Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening.
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| Title: | Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening. |
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| Authors: | Nie, Zhenhui1 (AUTHOR), Vonder, Marleen1 (AUTHOR), de Vries, Maaike1,2 (AUTHOR), Yang, Xiaofei1 (AUTHOR), Oudkerk, Matthijs3 (AUTHOR), Slebos, Dirk-Jan2,4 (AUTHOR), Ye, Zhaoxiang5 (AUTHOR), Dorrius, Monique D.6 (AUTHOR), de Bock, Geertruida H.1 (AUTHOR) g.h.de.bock@umcg.nl |
| Source: | European Radiology. Jul2025, Vol. 35 Issue 7, p3823-3832. 10p. |
| Subjects: | Bronchiectasis, Pulmonary emphysema, Lung cancer, Disease risk factors, Airway (Anatomy), Diagnosis, Chinese people |
| Abstract: | Objective: To assess the co-occurrence of incidental CT lung findings (emphysema, bronchiectasis, and airway wall thickening) as well as associated risk factors in low-dose CT (LDCT) lung cancer screening in a Chinese urban population. Methods: Data from 978 participants aged 40–74 years from the Chinese NELCIN-B3 urban population study who underwent LDCT screening were selected. CT scans were reviewed for incidental lung findings: emphysema, bronchiectasis and airway wall thickness. Emphysema was defined in three ways (≥ trace, ≥ mild, or ≥ moderate) depending on severity. Participants were described and stratified by presence or absence of incidental lung findings. Logistic regression analyses were performed to examine the relationship between participant characteristics and CT findings. Results: Mean age was 61.3 years ± 6.8 and 533 (54.6%) were female. 48% of participants had incidental lung findings: 19.9% had emphysema (≥ mild), 9.2% had bronchiectasis, and 35.7% had airway wall thickening. Among 978 participants, 2.1% showed all three findings. Multivariable analysis showed that higher age (OR: 1.06; 95% CI: 1.04–1.08; p < 0.001), male sex (OR: 1.68; 95% CI: 1.14–2.47; p = 0.008) smoking history (OR: 1.76; 95% CI: 1.02–3.03; p = 0.04 for former smokers; OR: 2.45; 95% CI: 1.59–3.78; p < 0.001 for current smokers), and the presence of respiratory symptoms (OR: 1.42; 95% CI: 1.01–2.00; p = 0.04) were associated with the risk of having at least one incidental lung findings. When different definitions of emphysema were used, the results remained consistent. Conclusion: In a Chinese urban population undergoing LDCT lung cancer screening, 48% had at least one incidental CT lung finding, which was associated with higher age, male sex, questionnaire-based respiratory symptoms and smoking history. Key Points: QuestionReporting of incidental lung findings that indicate lung disease risk lacks consensus in the cancer screening setting and needs evidence of co-occurrence in general populations. FindingsAlmost half of the 978 participants had at least one incidental lung CT finding; these were associated with older age, male sex, respiratory symptoms, and smoking history. Clinical relevanceIncidental lung findings and related risk factors are often observed in low-dose CT lung cancer screening, and careful consideration of their relevance should be given to their inclusion in future screenings. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nie%2C+Zhenhui%22">Nie, Zhenhui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vonder%2C+Marleen%22">Vonder, Marleen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Vries%2C+Maaike%22">de Vries, Maaike</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xiaofei%22">Yang, Xiaofei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oudkerk%2C+Matthijs%22">Oudkerk, Matthijs</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Slebos%2C+Dirk-Jan%22">Slebos, Dirk-Jan</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Zhaoxiang%22">Ye, Zhaoxiang</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dorrius%2C+Monique+D%2E%22">Dorrius, Monique D.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Bock%2C+Geertruida+H%2E%22">de Bock, Geertruida H.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> g.h.de.bock@umcg.nl</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jul2025, Vol. 35 Issue 7, p3823-3832. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Bronchiectasis%22">Bronchiectasis</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+emphysema%22">Pulmonary emphysema</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+cancer%22">Lung cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Airway+%28Anatomy%29%22">Airway (Anatomy)</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Chinese+people%22">Chinese people</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: To assess the co-occurrence of incidental CT lung findings (emphysema, bronchiectasis, and airway wall thickening) as well as associated risk factors in low-dose CT (LDCT) lung cancer screening in a Chinese urban population. Methods: Data from 978 participants aged 40–74 years from the Chinese NELCIN-B3 urban population study who underwent LDCT screening were selected. CT scans were reviewed for incidental lung findings: emphysema, bronchiectasis and airway wall thickness. Emphysema was defined in three ways (≥ trace, ≥ mild, or ≥ moderate) depending on severity. Participants were described and stratified by presence or absence of incidental lung findings. Logistic regression analyses were performed to examine the relationship between participant characteristics and CT findings. Results: Mean age was 61.3 years ± 6.8 and 533 (54.6%) were female. 48% of participants had incidental lung findings: 19.9% had emphysema (≥ mild), 9.2% had bronchiectasis, and 35.7% had airway wall thickening. Among 978 participants, 2.1% showed all three findings. Multivariable analysis showed that higher age (OR: 1.06; 95% CI: 1.04–1.08; p < 0.001), male sex (OR: 1.68; 95% CI: 1.14–2.47; p = 0.008) smoking history (OR: 1.76; 95% CI: 1.02–3.03; p = 0.04 for former smokers; OR: 2.45; 95% CI: 1.59–3.78; p < 0.001 for current smokers), and the presence of respiratory symptoms (OR: 1.42; 95% CI: 1.01–2.00; p = 0.04) were associated with the risk of having at least one incidental lung findings. When different definitions of emphysema were used, the results remained consistent. Conclusion: In a Chinese urban population undergoing LDCT lung cancer screening, 48% had at least one incidental CT lung finding, which was associated with higher age, male sex, questionnaire-based respiratory symptoms and smoking history. Key Points: QuestionReporting of incidental lung findings that indicate lung disease risk lacks consensus in the cancer screening setting and needs evidence of co-occurrence in general populations. FindingsAlmost half of the 978 participants had at least one incidental lung CT finding; these were associated with older age, male sex, respiratory symptoms, and smoking history. Clinical relevanceIncidental lung findings and related risk factors are often observed in low-dose CT lung cancer screening, and careful consideration of their relevance should be given to their inclusion in future screenings. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-024-11231-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 3823 Subjects: – SubjectFull: Bronchiectasis Type: general – SubjectFull: Pulmonary emphysema Type: general – SubjectFull: Lung cancer Type: general – SubjectFull: Disease risk factors Type: general – SubjectFull: Airway (Anatomy) Type: general – SubjectFull: Diagnosis Type: general – SubjectFull: Chinese people Type: general Titles: – TitleFull: Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nie, Zhenhui – PersonEntity: Name: NameFull: Vonder, Marleen – PersonEntity: Name: NameFull: de Vries, Maaike – PersonEntity: Name: NameFull: Yang, Xiaofei – PersonEntity: Name: NameFull: Oudkerk, Matthijs – PersonEntity: Name: NameFull: Slebos, Dirk-Jan – PersonEntity: Name: NameFull: Ye, Zhaoxiang – PersonEntity: Name: NameFull: Dorrius, Monique D. – PersonEntity: Name: NameFull: de Bock, Geertruida H. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 7 Titles: – TitleFull: European Radiology Type: main |
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