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Polycrystalline boron nitride microflowers for non-invasive vitamin B3 (nicotinamide) sensing.

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Title: Polycrystalline boron nitride microflowers for non-invasive vitamin B3 (nicotinamide) sensing.
Authors: Farhan, Muhammad1 (AUTHOR), Subhan, Muhammad2 (AUTHOR), Naseem, Shahzad1 (AUTHOR), Riaz, Saira1 (AUTHOR), Awan, Rashid1 (AUTHOR), Mujahid, Adnan2 (AUTHOR), Afzal, Adeel1,2 (AUTHOR) adeel.chem@pu.edu.pk
Source: Diamond & Related Materials. May2025, Vol. 155, pN.PAG-N.PAG. 1p.
Subjects: Electrochemical sensors, Boron nitride, Parkinson's disease, Charge exchange, Charge transfer
Abstract: Accurate detection of nicotinamide (vitamin B3) is critical in biomedical diagnostics due to its essential role in cellular metabolism, DNA repair, and oxidative stress regulation. Abnormal nicotinamide levels are associated with metabolic disorders, neurodegenerative diseases, and conditions such as pellagra, Parkinson's disease, and diabetes, necessitating highly sensitive and selective detection methods. This study presents an advanced electrochemical sensor using self-organized polycrystalline boron nitride (BN) microflowers, synthesized via a solvothermal method, to achieve superior sensitivity and detection limits for nicotinamide sensing. BN microflowers exhibit a unique polycrystalline structure, excitation-dependent blue photoluminescence, a wide bandgap, and a hierarchical flower-like morphology, as confirmed by advanced analytical techniques. When integrated with graphitic electrodes, BN microflowers enhance electroactive surface area, reduce interfacial charge transfer resistance, and improve electron transfer kinetics, leading to exceptional electrochemical performance. The sensor demonstrates a high sensitivity of 2.42 ± 0.23 μA cm−2 nM−1, an ultralow detection limit of 330 pM, and a quantification limit of 1 nM. Additionally, the device exhibits excellent reproducibility, operational stability, and selectivity against salivary metabolites, including creatinine, uric acid, glutamine, tyrosine, and urea. This work represents the first application of BN microflowers for electrochemical nicotinamide detection, establishing a new benchmark for non-invasive vitamin B3 sensing with significant implications for biomedical diagnostics. [Display omitted] • Polycrystalline BN microflowers are synthesized via a solvothermal method. • BN microflowers enable ultrasensitive nicotinamide (Vitamin B3) detection. • A highly electroactive surface enhances charge transfer and sensor performance. • The electrochemical sensor achieves an ultra-low detection limit of 330 pM. • Demonstrates potential for non-invasive biomedical diagnostics and POCT [ABSTRACT FROM AUTHOR]
Copyright of Diamond & Related Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 185226894
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  Data: Polycrystalline boron nitride microflowers for non-invasive vitamin B3 (nicotinamide) sensing.
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  Data: <searchLink fieldCode="AR" term="%22Farhan%2C+Muhammad%22">Farhan, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Subhan%2C+Muhammad%22">Subhan, Muhammad</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Naseem%2C+Shahzad%22">Naseem, Shahzad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riaz%2C+Saira%22">Riaz, Saira</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Awan%2C+Rashid%22">Awan, Rashid</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mujahid%2C+Adnan%22">Mujahid, Adnan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Afzal%2C+Adeel%22">Afzal, Adeel</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> adeel.chem@pu.edu.pk</i>
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  Data: <searchLink fieldCode="JN" term="%22Diamond+%26+Related+Materials%22">Diamond & Related Materials</searchLink>. May2025, Vol. 155, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Electrochemical+sensors%22">Electrochemical sensors</searchLink><br /><searchLink fieldCode="DE" term="%22Boron+nitride%22">Boron nitride</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Charge+exchange%22">Charge exchange</searchLink><br /><searchLink fieldCode="DE" term="%22Charge+transfer%22">Charge transfer</searchLink>
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  Data: Accurate detection of nicotinamide (vitamin B3) is critical in biomedical diagnostics due to its essential role in cellular metabolism, DNA repair, and oxidative stress regulation. Abnormal nicotinamide levels are associated with metabolic disorders, neurodegenerative diseases, and conditions such as pellagra, Parkinson's disease, and diabetes, necessitating highly sensitive and selective detection methods. This study presents an advanced electrochemical sensor using self-organized polycrystalline boron nitride (BN) microflowers, synthesized via a solvothermal method, to achieve superior sensitivity and detection limits for nicotinamide sensing. BN microflowers exhibit a unique polycrystalline structure, excitation-dependent blue photoluminescence, a wide bandgap, and a hierarchical flower-like morphology, as confirmed by advanced analytical techniques. When integrated with graphitic electrodes, BN microflowers enhance electroactive surface area, reduce interfacial charge transfer resistance, and improve electron transfer kinetics, leading to exceptional electrochemical performance. The sensor demonstrates a high sensitivity of 2.42 ± 0.23 μA cm−2 nM−1, an ultralow detection limit of 330 pM, and a quantification limit of 1 nM. Additionally, the device exhibits excellent reproducibility, operational stability, and selectivity against salivary metabolites, including creatinine, uric acid, glutamine, tyrosine, and urea. This work represents the first application of BN microflowers for electrochemical nicotinamide detection, establishing a new benchmark for non-invasive vitamin B3 sensing with significant implications for biomedical diagnostics. [Display omitted] • Polycrystalline BN microflowers are synthesized via a solvothermal method. • BN microflowers enable ultrasensitive nicotinamide (Vitamin B3) detection. • A highly electroactive surface enhances charge transfer and sensor performance. • The electrochemical sensor achieves an ultra-low detection limit of 330 pM. • Demonstrates potential for non-invasive biomedical diagnostics and POCT [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Diamond & Related Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1016/j.diamond.2025.112296
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      – Code: eng
        Text: English
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      – SubjectFull: Electrochemical sensors
        Type: general
      – SubjectFull: Boron nitride
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Charge exchange
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      – SubjectFull: Charge transfer
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      – TitleFull: Polycrystalline boron nitride microflowers for non-invasive vitamin B3 (nicotinamide) sensing.
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            NameFull: Farhan, Muhammad
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            – D: 01
              M: 05
              Text: May2025
              Type: published
              Y: 2025
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              Value: 155
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