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Regionally resolved cardiac metabolism using a dipole‐loop array coil for 7 T 31P‐MRSI.

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Title: Regionally resolved cardiac metabolism using a dipole‐loop array coil for 7 T 31P‐MRSI.
Authors: Karkouri, Jabrane1 (AUTHOR) jk793@cam.ac.uk, Watson, Will2 (AUTHOR), Forner, Ria3 (AUTHOR), Weir‐McCall, Jonathan R.4,5 (AUTHOR), Horn, Tracy1 (AUTHOR), Hill, Marion1 (AUTHOR), Hoole, Stephen4,6 (AUTHOR), Klomp, Dennis3 (AUTHOR), Rodgers, Christopher T.1 (AUTHOR)
Source: Magnetic Resonance in Medicine. Aug2025, Vol. 94 Issue 2, p480-496. 17p.
Subjects: Heart metabolism, Spectroscopic imaging, Magnetic resonance imaging, Heart failure, Volunteers
Abstract: Purpose: We introduce a novel commercial phosphorus‐31 (31P) dipole‐loop array coil, describing the coil hardware and testing its performance on phantoms. We used this coil to assess cardiac metabolism per region in healthy volunteers. Methods: B1+ field maps were simulated and compared to maps measured with a set of CSI sequences with varying voltages. Seventeen volunteers were scanned with 7 T phosphorus‐31 magnetic resonance spectroscopic imaging (31P‐MRSI). Reproducibility was assessed in nine of these volunteers. Strain was measured for six of these volunteers at 3 T. Results: Blood‐ and saturation‐corrected Phosphocreatine/γ‐adenosine triphosphate (PCr/ATP) ratios were measured for four regions of the left ventricle: 1.86 in septum, 2.25 in anterior wall, 1.41 in inferior wall, and 1.53 in lateral wall, respectively. These are in the expected range compared to previous studies. B1+ maps show good signal uniformity around the position of the heart (0.13 ± 0.06 μT/sqrt(W)). Intrasession and intersession coefficients of reproducibility were 0.22–0.88 and 0.29–0.79, respectively. Linear modeling shows that regional PCr/γATP correlates with circumferential strain but not radial strain. This requires corroboration by a larger study including patients with impaired function and energetics. Conclusion: Dipole‐loop array coils present a promising new approach for human cardiac 31P‐MRSI at 7 T. Their favorable B1+ uniformity at depth and specific absorption rate over loop arrays and improved SNR when combined with loops for reception could be beneficial for further clinical studies measuring energetics by 31P‐MRSI at 7 T. The new capability to assess PCr/γATP ratios across the whole left ventricle could enable clinical studies to investigate regional changes in cardiac energetics for the first time. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Regionally resolved cardiac metabolism using a dipole‐loop array coil for 7 T <superscript>31</superscript>P‐MRSI.
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Aug2025, Vol. 94 Issue 2, p480-496. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Heart+metabolism%22">Heart metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Spectroscopic+imaging%22">Spectroscopic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+failure%22">Heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22Volunteers%22">Volunteers</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: We introduce a novel commercial phosphorus‐31 (31P) dipole‐loop array coil, describing the coil hardware and testing its performance on phantoms. We used this coil to assess cardiac metabolism per region in healthy volunteers. Methods: B1+ field maps were simulated and compared to maps measured with a set of CSI sequences with varying voltages. Seventeen volunteers were scanned with 7 T phosphorus‐31 magnetic resonance spectroscopic imaging (31P‐MRSI). Reproducibility was assessed in nine of these volunteers. Strain was measured for six of these volunteers at 3 T. Results: Blood‐ and saturation‐corrected Phosphocreatine/γ‐adenosine triphosphate (PCr/ATP) ratios were measured for four regions of the left ventricle: 1.86 in septum, 2.25 in anterior wall, 1.41 in inferior wall, and 1.53 in lateral wall, respectively. These are in the expected range compared to previous studies. B1+ maps show good signal uniformity around the position of the heart (0.13 ± 0.06 μT/sqrt(W)). Intrasession and intersession coefficients of reproducibility were 0.22–0.88 and 0.29–0.79, respectively. Linear modeling shows that regional PCr/γATP correlates with circumferential strain but not radial strain. This requires corroboration by a larger study including patients with impaired function and energetics. Conclusion: Dipole‐loop array coils present a promising new approach for human cardiac 31P‐MRSI at 7 T. Their favorable B1+ uniformity at depth and specific absorption rate over loop arrays and improved SNR when combined with loops for reception could be beneficial for further clinical studies measuring energetics by 31P‐MRSI at 7 T. The new capability to assess PCr/γATP ratios across the whole left ventricle could enable clinical studies to investigate regional changes in cardiac energetics for the first time. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.30492
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        Text: English
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      – SubjectFull: Heart metabolism
        Type: general
      – SubjectFull: Spectroscopic imaging
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Heart failure
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      – SubjectFull: Volunteers
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      – TitleFull: Regionally resolved cardiac metabolism using a dipole‐loop array coil for 7 T 31P‐MRSI.
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              Text: Aug2025
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