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Recent advancements in paper microfluidics for blood analysis and diagnostics.

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Title: Recent advancements in paper microfluidics for blood analysis and diagnostics.
Authors: Yang, Zhiyuan1 (AUTHOR), Lou, Yafei1,2 (AUTHOR), Sun, Linan1,2 (AUTHOR), Chen, Siyu2 (AUTHOR), Li, Miaosi1,3 (AUTHOR) mli@universalbiosensors.com, Lu, Zhuoxuan4 (AUTHOR), Zhang, Liming1 (AUTHOR), Cao, Rong1 (AUTHOR) caorong_chem@163.com, Tian, Junfei1,2 (AUTHOR) jftian_scut@163.com
Source: Trends in Analytical Chemistry: TRAC. Sep2025, Vol. 190, pN.PAG-N.PAG. 1p.
Subjects: Blood grouping & crossmatching, Resource-limited settings, Blood testing, Blood sampling, Point-of-care testing, Microfluidics
Abstract: Paper microfluidics has emerged as a transformative technology in blood analysis and diagnostics, offering a portable, cost-effective, and user-friendly alternative to traditional laboratory tests. This review discusses the progress in paper microfluidics for blood tests over the past five years, focusing on their potential to revolutionize point-of-care testing in resource-limited settings. After providing an overview of blood composition and the evolution of blood testing technologies, the review explores innovative advances in emerging microfluidic paper-based analytical devices for blood detection. It categorizes their applications based on the type of blood sample used and whether pretreatment techniques are required, enabling developers to efficiently identify suitable methodologies aligned with the intended sample state and accelerate the prototyping of devices. In addition, this review summarizes how paper substrate, is innovatively repurposed into auxiliary tools to enhance blood detection processes through its adaptability. Challenges in commercialization and promising directions for future development are also discussed. [Display omitted] • An in-depth review of recent innovations in paper microfluidics for blood tests. • Applications are classified based on blood sample type and pretreatment method. • Novel repurposing of paper substrate as auxiliary tools in blood tests is reviewed. • Challenges and perspectives for paper-based blood tests are discussed. [ABSTRACT FROM AUTHOR]
Copyright of Trends in Analytical Chemistry: TRAC is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 185650833
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Recent advancements in paper microfluidics for blood analysis and diagnostics.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Zhiyuan%22">Yang, Zhiyuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lou%2C+Yafei%22">Lou, Yafei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Linan%22">Sun, Linan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Siyu%22">Chen, Siyu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Miaosi%22">Li, Miaosi</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> mli@universalbiosensors.com</i><br /><searchLink fieldCode="AR" term="%22Lu%2C+Zhuoxuan%22">Lu, Zhuoxuan</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Liming%22">Zhang, Liming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Rong%22">Cao, Rong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> caorong_chem@163.com</i><br /><searchLink fieldCode="AR" term="%22Tian%2C+Junfei%22">Tian, Junfei</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> jftian_scut@163.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Trends+in+Analytical+Chemistry%3A+TRAC%22">Trends in Analytical Chemistry: TRAC</searchLink>. Sep2025, Vol. 190, pN.PAG-N.PAG. 1p.
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  Data: Paper microfluidics has emerged as a transformative technology in blood analysis and diagnostics, offering a portable, cost-effective, and user-friendly alternative to traditional laboratory tests. This review discusses the progress in paper microfluidics for blood tests over the past five years, focusing on their potential to revolutionize point-of-care testing in resource-limited settings. After providing an overview of blood composition and the evolution of blood testing technologies, the review explores innovative advances in emerging microfluidic paper-based analytical devices for blood detection. It categorizes their applications based on the type of blood sample used and whether pretreatment techniques are required, enabling developers to efficiently identify suitable methodologies aligned with the intended sample state and accelerate the prototyping of devices. In addition, this review summarizes how paper substrate, is innovatively repurposed into auxiliary tools to enhance blood detection processes through its adaptability. Challenges in commercialization and promising directions for future development are also discussed. [Display omitted] • An in-depth review of recent innovations in paper microfluidics for blood tests. • Applications are classified based on blood sample type and pretreatment method. • Novel repurposing of paper substrate as auxiliary tools in blood tests is reviewed. • Challenges and perspectives for paper-based blood tests are discussed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Trends in Analytical Chemistry: TRAC is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=185650833
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.trac.2025.118289
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      – Code: eng
        Text: English
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        PageCount: 1
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    Subjects:
      – SubjectFull: Blood grouping & crossmatching
        Type: general
      – SubjectFull: Resource-limited settings
        Type: general
      – SubjectFull: Blood testing
        Type: general
      – SubjectFull: Blood sampling
        Type: general
      – SubjectFull: Point-of-care testing
        Type: general
      – SubjectFull: Microfluidics
        Type: general
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      – TitleFull: Recent advancements in paper microfluidics for blood analysis and diagnostics.
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            NameFull: Yang, Zhiyuan
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            NameFull: Lou, Yafei
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            NameFull: Sun, Linan
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            NameFull: Li, Miaosi
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            NameFull: Lu, Zhuoxuan
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          Dates:
            – D: 01
              M: 09
              Text: Sep2025
              Type: published
              Y: 2025
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