View in EDS HTML Full Text PDF Full Text

MOF-engineered Cu2O nanozymes with boosted peroxidase-like activity for colorimetric-fluorescent dual-mode detection of deoxynivalenol.

Saved in:
Bibliographic Details
Title: MOF-engineered Cu2O nanozymes with boosted peroxidase-like activity for colorimetric-fluorescent dual-mode detection of deoxynivalenol.
Authors: Zhu, Xiaodong1 (AUTHOR), He, Yangchun1 (AUTHOR), Xie, Xinhua1,2 (AUTHOR), Zhang, Bobo1,2 (AUTHOR), Wang, Junhao1 (AUTHOR), Shen, Haoran3 (AUTHOR), Liu, Yingju3 (AUTHOR), Ji, Huifu4 (AUTHOR) jihuifu@126.com, Zhu, Hongshuai1,2,3 (AUTHOR) zhuhongshuai2021@henau.edu.cn
Source: Microchimica Acta. May2025, Vol. 192 Issue 5, p1-14. 14p.
Subjects: Complex matrices, Drinking water, Charge transfer, Metal-organic frameworks, Synthetic enzymes
Abstract: The development of a high sensitivity biosensor for the detection of highly toxic deoxynivalenol (DON) is vital for human health and food security. In this work, by integrating metal-organic frameworks (MOF) with cubic Cu2O nanoparticles (Cu2O@MOF), the nanocomposite achieved a 4.8-fold increase in specific surface area compared to pristine Cu2O, which synergistically enhanced its peroxidase-like (POD) activity through optimized substrate affinity and accelerated charge transfer. Consequently, based on the marriage properties of POD activity and fluorescence signal from Cu2O@MOF nanoparticles and carbon dots (CDs), a colorimentric-fluorescent dual-mode biosensor was constructed for DON detection. Concurrently, the competitive binding of DON with immobilized antigens on Cu2O@MOF-CDs results in antibody displacement, leading to progressive reduction of captured probes with increasing DON concentrations, thereby inducing proportional attenuation in both colorimetric and fluorescence signal intensities. Under the optimum conditions, the established biosensor achieved a detection limit of 0.0018 ng/mL for DON. Furthermore, the prepared dual-mode biosensor was successfully applied to detect DON in tap water, wheat and corn, demonstrating its practical utility for real-world applications. Overall, this work not only advances nanozyme design through MOF-mediated interface engineering but also provides a rapid, accurate, and field-deployable strategy for monitoring mycotoxins in complex matrices. [ABSTRACT FROM AUTHOR]
Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 185240436
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: MOF-engineered Cu<subscript>2</subscript>O nanozymes with boosted peroxidase-like activity for colorimetric-fluorescent dual-mode detection of deoxynivalenol.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhu%2C+Xiaodong%22">Zhu, Xiaodong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Yangchun%22">He, Yangchun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Xinhua%22">Xie, Xinhua</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bobo%22">Zhang, Bobo</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Junhao%22">Wang, Junhao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Haoran%22">Shen, Haoran</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yingju%22">Liu, Yingju</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ji%2C+Huifu%22">Ji, Huifu</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> jihuifu@126.com</i><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Hongshuai%22">Zhu, Hongshuai</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> zhuhongshuai2021@henau.edu.cn</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Microchimica+Acta%22">Microchimica Acta</searchLink>. May2025, Vol. 192 Issue 5, p1-14. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Complex+matrices%22">Complex matrices</searchLink><br /><searchLink fieldCode="DE" term="%22Drinking+water%22">Drinking water</searchLink><br /><searchLink fieldCode="DE" term="%22Charge+transfer%22">Charge transfer</searchLink><br /><searchLink fieldCode="DE" term="%22Metal-organic+frameworks%22">Metal-organic frameworks</searchLink><br /><searchLink fieldCode="DE" term="%22Synthetic+enzymes%22">Synthetic enzymes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The development of a high sensitivity biosensor for the detection of highly toxic deoxynivalenol (DON) is vital for human health and food security. In this work, by integrating metal-organic frameworks (MOF) with cubic Cu2O nanoparticles (Cu2O@MOF), the nanocomposite achieved a 4.8-fold increase in specific surface area compared to pristine Cu2O, which synergistically enhanced its peroxidase-like (POD) activity through optimized substrate affinity and accelerated charge transfer. Consequently, based on the marriage properties of POD activity and fluorescence signal from Cu2O@MOF nanoparticles and carbon dots (CDs), a colorimentric-fluorescent dual-mode biosensor was constructed for DON detection. Concurrently, the competitive binding of DON with immobilized antigens on Cu2O@MOF-CDs results in antibody displacement, leading to progressive reduction of captured probes with increasing DON concentrations, thereby inducing proportional attenuation in both colorimetric and fluorescence signal intensities. Under the optimum conditions, the established biosensor achieved a detection limit of 0.0018 ng/mL for DON. Furthermore, the prepared dual-mode biosensor was successfully applied to detect DON in tap water, wheat and corn, demonstrating its practical utility for real-world applications. Overall, this work not only advances nanozyme design through MOF-mediated interface engineering but also provides a rapid, accurate, and field-deployable strategy for monitoring mycotoxins in complex matrices. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=185240436
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00604-025-07140-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: Complex matrices
        Type: general
      – SubjectFull: Drinking water
        Type: general
      – SubjectFull: Charge transfer
        Type: general
      – SubjectFull: Metal-organic frameworks
        Type: general
      – SubjectFull: Synthetic enzymes
        Type: general
    Titles:
      – TitleFull: MOF-engineered Cu2O nanozymes with boosted peroxidase-like activity for colorimetric-fluorescent dual-mode detection of deoxynivalenol.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhu, Xiaodong
      – PersonEntity:
          Name:
            NameFull: He, Yangchun
      – PersonEntity:
          Name:
            NameFull: Xie, Xinhua
      – PersonEntity:
          Name:
            NameFull: Zhang, Bobo
      – PersonEntity:
          Name:
            NameFull: Wang, Junhao
      – PersonEntity:
          Name:
            NameFull: Shen, Haoran
      – PersonEntity:
          Name:
            NameFull: Liu, Yingju
      – PersonEntity:
          Name:
            NameFull: Ji, Huifu
      – PersonEntity:
          Name:
            NameFull: Zhu, Hongshuai
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 00263672
          Numbering:
            – Type: volume
              Value: 192
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Microchimica Acta
              Type: main
ResultId 1