High‐resolution, volumetric diffusion‐weighted MR spectroscopic imaging of the brain.
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| Title: | High‐resolution, volumetric diffusion‐weighted MR spectroscopic imaging of the brain. |
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| Authors: | Wang, Zepeng1,2 (AUTHOR), Sutton, Bradley P.1,2,3 (AUTHOR), Lam, Fan1,2,3 (AUTHOR) fanlam1@illinois.edu |
| Source: | Magnetic Resonance in Medicine. Aug2025, Vol. 94 Issue 2, p450-469. 20p. |
| Subjects: | Spectroscopic imaging, Magnetic resonance imaging, Gray matter (Nerve tissue), White matter (Nerve tissue), Diffusion coefficients |
| Abstract: | Purpose: To achieve high‐resolution, three‐dimensional (3D) quantitative diffusion‐weighted MR spectroscopic imaging (DW‐MRSI) for molecule‐specific microstructural imaging of the brain. Methods: We introduced and integrated several innovative acquisition and processing strategies for DW‐MRSI: (a) a new double‐spin‐echo sequence combining selective excitation, bipolar diffusion encoding, rapid spatiospectral sampling, interleaved water spectroscopic imaging data, and a special sparsely sampled echo‐volume‐imaging (EVI)‐based navigator, (b) a rank‐constrained time‐resolved reconstruction from the EVI data to capture spatially varying phases, (c) a model‐based phase correction for DW‐MRSI data, and (d) a multi‐b‐value subspace‐based method for water/lipids removal and spatiospectral reconstruction using learned metabolite subspaces, and e) a hybrid subspace and parametric model‐based parameter estimation strategy. Phantom and in vivo experiments were performed to validate the proposed method and demonstrate its ability to map metabolite‐specific diffusion parameters in 3D. Results: The proposed method generated reproducible metabolite diffusion coefficient estimates, consistent with those from a standard single‐voxel DW spectroscopy (SV‐DWS) method. High‐SNR multi‐molecular mean diffusivity (MD) maps can be obtained at a 6.9 ×$$ \times $$ 6.9 ×$$ \times $$ 7.0 mm 3$$ {}^3 $$ nominal resolution with large 3D brain coverage. High‐resolution (4.4 ×$$ \times $$ 4.4 ×$$ \times $$ 5.6 mm 3$$ {}^3 $$) metabolite and diffusion coefficient maps can be obtained within 20 mins for the first time. Tissue‐dependent metabolite MDs were observed, i.e., larger MDs for NAA, creatine, and choline in white matter than gray matter, with region‐specific differences. Conclusion: We demonstrated an unprecedented capability of simultaneous, high‐resolution metabolite and diffusion parameter mapping. This imaging capability has strong potential to offer richer molecular and tissue‐compartment‐specific microstructural information for various clinical and neuroscience applications. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 185726142 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: High‐resolution, volumetric diffusion‐weighted MR spectroscopic imaging of the brain. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Zepeng%22">Wang, Zepeng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sutton%2C+Bradley+P%2E%22">Sutton, Bradley P.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lam%2C+Fan%22">Lam, Fan</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> fanlam1@illinois.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Aug2025, Vol. 94 Issue 2, p450-469. 20p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Spectroscopic+imaging%22">Spectroscopic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Gray+matter+%28Nerve+tissue%29%22">Gray matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+coefficients%22">Diffusion coefficients</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To achieve high‐resolution, three‐dimensional (3D) quantitative diffusion‐weighted MR spectroscopic imaging (DW‐MRSI) for molecule‐specific microstructural imaging of the brain. Methods: We introduced and integrated several innovative acquisition and processing strategies for DW‐MRSI: (a) a new double‐spin‐echo sequence combining selective excitation, bipolar diffusion encoding, rapid spatiospectral sampling, interleaved water spectroscopic imaging data, and a special sparsely sampled echo‐volume‐imaging (EVI)‐based navigator, (b) a rank‐constrained time‐resolved reconstruction from the EVI data to capture spatially varying phases, (c) a model‐based phase correction for DW‐MRSI data, and (d) a multi‐b‐value subspace‐based method for water/lipids removal and spatiospectral reconstruction using learned metabolite subspaces, and e) a hybrid subspace and parametric model‐based parameter estimation strategy. Phantom and in vivo experiments were performed to validate the proposed method and demonstrate its ability to map metabolite‐specific diffusion parameters in 3D. Results: The proposed method generated reproducible metabolite diffusion coefficient estimates, consistent with those from a standard single‐voxel DW spectroscopy (SV‐DWS) method. High‐SNR multi‐molecular mean diffusivity (MD) maps can be obtained at a 6.9 ×$$ \times $$ 6.9 ×$$ \times $$ 7.0 mm 3$$ {}^3 $$ nominal resolution with large 3D brain coverage. High‐resolution (4.4 ×$$ \times $$ 4.4 ×$$ \times $$ 5.6 mm 3$$ {}^3 $$) metabolite and diffusion coefficient maps can be obtained within 20 mins for the first time. Tissue‐dependent metabolite MDs were observed, i.e., larger MDs for NAA, creatine, and choline in white matter than gray matter, with region‐specific differences. Conclusion: We demonstrated an unprecedented capability of simultaneous, high‐resolution metabolite and diffusion parameter mapping. This imaging capability has strong potential to offer richer molecular and tissue‐compartment‐specific microstructural information for various clinical and neuroscience applications. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30479 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 450 Subjects: – SubjectFull: Spectroscopic imaging Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Gray matter (Nerve tissue) Type: general – SubjectFull: White matter (Nerve tissue) Type: general – SubjectFull: Diffusion coefficients Type: general Titles: – TitleFull: High‐resolution, volumetric diffusion‐weighted MR spectroscopic imaging of the brain. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Zepeng – PersonEntity: Name: NameFull: Sutton, Bradley P. – PersonEntity: Name: NameFull: Lam, Fan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 94 – Type: issue Value: 2 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
