Newly Synthesized CoFe 2−y Pr y O 4 (y = 0; 0.01; 0.03; 0.05; 0.1; 0.15; 0.2) Nanoparticles Reveal Promising Selective Anticancer Activity Against Melanoma (A375), Breast Cancer (MCF-7), and Colon Cancer (HT-29) Cells.
Saved in:
| Title: | Newly Synthesized CoFe 2−y Pr y O 4 (y = 0; 0.01; 0.03; 0.05; 0.1; 0.15; 0.2) Nanoparticles Reveal Promising Selective Anticancer Activity Against Melanoma (A375), Breast Cancer (MCF-7), and Colon Cancer (HT-29) Cells. |
|---|---|
| Authors: | Rotunjanu, Slaviţa1,2 (AUTHOR), Racoviceanu, Roxana2,3 (AUTHOR), Gogulescu, Armand3,4 (AUTHOR) gogulescu.armand@umft.ro, Mioc, Alexandra1,2,4 (AUTHOR), Milan, Andreea2,3,5 (AUTHOR), Marangoci, Narcisa Laura1,5 (AUTHOR), Dascălu, Andrei-Ioan2,5 (AUTHOR), Mioc, Marius2,3 (AUTHOR), Negrea-Ghiulai, Roxana1,2,4 (AUTHOR), Trandafirescu, Cristina3,5 (AUTHOR), Șoica, Codruţa1,2 (AUTHOR) |
| Source: | Nanomaterials (2079-4991). Jun2025, Vol. 15 Issue 11, p829. 22p. |
| Subjects: | Magnetic nanoparticles, Colon cancer, Fourier transform infrared spectroscopy, Cyclodextrins, Cytotoxins |
| Abstract: | In this study, praseodymium-doped cobalt ferrite nanoparticles (CoFe2−yPryO4, y = 0–0.2) were synthesized via sol-gel auto-combustion and systematically characterized to assess their structural, morphological, magnetic, and biological properties. X-ray diffraction (XRD) confirmed single-phase cubic cobalt ferrite formation for samples with y ≤ 0.05 and the emergence of a secondary orthorhombic PrFeO3 phase at higher dopant concentrations. FTIR spectroscopy identified characteristic metal–oxygen vibrations and revealed a progressive shift of absorption bands with increasing praseodymium (Pr) content. Vibrating sample magnetometry (VSM) demonstrated a gradual decline in saturation (Ms) and remanent (Mr) magnetization with Pr doping, an effect further intensified by cyclodextrin surface coating. TEM analyses revealed a particle size increase correlated with dopant level, while SEM images displayed a porous morphology typical of combustion-synthesized ferrites. In vitro cell viability assays showed minimal toxicity in normal human keratinocytes (HaCaT), while significant antiproliferative activity was observed against human cancer cell lines A375 (melanoma), MCF-7 (breast adenocarcinoma), and HT-29 (colorectal adenocarcinoma), particularly in Pr 6-CD and Pr 7-CD samples. These findings suggest that Pr substitution and cyclodextrin coating can effectively modulate the physicochemical and anticancer properties of cobalt ferrite nanoparticles, making them promising candidates for future biomedical applications. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
|
Full text is not displayed to guests.
Login for full access.
|
|
Be the first to leave a comment!
