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In-vitro evaluation of a multimodal pH-activatable nanoprobe for synergistic dual-drug delivery in tumor-targeted therapy.

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Title: In-vitro evaluation of a multimodal pH-activatable nanoprobe for synergistic dual-drug delivery in tumor-targeted therapy.
Authors: Farooq, Muhammad Umar1,2 (AUTHOR) umar@sjtu.edu.cn, Zairov, Rustem R.2,3 (AUTHOR)
Source: Materials Chemistry & Physics. Oct2025, Vol. 343, pN.PAG-N.PAG. 1p.
Subjects: Targeted drug delivery, Drug delivery systems, Controlled release drugs, Zinc ions, Gold nanoparticles
Abstract: A smart drug delivery system (DDs) based on PEGylated (polyethylene glycol) gold/zinc oxide (PEG-Au/ZnO) loaded with doxorubicin (DOX) and chlorine-e6 (Ce6) was successfully synthesized, characterized, and evaluated against breast malignancy. With and without laser exposure, the DOX-PEG-Au/ZnO–Ce6 nanoprobe bypassed the internal barriers and exhibited much higher synergistic therapeutic activity than Ce6 and DOX alone. The controlled release kinetics of DOX in combination with Ce6 could inhibit tumor growth and remarkably enhance the sensitivity of chemotherapy. Apart from the chemotherapeutic effect, the residual PEG-Au/ZnO could amplify the reactive oxygen species (ROS) generation through cascade reactions, which will benefit the release of free zinc ions in the lysosome of inflammatory cells. Taken together, the as-prepared DOX-PEG-Au/ZnO–Ce6 nanoprobe is expected to facilitate the management of chemo-photodynamic combination therapy as Trojan horses to eliminate cancer and improve the quality of life for the patient by reducing acute toxic side effects. [Display omitted] • A multifunctional pH-responsive PEG-Au/ZnO-based nanoprobe co-loaded with DOX and Ce6 was developed for enhanced chemo-PDT against breast cancer model. • The nanoprobe demonstrated controlled drug release, improved tumor penetration, and superior synergistic therapeutic efficacy with and without laser irradiation. • Residual PEG-Au/ZnO amplified ROS generation and lysosomal zinc ion release, contributing to enhanced cancer cell elimination with reduced systemic toxicity. [ABSTRACT FROM AUTHOR]
Copyright of Materials Chemistry & Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 185624915
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: In-vitro evaluation of a multimodal pH-activatable nanoprobe for synergistic dual-drug delivery in tumor-targeted therapy.
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  Data: <searchLink fieldCode="AR" term="%22Farooq%2C+Muhammad+Umar%22">Farooq, Muhammad Umar</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> umar@sjtu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zairov%2C+Rustem+R%2E%22">Zairov, Rustem R.</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Materials+Chemistry+%26+Physics%22">Materials Chemistry & Physics</searchLink>. Oct2025, Vol. 343, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Zinc+ions%22">Zinc ions</searchLink><br /><searchLink fieldCode="DE" term="%22Gold+nanoparticles%22">Gold nanoparticles</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A smart drug delivery system (DDs) based on PEGylated (polyethylene glycol) gold/zinc oxide (PEG-Au/ZnO) loaded with doxorubicin (DOX) and chlorine-e6 (Ce6) was successfully synthesized, characterized, and evaluated against breast malignancy. With and without laser exposure, the DOX-PEG-Au/ZnO–Ce6 nanoprobe bypassed the internal barriers and exhibited much higher synergistic therapeutic activity than Ce6 and DOX alone. The controlled release kinetics of DOX in combination with Ce6 could inhibit tumor growth and remarkably enhance the sensitivity of chemotherapy. Apart from the chemotherapeutic effect, the residual PEG-Au/ZnO could amplify the reactive oxygen species (ROS) generation through cascade reactions, which will benefit the release of free zinc ions in the lysosome of inflammatory cells. Taken together, the as-prepared DOX-PEG-Au/ZnO–Ce6 nanoprobe is expected to facilitate the management of chemo-photodynamic combination therapy as Trojan horses to eliminate cancer and improve the quality of life for the patient by reducing acute toxic side effects. [Display omitted] • A multifunctional pH-responsive PEG-Au/ZnO-based nanoprobe co-loaded with DOX and Ce6 was developed for enhanced chemo-PDT against breast cancer model. • The nanoprobe demonstrated controlled drug release, improved tumor penetration, and superior synergistic therapeutic efficacy with and without laser irradiation. • Residual PEG-Au/ZnO amplified ROS generation and lysosomal zinc ion release, contributing to enhanced cancer cell elimination with reduced systemic toxicity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials Chemistry & Physics is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.matchemphys.2025.131098
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
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      – SubjectFull: Targeted drug delivery
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Controlled release drugs
        Type: general
      – SubjectFull: Zinc ions
        Type: general
      – SubjectFull: Gold nanoparticles
        Type: general
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      – TitleFull: In-vitro evaluation of a multimodal pH-activatable nanoprobe for synergistic dual-drug delivery in tumor-targeted therapy.
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            NameFull: Farooq, Muhammad Umar
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            NameFull: Zairov, Rustem R.
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            – D: 01
              M: 10
              Text: Oct2025
              Type: published
              Y: 2025
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              Value: 343
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            – TitleFull: Materials Chemistry & Physics
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