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The Use of Cyanoacrylate and Glubran in Dentistry: A Review of Clinical Applications and Outcomes.

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Title: The Use of Cyanoacrylate and Glubran in Dentistry: A Review of Clinical Applications and Outcomes.
Authors: Miranda, Michele1 (AUTHOR) michelemiranda.ptv@gmail.com, Gianfreda, Francesco1,2 (AUTHOR), Molica, Graziana1 (AUTHOR), Martelli, Mirko1,2 (AUTHOR), Gargari, Marco1 (AUTHOR), Bollero, Patrizio2 (AUTHOR)
Source: Materials (1996-1944). Jun2025, Vol. 18 Issue 11, p2642. 19p.
Subjects: Operative dentistry, Oral surgery, Cyanoacrylates, Web databases, Science databases
Abstract: Cyanoacrylate-based adhesives have gained increasing attention in dentistry for their rapid polymerization, biocompatibility, and antimicrobial activity. This review analyzes the clinical use of cyanoacrylate adhesives—particularly the Glubran II formulation—in dental procedures, including wound closure, tissue management, and bleeding control. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases for studies published between 2000 and 2024, using specific inclusion criteria (clinical and in vitro studies focusing on dental applications of cyanoacrylates) and exclusion criteria (non-dental uses, insufficient data). The findings indicate that compared to traditional sutures, cyanoacrylates, especially n-butyl and octyl derivatives, significantly reduce operative time, postoperative pain, and infection rates. However, differences among formulations—such as degradation rate and cytotoxicity—require further exploration. Glubran II, in particular, shows promising results in hemostasis and wound stability. This review highlights the potential of cyanoacrylate adhesives as effective, minimally invasive alternatives in dental surgery and underlines the need for standardized protocols and long-term comparative studies. [ABSTRACT FROM AUTHOR]
Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Label: Title
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  Data: The Use of Cyanoacrylate and Glubran in Dentistry: A Review of Clinical Applications and Outcomes.
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  Data: <searchLink fieldCode="AR" term="%22Miranda%2C+Michele%22">Miranda, Michele</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> michelemiranda.ptv@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Gianfreda%2C+Francesco%22">Gianfreda, Francesco</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Molica%2C+Graziana%22">Molica, Graziana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martelli%2C+Mirko%22">Martelli, Mirko</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gargari%2C+Marco%22">Gargari, Marco</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bollero%2C+Patrizio%22">Bollero, Patrizio</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Materials+%281996-1944%29%22">Materials (1996-1944)</searchLink>. Jun2025, Vol. 18 Issue 11, p2642. 19p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Operative+dentistry%22">Operative dentistry</searchLink><br /><searchLink fieldCode="DE" term="%22Oral+surgery%22">Oral surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Cyanoacrylates%22">Cyanoacrylates</searchLink><br /><searchLink fieldCode="DE" term="%22Web+databases%22">Web databases</searchLink><br /><searchLink fieldCode="DE" term="%22Science+databases%22">Science databases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cyanoacrylate-based adhesives have gained increasing attention in dentistry for their rapid polymerization, biocompatibility, and antimicrobial activity. This review analyzes the clinical use of cyanoacrylate adhesives—particularly the Glubran II formulation—in dental procedures, including wound closure, tissue management, and bleeding control. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases for studies published between 2000 and 2024, using specific inclusion criteria (clinical and in vitro studies focusing on dental applications of cyanoacrylates) and exclusion criteria (non-dental uses, insufficient data). The findings indicate that compared to traditional sutures, cyanoacrylates, especially n-butyl and octyl derivatives, significantly reduce operative time, postoperative pain, and infection rates. However, differences among formulations—such as degradation rate and cytotoxicity—require further exploration. Glubran II, in particular, shows promising results in hemostasis and wound stability. This review highlights the potential of cyanoacrylate adhesives as effective, minimally invasive alternatives in dental surgery and underlines the need for standardized protocols and long-term comparative studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/ma18112642
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        Text: English
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      – SubjectFull: Operative dentistry
        Type: general
      – SubjectFull: Oral surgery
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      – SubjectFull: Cyanoacrylates
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      – SubjectFull: Web databases
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      – SubjectFull: Science databases
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      – TitleFull: The Use of Cyanoacrylate and Glubran in Dentistry: A Review of Clinical Applications and Outcomes.
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            NameFull: Miranda, Michele
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            NameFull: Gianfreda, Francesco
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            NameFull: Molica, Graziana
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            NameFull: Martelli, Mirko
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            NameFull: Gargari, Marco
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              M: 06
              Text: Jun2025
              Type: published
              Y: 2025
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