Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication.
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| Title: | Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication. |
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| Authors: | Akanda, Shamimur R.1 (AUTHOR), Kupratis, Meghan E.2 (AUTHOR), Bhattacharjee, Arnab1 (AUTHOR), Benson, Jamie2 (AUTHOR), Burris, David L.1,2 (AUTHOR), Price, Christopher1,2 (AUTHOR) cprice@udel.edu |
| Source: | Annals of Biomedical Engineering. Jul2025, Vol. 53 Issue 7, p1672-1688. 17p. |
| Subjects: | Articular cartilage, Dead loads (Mechanics), Extracellular fluid, Medical sciences, Exudation (Botany) |
| Abstract: | Purpose: Understanding how obesity—a key risk factor for osteoarthritis—effects articular cartilage function is critical to understand OA pathoetiology. Cartilage, a biphasic material, supports vanishingly low friction coefficients in vivo, but is tribomechanically compromised by load-induced interstitial pressure/lubrication loss. To maintain tribomechanical function, cartilage must recover fluid lost to habitual/average contact stresses, a problem obesity likely exacerbates. Recently, we have shown that articulation/sliding drives robust interstitial fluid recovery and indefinite maintenance of biofidelic tissue strains and frictions through generation of hydrodynamic pressures within cartilage contact interfaces, i.e., via 'tribological rehydration.' However, the impact of elevated contact stresses on tribological rehydration and cartilage's function/lubrication remains unknown. Methods: Using our convergent stationary contact area (cSCA) testing approach on ovine stifle cartilage explants bathed in PBS, we aimed to elucidate several points: (1) the effect of elevated contact stress on tribological rehydration during high-speed articulation, and how (2) cartilage material properties and (3) sliding speed influence contact stress-dependent fluid exudation, rehydration, and lubrication. Results: Overall, we identified that (i) contact stress, across a narrow range, and (ii) static loading time are key controllers of tribological rehydration magnitude, compression accumulation, and equilibrium/total compression under biofidelic cSCA loading and sliding conditions. However, over the range tested (i.e., 0.2–0.8 MPa), (iii) contact stresses had no appreciable effect on cartilage's remarkable lubricity in the cSCA. Conclusions: These results show that obesity is likely to directly physically impair articular cartilage function, and that obesity-driven tissue compression/strain, and not friction per se, may be the primary mechanical driver of cartilage dysfunction and OA risk. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Akanda%2C+Shamimur+R%2E%22">Akanda, Shamimur R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kupratis%2C+Meghan+E%2E%22">Kupratis, Meghan E.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhattacharjee%2C+Arnab%22">Bhattacharjee, Arnab</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benson%2C+Jamie%22">Benson, Jamie</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burris%2C+David+L%2E%22">Burris, David L.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Price%2C+Christopher%22">Price, Christopher</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> cprice@udel.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jul2025, Vol. 53 Issue 7, p1672-1688. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Articular+cartilage%22">Articular cartilage</searchLink><br /><searchLink fieldCode="DE" term="%22Dead+loads+%28Mechanics%29%22">Dead loads (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+fluid%22">Extracellular fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Exudation+%28Botany%29%22">Exudation (Botany)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Understanding how obesity—a key risk factor for osteoarthritis—effects articular cartilage function is critical to understand OA pathoetiology. Cartilage, a biphasic material, supports vanishingly low friction coefficients in vivo, but is tribomechanically compromised by load-induced interstitial pressure/lubrication loss. To maintain tribomechanical function, cartilage must recover fluid lost to habitual/average contact stresses, a problem obesity likely exacerbates. Recently, we have shown that articulation/sliding drives robust interstitial fluid recovery and indefinite maintenance of biofidelic tissue strains and frictions through generation of hydrodynamic pressures within cartilage contact interfaces, i.e., via 'tribological rehydration.' However, the impact of elevated contact stresses on tribological rehydration and cartilage's function/lubrication remains unknown. Methods: Using our convergent stationary contact area (cSCA) testing approach on ovine stifle cartilage explants bathed in PBS, we aimed to elucidate several points: (1) the effect of elevated contact stress on tribological rehydration during high-speed articulation, and how (2) cartilage material properties and (3) sliding speed influence contact stress-dependent fluid exudation, rehydration, and lubrication. Results: Overall, we identified that (i) contact stress, across a narrow range, and (ii) static loading time are key controllers of tribological rehydration magnitude, compression accumulation, and equilibrium/total compression under biofidelic cSCA loading and sliding conditions. However, over the range tested (i.e., 0.2–0.8 MPa), (iii) contact stresses had no appreciable effect on cartilage's remarkable lubricity in the cSCA. Conclusions: These results show that obesity is likely to directly physically impair articular cartilage function, and that obesity-driven tissue compression/strain, and not friction per se, may be the primary mechanical driver of cartilage dysfunction and OA risk. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-025-03708-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1672 Subjects: – SubjectFull: Articular cartilage Type: general – SubjectFull: Dead loads (Mechanics) Type: general – SubjectFull: Extracellular fluid Type: general – SubjectFull: Medical sciences Type: general – SubjectFull: Exudation (Botany) Type: general Titles: – TitleFull: Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Akanda, Shamimur R. – PersonEntity: Name: NameFull: Kupratis, Meghan E. – PersonEntity: Name: NameFull: Bhattacharjee, Arnab – PersonEntity: Name: NameFull: Benson, Jamie – PersonEntity: Name: NameFull: Burris, David L. – PersonEntity: Name: NameFull: Price, Christopher IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 53 – Type: issue Value: 7 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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