Clinical investigation of levels of lipopolysaccharides and lipoteichoic acid after antimicrobial photodynamic therapy in teeth with secondary endodontic infection: an observational study.
Saved in:
| Title: | Clinical investigation of levels of lipopolysaccharides and lipoteichoic acid after antimicrobial photodynamic therapy in teeth with secondary endodontic infection: an observational study. |
|---|---|
| Authors: | KC, Dhaniba1 (AUTHOR) dhanibakc15@gmail.com, Bharti, Ramesh1 (AUTHOR) rameshbharti@kgmcindia.edu, Verma, Promila1 (AUTHOR) promilarajesh@yahoo.co.in, Tikku, Aseem P1 (AUTHOR) crown_tikku@yahoo.com, Pandey, Pragya1 (AUTHOR) w.pragya78@gmail.com, Gupta, Prashant2 (AUTHOR) prashantgupta46@hotmail.com, Singh, Nishi1 (AUTHOR) nishibp003@gmail.com |
| Source: | Lasers in Medical Science. 6/10/2025, Vol. 40 Issue 1, p1-8. 8p. |
| Subjects: | Lipoteichoic acid, Statistical hypothesis testing, Photodynamic therapy, Asymptomatic patients, Periapical periodontitis |
| Abstract: | Introduction: This study aimed to evaluate the effectiveness of photodynamic therapy (PDT) in reducing lipopolysaccharides (LPS) and lipoteichoic acid (LTA) levels in secondary endodontic infections and assess their correlation with clinical symptoms. Materials & methods: Seventy patients requiring nonsurgical endodontic retreatment were selected for this study and divided into two groups: one group received photodynamic therapy (PDT), while the other was treated with sodium hypochlorite (NaOCl). Using ELISA and chromogenic assays, endodontic samples were collected to measure lipoteichoic acid (LTA) levels and lipopolysaccharides (LPS). Strict aseptic techniques and contamination prevention measures were adhered to throughout the procedures. The data were analyzed using SPSS version 26, applying descriptive statistics and significance tests with a p-value threshold of 0.05, a 95% confidence level, and 80% power. Results: The study found that photodynamic therapy significantly reduced lipoteichoic acid and lipopolysaccharides levels compared to sodium hypochlorite irrigation, with mean changes of 253.78 and 154.35 (p = 0.02). Additionally, a significant mean reduction in lipopolysaccharide levels favored PDT (p = 0.013). Symptomatic patients exhibited a higher mean level of lipoteichoic acid (507.48) than asymptomatic patients (210.14, p = 0.001). However, no significant correlation was found between lipopolysaccharide levels and symptoms (p = 0.606). Endodontic infections and to assess their correlation with clinical symptoms. Conclusion: This study shows that photodynamic therapy (PDT) significantly reduces lipoteichoic acid and lipopolysaccharides levels, outperforming sodium hypochlorite irrigation in secondary apical periodontitis management. It also reveals a strong correlation between higher lipoteichoic acid levels and clinical symptoms, with no significant link found for lipopolysaccharide levels. [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 185842418 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Clinical investigation of levels of lipopolysaccharides and lipoteichoic acid after antimicrobial photodynamic therapy in teeth with secondary endodontic infection: an observational study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22KC%2C+Dhaniba%22">KC, Dhaniba</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dhanibakc15@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Bharti%2C+Ramesh%22">Bharti, Ramesh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rameshbharti@kgmcindia.edu</i><br /><searchLink fieldCode="AR" term="%22Verma%2C+Promila%22">Verma, Promila</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> promilarajesh@yahoo.co.in</i><br /><searchLink fieldCode="AR" term="%22Tikku%2C+Aseem+P%22">Tikku, Aseem P</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> crown_tikku@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Pragya%22">Pandey, Pragya</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> w.pragya78@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Gupta%2C+Prashant%22">Gupta, Prashant</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> prashantgupta46@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Singh%2C+Nishi%22">Singh, Nishi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> nishibp003@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 6/10/2025, Vol. 40 Issue 1, p1-8. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lipoteichoic+acid%22">Lipoteichoic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22Photodynamic+therapy%22">Photodynamic therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Asymptomatic+patients%22">Asymptomatic patients</searchLink><br /><searchLink fieldCode="DE" term="%22Periapical+periodontitis%22">Periapical periodontitis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: This study aimed to evaluate the effectiveness of photodynamic therapy (PDT) in reducing lipopolysaccharides (LPS) and lipoteichoic acid (LTA) levels in secondary endodontic infections and assess their correlation with clinical symptoms. Materials & methods: Seventy patients requiring nonsurgical endodontic retreatment were selected for this study and divided into two groups: one group received photodynamic therapy (PDT), while the other was treated with sodium hypochlorite (NaOCl). Using ELISA and chromogenic assays, endodontic samples were collected to measure lipoteichoic acid (LTA) levels and lipopolysaccharides (LPS). Strict aseptic techniques and contamination prevention measures were adhered to throughout the procedures. The data were analyzed using SPSS version 26, applying descriptive statistics and significance tests with a p-value threshold of 0.05, a 95% confidence level, and 80% power. Results: The study found that photodynamic therapy significantly reduced lipoteichoic acid and lipopolysaccharides levels compared to sodium hypochlorite irrigation, with mean changes of 253.78 and 154.35 (p = 0.02). Additionally, a significant mean reduction in lipopolysaccharide levels favored PDT (p = 0.013). Symptomatic patients exhibited a higher mean level of lipoteichoic acid (507.48) than asymptomatic patients (210.14, p = 0.001). However, no significant correlation was found between lipopolysaccharide levels and symptoms (p = 0.606). Endodontic infections and to assess their correlation with clinical symptoms. Conclusion: This study shows that photodynamic therapy (PDT) significantly reduces lipoteichoic acid and lipopolysaccharides levels, outperforming sodium hypochlorite irrigation in secondary apical periodontitis management. It also reveals a strong correlation between higher lipoteichoic acid levels and clinical symptoms, with no significant link found for lipopolysaccharide levels. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=185842418 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-025-04523-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1 Subjects: – SubjectFull: Lipoteichoic acid Type: general – SubjectFull: Statistical hypothesis testing Type: general – SubjectFull: Photodynamic therapy Type: general – SubjectFull: Asymptomatic patients Type: general – SubjectFull: Periapical periodontitis Type: general Titles: – TitleFull: Clinical investigation of levels of lipopolysaccharides and lipoteichoic acid after antimicrobial photodynamic therapy in teeth with secondary endodontic infection: an observational study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: KC, Dhaniba – PersonEntity: Name: NameFull: Bharti, Ramesh – PersonEntity: Name: NameFull: Verma, Promila – PersonEntity: Name: NameFull: Tikku, Aseem P – PersonEntity: Name: NameFull: Pandey, Pragya – PersonEntity: Name: NameFull: Gupta, Prashant – PersonEntity: Name: NameFull: Singh, Nishi IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 06 Text: 6/10/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 40 – Type: issue Value: 1 Titles: – TitleFull: Lasers in Medical Science Type: main |
| ResultId | 1 |
