Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury.
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| Title: | Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury. |
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| Authors: | Patton, Declan A.1 (AUTHOR) pattonda@chop.edu, Grunig, Ciara S.2 (AUTHOR), McQuaid, Jessica R.2 (AUTHOR), Dodd, Andrew B.2 (AUTHOR), Pacheco, Mandy K.2 (AUTHOR), Ling, Josef M.2 (AUTHOR), Wick, Tracey V.2 (AUTHOR), Sasi Kumar, Divyasree2 (AUTHOR), Zotev, Vadim2 (AUTHOR), Kinsler, Rachel E.3 (AUTHOR), Arbogast, Kristy B.1,4 (AUTHOR), Mayer, Andrew R.2,5,6,7 (AUTHOR) |
| Source: | Annals of Biomedical Engineering. Jul2025, Vol. 53 Issue 7, p1663-1671. 9p. |
| Subjects: | Angular velocity, Angular acceleration, Brain injuries, Kinematics, Head injuries |
| Abstract: | Purpose: Large mammal head injury models allow the pathophysiological response associated with traumatic brain injury (TBI) to be studied in vivo with precise control of the physical parameters. However, only some studies have used skull-mounted sensors to measure the kinematics of the animal head rather than relying on measurements of the system delivering the impact. Therefore, the aim of the current study was to compare the kinematics between a rotational injury device (HYGE, Inc., Kittanning, PA) and the head in a swine model of TBI across a range of target peak angular velocities. Methods: Sexually mature Yucatan swine were subjected to a rotational TBI via the HYGE device at one of three targeted peak angular velocities: 110 rad/s (n = 16), 145 rad/s (n = 12) or 170 rad/s (n = 11). Sensor packages were used to measure both the angular kinematics of the animal head and HYGE device swing arm. Results: Peak angular velocity of the animal head was on average 18–33% lower compared to that of the HYGE device swing arm with greater relative differences for greater target peak angular velocities. Similarly, peak angular acceleration of the animal head was lower than that of the HYGE device sing arm by 11–34% on average with greater relative differences for greater target peak angular velocities. Conclusions: This study highlights the importance of directly measuring the head kinematics of the animal in TBI models for the purpose of directional comparisons, finite element simulations, and/or scaling kinematics from human-to-animal to determine boundary conditions or animal-to-human to develop injury criteria. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 186104902 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Patton%2C+Declan+A%2E%22">Patton, Declan A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> pattonda@chop.edu</i><br /><searchLink fieldCode="AR" term="%22Grunig%2C+Ciara+S%2E%22">Grunig, Ciara S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McQuaid%2C+Jessica+R%2E%22">McQuaid, Jessica R.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dodd%2C+Andrew+B%2E%22">Dodd, Andrew B.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pacheco%2C+Mandy+K%2E%22">Pacheco, Mandy K.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ling%2C+Josef+M%2E%22">Ling, Josef M.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wick%2C+Tracey+V%2E%22">Wick, Tracey V.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sasi+Kumar%2C+Divyasree%22">Sasi Kumar, Divyasree</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zotev%2C+Vadim%22">Zotev, Vadim</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kinsler%2C+Rachel+E%2E%22">Kinsler, Rachel E.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arbogast%2C+Kristy+B%2E%22">Arbogast, Kristy B.</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayer%2C+Andrew+R%2E%22">Mayer, Andrew R.</searchLink><relatesTo>2,5,6,7</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Jul2025, Vol. 53 Issue 7, p1663-1671. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Angular+velocity%22">Angular velocity</searchLink><br /><searchLink fieldCode="DE" term="%22Angular+acceleration%22">Angular acceleration</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+injuries%22">Brain injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Kinematics%22">Kinematics</searchLink><br /><searchLink fieldCode="DE" term="%22Head+injuries%22">Head injuries</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Large mammal head injury models allow the pathophysiological response associated with traumatic brain injury (TBI) to be studied in vivo with precise control of the physical parameters. However, only some studies have used skull-mounted sensors to measure the kinematics of the animal head rather than relying on measurements of the system delivering the impact. Therefore, the aim of the current study was to compare the kinematics between a rotational injury device (HYGE, Inc., Kittanning, PA) and the head in a swine model of TBI across a range of target peak angular velocities. Methods: Sexually mature Yucatan swine were subjected to a rotational TBI via the HYGE device at one of three targeted peak angular velocities: 110 rad/s (n = 16), 145 rad/s (n = 12) or 170 rad/s (n = 11). Sensor packages were used to measure both the angular kinematics of the animal head and HYGE device swing arm. Results: Peak angular velocity of the animal head was on average 18–33% lower compared to that of the HYGE device swing arm with greater relative differences for greater target peak angular velocities. Similarly, peak angular acceleration of the animal head was lower than that of the HYGE device sing arm by 11–34% on average with greater relative differences for greater target peak angular velocities. Conclusions: This study highlights the importance of directly measuring the head kinematics of the animal in TBI models for the purpose of directional comparisons, finite element simulations, and/or scaling kinematics from human-to-animal to determine boundary conditions or animal-to-human to develop injury criteria. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-025-03736-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1663 Subjects: – SubjectFull: Angular velocity Type: general – SubjectFull: Angular acceleration Type: general – SubjectFull: Brain injuries Type: general – SubjectFull: Kinematics Type: general – SubjectFull: Head injuries Type: general Titles: – TitleFull: Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Patton, Declan A. – PersonEntity: Name: NameFull: Grunig, Ciara S. – PersonEntity: Name: NameFull: McQuaid, Jessica R. – PersonEntity: Name: NameFull: Dodd, Andrew B. – PersonEntity: Name: NameFull: Pacheco, Mandy K. – PersonEntity: Name: NameFull: Ling, Josef M. – PersonEntity: Name: NameFull: Wick, Tracey V. – PersonEntity: Name: NameFull: Sasi Kumar, Divyasree – PersonEntity: Name: NameFull: Zotev, Vadim – PersonEntity: Name: NameFull: Kinsler, Rachel E. – PersonEntity: Name: NameFull: Arbogast, Kristy B. – PersonEntity: Name: NameFull: Mayer, Andrew R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 53 – Type: issue Value: 7 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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