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Purification of lactide by deep eutectic solvent assisted phase-change extraction technology.

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Title: Purification of lactide by deep eutectic solvent assisted phase-change extraction technology.
Authors: Yu, Jiaming1,2,3 (AUTHOR), Xia, Xuanfeng3 (AUTHOR), Lei, Chuang1 (AUTHOR), Zhu, Jianluo1,3 (AUTHOR) hnlyzjl0379@163.com, Yu, Yanling1,2 (AUTHOR) yuyanling@hit.edu.cn
Source: Separation & Purification Technology. Nov2025, Vol. 372, pN.PAG-N.PAG. 1p.
Subjects: Phase transitions, Carbon emissions, Molecular clusters, Lactic acid, Amides, Choline chloride
Abstract: Impurities such as lactic acid and its oligomers in crude lactide (LT) significantly impair the quality of polylactide products. This study introduces a novel deep eutectic solvent assisted phase-change extraction (DES-PCE) method for efficient LT purification. By forming deep eutectic solvents (DESs) through the interaction of amides and acids, this method enables the separation of acid impurities during a temperature-driven phase transition, where LT crystallizes and impurities remain in the liquid phase. Centrifugation of the mixture yields high-purity LT, with N,N -Dimethylformamide (DMF) identified as the optimal amide, enhancing LT purity from 83.82% to 99.91% while achieving a yield of 95.97%. Mechanistic studies using FT-IR, NMR, and quantum chemical calculations elucidate the formation and function of DESs, as well as their impact on solubility and viscosity. Compared to conventional distillation, the DES-PCE process significantly reduces energy consumption and carbon dioxide emissions by 91% and 94%, respectively, showcasing its potential as a sustainable and cost-effective solution for LT purification. [ABSTRACT FROM AUTHOR]
Copyright of Separation & Purification Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 185597337
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Purification of lactide by deep eutectic solvent assisted phase-change extraction technology.
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  Data: <searchLink fieldCode="JN" term="%22Separation+%26+Purification+Technology%22">Separation & Purification Technology</searchLink>. Nov2025, Vol. 372, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Phase+transitions%22">Phase transitions</searchLink><br /><searchLink fieldCode="DE" term="%22Carbon+emissions%22">Carbon emissions</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+clusters%22">Molecular clusters</searchLink><br /><searchLink fieldCode="DE" term="%22Lactic+acid%22">Lactic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Amides%22">Amides</searchLink><br /><searchLink fieldCode="DE" term="%22Choline+chloride%22">Choline chloride</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Impurities such as lactic acid and its oligomers in crude lactide (LT) significantly impair the quality of polylactide products. This study introduces a novel deep eutectic solvent assisted phase-change extraction (DES-PCE) method for efficient LT purification. By forming deep eutectic solvents (DESs) through the interaction of amides and acids, this method enables the separation of acid impurities during a temperature-driven phase transition, where LT crystallizes and impurities remain in the liquid phase. Centrifugation of the mixture yields high-purity LT, with N,N -Dimethylformamide (DMF) identified as the optimal amide, enhancing LT purity from 83.82% to 99.91% while achieving a yield of 95.97%. Mechanistic studies using FT-IR, NMR, and quantum chemical calculations elucidate the formation and function of DESs, as well as their impact on solubility and viscosity. Compared to conventional distillation, the DES-PCE process significantly reduces energy consumption and carbon dioxide emissions by 91% and 94%, respectively, showcasing its potential as a sustainable and cost-effective solution for LT purification. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Separation & Purification Technology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.seppur.2025.133421
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Phase transitions
        Type: general
      – SubjectFull: Carbon emissions
        Type: general
      – SubjectFull: Molecular clusters
        Type: general
      – SubjectFull: Lactic acid
        Type: general
      – SubjectFull: Amides
        Type: general
      – SubjectFull: Choline chloride
        Type: general
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      – TitleFull: Purification of lactide by deep eutectic solvent assisted phase-change extraction technology.
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            NameFull: Yu, Jiaming
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            NameFull: Xia, Xuanfeng
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            NameFull: Lei, Chuang
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            – D: 01
              M: 11
              Text: Nov2025
              Type: published
              Y: 2025
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