using Fleiss' kappa (κ). Results: One-hundred ninety-five patients (mean age 54.4 +/− 12.1 years, 135 men) were evaluated. Intra-reader agreement between abbreviated and complete MRI was substantial for the RECIST 1.1 category (κ, 0.66–0.89) and the detection of new lesions (κ, 0.63–0.81). Inter-reader agreement was substantial for RECIST 1.1 category using abbreviated MRI and complete MRI (κ, 0.71 (95% CI: 0.65–0.78) and 0.68 (95% CI: 0.61–0.75)), and moderate for the presence of new lesions using abbreviated MRI and complete MRI (κ, 0.56 (95% CI: 0.41–0.69) and 0.49 (95% CI: 0.35–0.65)). Conclusion: Abbreviated MRI may serve as an alternative to complete MRI for the follow-up of patients with colorectal liver metastases. Key Points: QuestionAbbreviated MRI is a time-saving and cost-effective exam, but only one study has compared it with complete MRI for treatment response assessment of colorectal liver metastases. FindingsIn our study, abbreviated follow-up MRI achieved substantial inter-reader agreement for the RECIST 1.1 category and moderate inter-reader agreement for the presence of new lesions. Clinical relevanceAbbreviated liver MRIs are adequate substitutes for complete liver MRIs for colorectal liver metastases in the follow-up setting when the goal is to assess treatment response, resulting in shorter examination times and potential reductions in costs. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Comparison of abbreviated and complete MRI protocols for treatment response assessment of colorectal liver metastases.
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  Data: <searchLink fieldCode="AR" term="%22El+Homsi%2C+Maria%22">El Homsi, Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mariaelhomsi@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Bou+Ayache%2C+Jad%22">Bou Ayache, Jad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fernandes%2C+Maria+Clara%22">Fernandes, Maria Clara</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Horvat%2C+Natally%22">Horvat, Natally</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Tae+Hyung%22">Kim, Tae Hyung</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22LaGratta%2C+Maria%22">LaGratta, Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Levin%2C+Galina%22">Levin, Galina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rosen%2C+Ally%22">Rosen, Ally</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gangai%2C+Natalie%22">Gangai, Natalie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lobaugh%2C+Stephanie%22">Lobaugh, Stephanie</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Junting%22">Zheng, Junting</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Capanu%2C+Marinela%22">Capanu, Marinela</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Do%2C+Richard+Kinh+Gian%22">Do, Richard Kinh Gian</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jun2025, Vol. 35 Issue 6, p3450-3459. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Colorectal+liver+metastasis%22">Colorectal liver metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Inter-observer+reliability%22">Inter-observer reliability</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+effectiveness%22">Cost effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To compare abbreviated magnetic resonance imaging (MRI) to complete MRI for treatment response assessment of colorectal liver metastases. Material and methods: This retrospective study included consecutive patients with colorectal liver metastases between January 1, 2012, and December 3, 2021, who were undergoing chemotherapy and who had at least one follow-up gadoxetic-enhanced MRI. For each patient, two MRIs (baseline MRI and follow-up MRI) were randomly selected. Follow-up MRIs were separated into two sets of images: complete MRIs, including all imaging sequences, and abbreviated MRIs, including coronal and axial hepatobiliary phase imaging, axial diffusion-weighted imaging, and coronal T2-weighted imaging. Seven radiologists reviewed the two sets of images, with a month's break in between, assessing Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 category and the presence of new lesions, with each reader assigned 80–91 patients. Inter-reader agreement was assessed using Fleiss' kappa (κ). Results: One-hundred ninety-five patients (mean age 54.4 +/− 12.1 years, 135 men) were evaluated. Intra-reader agreement between abbreviated and complete MRI was substantial for the RECIST 1.1 category (κ, 0.66–0.89) and the detection of new lesions (κ, 0.63–0.81). Inter-reader agreement was substantial for RECIST 1.1 category using abbreviated MRI and complete MRI (κ, 0.71 (95% CI: 0.65–0.78) and 0.68 (95% CI: 0.61–0.75)), and moderate for the presence of new lesions using abbreviated MRI and complete MRI (κ, 0.56 (95% CI: 0.41–0.69) and 0.49 (95% CI: 0.35–0.65)). Conclusion: Abbreviated MRI may serve as an alternative to complete MRI for the follow-up of patients with colorectal liver metastases. Key Points: QuestionAbbreviated MRI is a time-saving and cost-effective exam, but only one study has compared it with complete MRI for treatment response assessment of colorectal liver metastases. FindingsIn our study, abbreviated follow-up MRI achieved substantial inter-reader agreement for the RECIST 1.1 category and moderate inter-reader agreement for the presence of new lesions. Clinical relevanceAbbreviated liver MRIs are adequate substitutes for complete liver MRIs for colorectal liver metastases in the follow-up setting when the goal is to assess treatment response, resulting in shorter examination times and potential reductions in costs. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-024-11277-3
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