Exploring the Role of Nutraceuticals in the Management and Prevention of Experimental‐Induced Abdominal Aortic Aneurysms: Mechanisms and Therapeutic Potential.

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Title: Exploring the Role of Nutraceuticals in the Management and Prevention of Experimental‐Induced Abdominal Aortic Aneurysms: Mechanisms and Therapeutic Potential.
Authors: Yang, Yi1 (AUTHOR), Chen, Kun2 (AUTHOR), Chen, Jun1 (AUTHOR) 13013919288@163.com, Sabihi, Sima-Sadat3 (AUTHOR) simasadatsabihi1365@outlook.com, Afifi, Mohamed (AUTHOR)
Source: Journal of Food Biochemistry. 5/25/2025, Vol. 2025, p1-11. 11p.
Subjects: Abdominal aortic aneurysms, Thoracic aneurysms, Heart cells, Muscle cells, Smooth muscle
Abstract: A potentially fatal ailment, abdominal aortic aneurysms (AAAs) frequently result in death by dissection or rupture. AAA is caused by a histopathologic anomaly that includes smooth muscle cell loss, media degeneration, inflammatory cell infiltration, and elastic fiber damage in the aorta wall. Nevertheless, it is still unknown how AAAs form. Improved knowledge of how AAA develops and progresses might lead to the development of innovative, less intrusive treatment approaches for those suffering from this debilitating illness. Functional foods have a range of protective impacts, such as antioxidant, anti‐inflammatory, antifibrotic, anticarcinogenic, and cardiovascular protective impacts, as shown by numerous human and animal research. Pretreatment with nutraceuticals can suppress the growth of AAA and pro‐inflammatory markers. The use of nutraceuticals to treat ischemic‐reperfusion cardiac cells has been shown to protect against ischemia–reperfusion damage through a diversity of mechanisms. This information was most recently reported. Thus, by inhibiting apoptosis, oxidative damage, c‐Jun N‐terminal kinase pathway, and inflammation, we investigated the impact of nutraceuticals on experimental‐induced AAA in the current review. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Exploring the Role of Nutraceuticals in the Management and Prevention of Experimental‐Induced Abdominal Aortic Aneurysms: Mechanisms and Therapeutic Potential.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Yi%22">Yang, Yi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Kun%22">Chen, Kun</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Jun%22">Chen, Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> 13013919288@163.com</i><br /><searchLink fieldCode="AR" term="%22Sabihi%2C+Sima-Sadat%22">Sabihi, Sima-Sadat</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> simasadatsabihi1365@outlook.com</i><br /><searchLink fieldCode="AR" term="%22Afifi%2C+Mohamed%22">Afifi, Mohamed</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 5/25/2025, Vol. 2025, p1-11. 11p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Abdominal+aortic+aneurysms%22">Abdominal aortic aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Thoracic+aneurysms%22">Thoracic aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+cells%22">Heart cells</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+cells%22">Muscle cells</searchLink><br /><searchLink fieldCode="DE" term="%22Smooth+muscle%22">Smooth muscle</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A potentially fatal ailment, abdominal aortic aneurysms (AAAs) frequently result in death by dissection or rupture. AAA is caused by a histopathologic anomaly that includes smooth muscle cell loss, media degeneration, inflammatory cell infiltration, and elastic fiber damage in the aorta wall. Nevertheless, it is still unknown how AAAs form. Improved knowledge of how AAA develops and progresses might lead to the development of innovative, less intrusive treatment approaches for those suffering from this debilitating illness. Functional foods have a range of protective impacts, such as antioxidant, anti‐inflammatory, antifibrotic, anticarcinogenic, and cardiovascular protective impacts, as shown by numerous human and animal research. Pretreatment with nutraceuticals can suppress the growth of AAA and pro‐inflammatory markers. The use of nutraceuticals to treat ischemic‐reperfusion cardiac cells has been shown to protect against ischemia–reperfusion damage through a diversity of mechanisms. This information was most recently reported. Thus, by inhibiting apoptosis, oxidative damage, c‐Jun N‐terminal kinase pathway, and inflammation, we investigated the impact of nutraceuticals on experimental‐induced AAA in the current review. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1155/jfbc/3780766
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      – Code: eng
        Text: English
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        PageCount: 11
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    Subjects:
      – SubjectFull: Abdominal aortic aneurysms
        Type: general
      – SubjectFull: Thoracic aneurysms
        Type: general
      – SubjectFull: Heart cells
        Type: general
      – SubjectFull: Muscle cells
        Type: general
      – SubjectFull: Smooth muscle
        Type: general
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      – TitleFull: Exploring the Role of Nutraceuticals in the Management and Prevention of Experimental‐Induced Abdominal Aortic Aneurysms: Mechanisms and Therapeutic Potential.
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            NameFull: Yang, Yi
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            NameFull: Chen, Kun
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            NameFull: Sabihi, Sima-Sadat
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              M: 05
              Text: 5/25/2025
              Type: published
              Y: 2025
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