Parallel detection of MRI and 1H MRSI for multi‐contrast anatomical and metabolic imaging.
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| Title: | Parallel detection of MRI and 1H MRSI for multi‐contrast anatomical and metabolic imaging. |
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| Authors: | de Graaf, Robin A.1,2 (AUTHOR) robin.degraaf@yale.edu, Thomas, Monique1 (AUTHOR), De Feyter, Henk M.1,2 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Aug2025, Vol. 94 Issue 2, p497-507. 11p. |
| Subjects: | Spectral sensitivity, Magnetic resonance imaging, Rats, Metabolites, Resonance |
| Abstract: | Purpose: MRI and MRSI provide unique and complementary information on anatomy, structure, function, and metabolism. The default strategy for a combined MRI and MRSI study is a sequential acquisition of both modalities, leading to long scan times. As MRI and MRSI primarily detect water and metabolites, respectively, the small frequency difference between resonances can be exploited with frequency‐selective RF pulses to achieve interleaved or parallel detection of MRI and MRSI, without an increase in total scan time. Methods: Here, we describe the pulse sequence modifications necessary to allow acquisition of T1 and T2‐weighted MRI and B0/B1 mapping in parallel with MRSI. In general, the MRSI module, including water suppression, can be used unmodified. MRI methods are executed in 3D using 3‐ to 4‐ms frequency‐selective Gaussian RF pulses with acceleration along the third dimension through repetitive small‐angle nutation or multi‐spin‐echo acquisitions. Results: Phantom experiments demonstrated artifact‐free 3D MRIs. MRSIs in the absence or presence of MRI elements were identical in sensitivity and spectral resolution (line width) and showed consistent water suppression. Parallel MRI‐MRSI was applied to the brains of tumor‐bearing rats in vivo. High‐contrast, high‐sensitivity metabolic MRSI data at 8 μL nominal resolution was acquired in parallel with 3D T1‐weighted, T2‐weighted, and B0/B1‐weighted MRIs for an overall scan duration of 30 min. Conclusion: Multi‐contrast MRIs and MRSI can be acquired in parallel by utilizing the small frequency difference between water and metabolites. This opens the possibility for shorter overall scans times, or the acquisition of higher‐resolution or additional contrast MRIs. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 185726158 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Parallel detection of MRI and <superscript>1</superscript>H MRSI for multi‐contrast anatomical and metabolic imaging. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22de+Graaf%2C+Robin+A%2E%22">de Graaf, Robin A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> robin.degraaf@yale.edu</i><br /><searchLink fieldCode="AR" term="%22Thomas%2C+Monique%22">Thomas, Monique</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Feyter%2C+Henk+M%2E%22">De Feyter, Henk M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Aug2025, Vol. 94 Issue 2, p497-507. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Spectral+sensitivity%22">Spectral sensitivity</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolites%22">Metabolites</searchLink><br /><searchLink fieldCode="DE" term="%22Resonance%22">Resonance</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: MRI and MRSI provide unique and complementary information on anatomy, structure, function, and metabolism. The default strategy for a combined MRI and MRSI study is a sequential acquisition of both modalities, leading to long scan times. As MRI and MRSI primarily detect water and metabolites, respectively, the small frequency difference between resonances can be exploited with frequency‐selective RF pulses to achieve interleaved or parallel detection of MRI and MRSI, without an increase in total scan time. Methods: Here, we describe the pulse sequence modifications necessary to allow acquisition of T1 and T2‐weighted MRI and B0/B1 mapping in parallel with MRSI. In general, the MRSI module, including water suppression, can be used unmodified. MRI methods are executed in 3D using 3‐ to 4‐ms frequency‐selective Gaussian RF pulses with acceleration along the third dimension through repetitive small‐angle nutation or multi‐spin‐echo acquisitions. Results: Phantom experiments demonstrated artifact‐free 3D MRIs. MRSIs in the absence or presence of MRI elements were identical in sensitivity and spectral resolution (line width) and showed consistent water suppression. Parallel MRI‐MRSI was applied to the brains of tumor‐bearing rats in vivo. High‐contrast, high‐sensitivity metabolic MRSI data at 8 μL nominal resolution was acquired in parallel with 3D T1‐weighted, T2‐weighted, and B0/B1‐weighted MRIs for an overall scan duration of 30 min. Conclusion: Multi‐contrast MRIs and MRSI can be acquired in parallel by utilizing the small frequency difference between water and metabolites. This opens the possibility for shorter overall scans times, or the acquisition of higher‐resolution or additional contrast MRIs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30501 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 497 Subjects: – SubjectFull: Spectral sensitivity Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Rats Type: general – SubjectFull: Metabolites Type: general – SubjectFull: Resonance Type: general Titles: – TitleFull: Parallel detection of MRI and 1H MRSI for multi‐contrast anatomical and metabolic imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: de Graaf, Robin A. – PersonEntity: Name: NameFull: Thomas, Monique – PersonEntity: Name: NameFull: De Feyter, Henk M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 94 – Type: issue Value: 2 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
