Reproducibility of liver iron concentration measured by R2* method based on 1.5-T MRI: a meta-analysis.
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| Title: | Reproducibility of liver iron concentration measured by R2* method based on 1.5-T MRI: a meta-analysis. |
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| Authors: | Cao, Sue1 (AUTHOR), Zhang, Jie1 (AUTHOR), Dong, Chenyu1 (AUTHOR), Que, Yutao1 (AUTHOR), Gao, Xin1 (AUTHOR), Guo, Ruomi1 (AUTHOR) guoruomi86@mail.sysu.edu.cn |
| Source: | European Radiology. Jul2025, Vol. 35 Issue 7, p3768-3780. 13p. |
| Subjects: | Imaging systems, Magnetic resonance imaging, Image analysis, Diagnostic services, Reproducible research |
| Abstract: | Objectives: To explore the reproducibility of the 1.5-T MR imaging (MRI)-based R2* method in measuring the liver iron concentration (LIC) across different MRI scanners, scan parameters, and postprocessing techniques. Materials and methods: We performed a systematic search of the PubMed, Embase, Medline, Cochrane Library, and Web of Science databases and identified studies that used the 1.5-T MRI-based R2* method to measure the LIC. The original data were extracted from the selected studies. Reproducibility was assessed in terms of the ability to replicate the measured LIC with the 1.5-T MRI-based R2* method across different scanning instruments, scan parameters, and postprocessing techniques. We used the scanner equipment, scan parameters, and postprocessing technique as random effects to determine whether the R2* values obtained in the different studies were significantly different after the effects of the measured LIC were excluded. The calibration curve that best fit the R2* value to the LIC was estimated via univariate regression. Results: Twenty-one studies (1147 participants) were included. The seven studies (435 participants) in which the initial TE was ≤ 1.0 ms and the TE spacing was ≤ 1.4 ms did not have significant differences in the measured R2* value in pairwise comparisons (p > 0.05). Calibration of R2* to LIC was as follows: LIC (mg/g) = 0.042 + 2.85 × 10−2 R2* (s−1) (R2 = 0.79). Conclusion: The 1.5-T MRI-based R2* method in estimating LIC was reproducible across different MRI scanners, scan parameters, and postprocessing techniques. Key Points: QuestionThe R2* method is widely used to quantify LIC, but the reproducibility of R2*-based LIC estimation remains unknown. FindingsIn scan sequences with an initial echo time (TE) ≤ 1.0 ms and a TE spacing ≤ 1.4 ms, the R2*-based LIC quantification at 1.5 T achieved good reproducibility. Clinical relevanceThe 1.5-T MRI-based R2* method enables reproducible quantification of the LIC; its reproducibility spares patients from unnecessary trauma and economic burdens while promoting the extensive clinical dissemination of R2*-based LIC quantification methods. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 185942226 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Reproducibility of liver iron concentration measured by R2* method based on 1.5-T MRI: a meta-analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Cao%2C+Sue%22">Cao, Sue</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jie%22">Zhang, Jie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dong%2C+Chenyu%22">Dong, Chenyu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Que%2C+Yutao%22">Que, Yutao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Xin%22">Gao, Xin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Ruomi%22">Guo, Ruomi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> guoruomi86@mail.sysu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jul2025, Vol. 35 Issue 7, p3768-3780. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Imaging+systems%22">Imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Image+analysis%22">Image analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+services%22">Diagnostic services</searchLink><br /><searchLink fieldCode="DE" term="%22Reproducible+research%22">Reproducible research</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: To explore the reproducibility of the 1.5-T MR imaging (MRI)-based R2* method in measuring the liver iron concentration (LIC) across different MRI scanners, scan parameters, and postprocessing techniques. Materials and methods: We performed a systematic search of the PubMed, Embase, Medline, Cochrane Library, and Web of Science databases and identified studies that used the 1.5-T MRI-based R2* method to measure the LIC. The original data were extracted from the selected studies. Reproducibility was assessed in terms of the ability to replicate the measured LIC with the 1.5-T MRI-based R2* method across different scanning instruments, scan parameters, and postprocessing techniques. We used the scanner equipment, scan parameters, and postprocessing technique as random effects to determine whether the R2* values obtained in the different studies were significantly different after the effects of the measured LIC were excluded. The calibration curve that best fit the R2* value to the LIC was estimated via univariate regression. Results: Twenty-one studies (1147 participants) were included. The seven studies (435 participants) in which the initial TE was ≤ 1.0 ms and the TE spacing was ≤ 1.4 ms did not have significant differences in the measured R2* value in pairwise comparisons (p > 0.05). Calibration of R2* to LIC was as follows: LIC (mg/g) = 0.042 + 2.85 × 10−2 R2* (s−1) (R2 = 0.79). Conclusion: The 1.5-T MRI-based R2* method in estimating LIC was reproducible across different MRI scanners, scan parameters, and postprocessing techniques. Key Points: QuestionThe R2* method is widely used to quantify LIC, but the reproducibility of R2*-based LIC estimation remains unknown. FindingsIn scan sequences with an initial echo time (TE) ≤ 1.0 ms and a TE spacing ≤ 1.4 ms, the R2*-based LIC quantification at 1.5 T achieved good reproducibility. Clinical relevanceThe 1.5-T MRI-based R2* method enables reproducible quantification of the LIC; its reproducibility spares patients from unnecessary trauma and economic burdens while promoting the extensive clinical dissemination of R2*-based LIC quantification methods. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-024-11334-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 3768 Subjects: – SubjectFull: Imaging systems Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Image analysis Type: general – SubjectFull: Diagnostic services Type: general – SubjectFull: Reproducible research Type: general Titles: – TitleFull: Reproducibility of liver iron concentration measured by R2* method based on 1.5-T MRI: a meta-analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cao, Sue – PersonEntity: Name: NameFull: Zhang, Jie – PersonEntity: Name: NameFull: Dong, Chenyu – PersonEntity: Name: NameFull: Que, Yutao – PersonEntity: Name: NameFull: Gao, Xin – PersonEntity: Name: NameFull: Guo, Ruomi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 35 – Type: issue Value: 7 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
