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Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation.

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Title: Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation.
Authors: Mukhangaliyeva, Lyazzat1 (AUTHOR), Alisherov, Shakhrizat2 (AUTHOR), Bessonov, Vladimir3 (AUTHOR), Ashikbayeva, Zhannat1,4 (AUTHOR), Molardi, Carlo2 (AUTHOR), Tosi, Daniele1,2 (AUTHOR) daniele.tosi@nu.edu.kz, Utegulov, Zhandos1,3 (AUTHOR) zhutegulov@nu.edu.kz
Source: Optics & Lasers in Engineering. Oct2025, Vol. 193, pN.PAG-N.PAG. 1p.
Subjects: Fiber Bragg gratings, Laser ablation, Laser heating, Brillouin scattering, Infrared heating, Gelation, Denaturation of proteins
Abstract: • Utilized hybrid technique by integrating Brillouin spectroscopy with fiber Bragg grating thermal mapping. • Conducted viscoelastic and temperature measurements on albumen and blood vessels in CAM models. • Validated CAM models as cost-effective tools to study biomechanical properties in-vivo. The laser ablation technique is commonly used in biomedicine to treat tumor cancerous tissues with minimal invasiveness to surrounding normal tissues. However, an accurate non-contact, real-time, in-situ, label-free thermomechanical measurement of affected tissues undergoing laser heating and ablation is virtually non-existent in clinical settings. In this work, we demonstrate real-time monitoring of local temperature and viscoelastic response of the albumen and blood vessels in chick chorioallantoic membrane (CAM) models during infrared laser heating and ablation by non-contact, label-free Brillouin light scattering (BLS) spectroscopy and fiber Bragg grating (FBG)-based thermal mapping. The albumen and CAM models were selected as ethical and cost-effective models with an easily accessible vasculature network to investigate changes in thermal and viscoelastic properties during laser-induced heating and ablation. Both studied biomaterials became stiffer and less viscous during laser-induced heating due to the thermal denaturation of proteins, forming cross-links with subsequent gelation (coagulation) and water evaporation (dehydration). Demonstrated hybrid BLS-FBG modality has a strong potential to equip conventional laser ablation therapy with accurate, real-time thermomechanical property-informed diagnostics to substantially improve patient outcomes. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:• Utilized hybrid technique by integrating Brillouin spectroscopy with fiber Bragg grating thermal mapping. • Conducted viscoelastic and temperature measurements on albumen and blood vessels in CAM models. • Validated CAM models as cost-effective tools to study biomechanical properties in-vivo. The laser ablation technique is commonly used in biomedicine to treat tumor cancerous tissues with minimal invasiveness to surrounding normal tissues. However, an accurate non-contact, real-time, in-situ, label-free thermomechanical measurement of affected tissues undergoing laser heating and ablation is virtually non-existent in clinical settings. In this work, we demonstrate real-time monitoring of local temperature and viscoelastic response of the albumen and blood vessels in chick chorioallantoic membrane (CAM) models during infrared laser heating and ablation by non-contact, label-free Brillouin light scattering (BLS) spectroscopy and fiber Bragg grating (FBG)-based thermal mapping. The albumen and CAM models were selected as ethical and cost-effective models with an easily accessible vasculature network to investigate changes in thermal and viscoelastic properties during laser-induced heating and ablation. Both studied biomaterials became stiffer and less viscous during laser-induced heating due to the thermal denaturation of proteins, forming cross-links with subsequent gelation (coagulation) and water evaporation (dehydration). Demonstrated hybrid BLS-FBG modality has a strong potential to equip conventional laser ablation therapy with accurate, real-time thermomechanical property-informed diagnostics to substantially improve patient outcomes. [ABSTRACT FROM AUTHOR]
ISSN:01438166
DOI:10.1016/j.optlaseng.2025.109116