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Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation.

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Title: Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation.
Authors: Mukhangaliyeva, Lyazzat1 (AUTHOR), Alisherov, Shakhrizat2 (AUTHOR), Bessonov, Vladimir3 (AUTHOR), Ashikbayeva, Zhannat1,4 (AUTHOR), Molardi, Carlo2 (AUTHOR), Tosi, Daniele1,2 (AUTHOR) daniele.tosi@nu.edu.kz, Utegulov, Zhandos1,3 (AUTHOR) zhutegulov@nu.edu.kz
Source: Optics & Lasers in Engineering. Oct2025, Vol. 193, pN.PAG-N.PAG. 1p.
Subjects: Fiber Bragg gratings, Laser ablation, Laser heating, Brillouin scattering, Infrared heating, Gelation, Denaturation of proteins
Abstract: • Utilized hybrid technique by integrating Brillouin spectroscopy with fiber Bragg grating thermal mapping. • Conducted viscoelastic and temperature measurements on albumen and blood vessels in CAM models. • Validated CAM models as cost-effective tools to study biomechanical properties in-vivo. The laser ablation technique is commonly used in biomedicine to treat tumor cancerous tissues with minimal invasiveness to surrounding normal tissues. However, an accurate non-contact, real-time, in-situ, label-free thermomechanical measurement of affected tissues undergoing laser heating and ablation is virtually non-existent in clinical settings. In this work, we demonstrate real-time monitoring of local temperature and viscoelastic response of the albumen and blood vessels in chick chorioallantoic membrane (CAM) models during infrared laser heating and ablation by non-contact, label-free Brillouin light scattering (BLS) spectroscopy and fiber Bragg grating (FBG)-based thermal mapping. The albumen and CAM models were selected as ethical and cost-effective models with an easily accessible vasculature network to investigate changes in thermal and viscoelastic properties during laser-induced heating and ablation. Both studied biomaterials became stiffer and less viscous during laser-induced heating due to the thermal denaturation of proteins, forming cross-links with subsequent gelation (coagulation) and water evaporation (dehydration). Demonstrated hybrid BLS-FBG modality has a strong potential to equip conventional laser ablation therapy with accurate, real-time thermomechanical property-informed diagnostics to substantially improve patient outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Optics & Lasers in Engineering is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 185772026
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation.
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  Data: <searchLink fieldCode="AR" term="%22Mukhangaliyeva%2C+Lyazzat%22">Mukhangaliyeva, Lyazzat</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alisherov%2C+Shakhrizat%22">Alisherov, Shakhrizat</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bessonov%2C+Vladimir%22">Bessonov, Vladimir</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ashikbayeva%2C+Zhannat%22">Ashikbayeva, Zhannat</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Molardi%2C+Carlo%22">Molardi, Carlo</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tosi%2C+Daniele%22">Tosi, Daniele</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> daniele.tosi@nu.edu.kz</i><br /><searchLink fieldCode="AR" term="%22Utegulov%2C+Zhandos%22">Utegulov, Zhandos</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> zhutegulov@nu.edu.kz</i>
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  Data: <searchLink fieldCode="JN" term="%22Optics+%26+Lasers+in+Engineering%22">Optics & Lasers in Engineering</searchLink>. Oct2025, Vol. 193, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Fiber+Bragg+gratings%22">Fiber Bragg gratings</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+ablation%22">Laser ablation</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+heating%22">Laser heating</searchLink><br /><searchLink fieldCode="DE" term="%22Brillouin+scattering%22">Brillouin scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Infrared+heating%22">Infrared heating</searchLink><br /><searchLink fieldCode="DE" term="%22Gelation%22">Gelation</searchLink><br /><searchLink fieldCode="DE" term="%22Denaturation+of+proteins%22">Denaturation of proteins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • Utilized hybrid technique by integrating Brillouin spectroscopy with fiber Bragg grating thermal mapping. • Conducted viscoelastic and temperature measurements on albumen and blood vessels in CAM models. • Validated CAM models as cost-effective tools to study biomechanical properties in-vivo. The laser ablation technique is commonly used in biomedicine to treat tumor cancerous tissues with minimal invasiveness to surrounding normal tissues. However, an accurate non-contact, real-time, in-situ, label-free thermomechanical measurement of affected tissues undergoing laser heating and ablation is virtually non-existent in clinical settings. In this work, we demonstrate real-time monitoring of local temperature and viscoelastic response of the albumen and blood vessels in chick chorioallantoic membrane (CAM) models during infrared laser heating and ablation by non-contact, label-free Brillouin light scattering (BLS) spectroscopy and fiber Bragg grating (FBG)-based thermal mapping. The albumen and CAM models were selected as ethical and cost-effective models with an easily accessible vasculature network to investigate changes in thermal and viscoelastic properties during laser-induced heating and ablation. Both studied biomaterials became stiffer and less viscous during laser-induced heating due to the thermal denaturation of proteins, forming cross-links with subsequent gelation (coagulation) and water evaporation (dehydration). Demonstrated hybrid BLS-FBG modality has a strong potential to equip conventional laser ablation therapy with accurate, real-time thermomechanical property-informed diagnostics to substantially improve patient outcomes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Optics & Lasers in Engineering is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.optlaseng.2025.109116
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Fiber Bragg gratings
        Type: general
      – SubjectFull: Laser ablation
        Type: general
      – SubjectFull: Laser heating
        Type: general
      – SubjectFull: Brillouin scattering
        Type: general
      – SubjectFull: Infrared heating
        Type: general
      – SubjectFull: Gelation
        Type: general
      – SubjectFull: Denaturation of proteins
        Type: general
    Titles:
      – TitleFull: Real-time optical in-vivo thermo-viscoelastometry of albumen and blood vessels in chicken embryo models under laser heating and ablation.
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            NameFull: Mukhangaliyeva, Lyazzat
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            NameFull: Alisherov, Shakhrizat
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            NameFull: Bessonov, Vladimir
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            NameFull: Molardi, Carlo
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            – D: 01
              M: 10
              Text: Oct2025
              Type: published
              Y: 2025
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              Value: 01438166
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              Value: 193
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            – TitleFull: Optics & Lasers in Engineering
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