Bilayer Nanofiber Membrane Based on Curcumin‐Loaded Polycaprolactone/Carboxymethyl Chitosan for Prevention of Epidural Adhesions.
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| Title: | Bilayer Nanofiber Membrane Based on Curcumin‐Loaded Polycaprolactone/Carboxymethyl Chitosan for Prevention of Epidural Adhesions. |
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| Authors: | Delkhosh, Niloofar1 (AUTHOR), Mirzadeh, Hamid1 (AUTHOR) mirzadeh@aut.ac.ir, Bagheri‐Khoulenjani, Shadab1,2 (AUTHOR) shadab.bagherikhoulenjani@unisa.edu.au |
| Source: | Polymers for Advanced Technologies. Jun2025, Vol. 36 Issue 6, p1-14. 14p. |
| Subjects: | Tissue adhesions, Spinal cord surgery, Surgical site, Polyethylene oxide, Scanning electron microscopy |
| Abstract: | Epidural adhesions are a common complication following spinal cord surgery, often resulting in severe spinal pain and, in many cases, necessitating additional surgical intervention. In this study, bilayer membranes were fabricated using the electrospinning method to prevent postsurgical epidural adhesions and accelerate the healing process. The membranes consisted of curcumin (CUR)‐loaded polycaprolactone (PCL) nanofibers as the exterior layer, which should be in contact with the adjacent tissues, and carboxymethyl chitosan/polyethylene oxide (CMC/PEO) nanofibers as the interior layer, which should be in contact with the surgical site. The PCL layer, designed for its anti‐adhesion properties, was loaded with 5 and 10 wt.% CUR, while the CMC/PEO layer was optimized to promote tissue regeneration and, as a result of that, to accelerate the healing process. Characterization of the membranes was performed using scanning electron microscopy (SEM), attenuated total reflection Fourier transformed infrared (ATR‐FTIR), X‐ray diffraction (XRD), contact angle measurements, hydrolytic degradation studies, in vitro cell studies, and muco‐adhesion analysis. CUR release, evaluated through UV/Vis spectrophotometry, showed that membranes with 10 wt.% CUR exhibited a higher release rate than those with 5 wt.%, enhancing the healing process due to CUR's anti‐inflammatory properties. Muco‐adhesion analysis revealed that the CMC/PEO layer demonstrated 2.5 times higher maximum detachment force (MDF) compared to the PCL/CUR layer, indicating the PCL layer's effectiveness in preventing adhesions. In vitro cell studies, including MTT assays, confirmed the biocompatibility of all membranes. Furthermore, cell attachment studies indicated greater adhesion to the CMC/PEO layer, underscoring the bilayer membrane's potential for both preventing epidural adhesions and promoting tissue regeneration. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 186162081 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bilayer Nanofiber Membrane Based on Curcumin‐Loaded Polycaprolactone/Carboxymethyl Chitosan for Prevention of Epidural Adhesions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Delkhosh%2C+Niloofar%22">Delkhosh, Niloofar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mirzadeh%2C+Hamid%22">Mirzadeh, Hamid</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mirzadeh@aut.ac.ir</i><br /><searchLink fieldCode="AR" term="%22Bagheri‐Khoulenjani%2C+Shadab%22">Bagheri‐Khoulenjani, Shadab</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> shadab.bagherikhoulenjani@unisa.edu.au</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+for+Advanced+Technologies%22">Polymers for Advanced Technologies</searchLink>. Jun2025, Vol. 36 Issue 6, p1-14. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tissue+adhesions%22">Tissue adhesions</searchLink><br /><searchLink fieldCode="DE" term="%22Spinal+cord+surgery%22">Spinal cord surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+site%22">Surgical site</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene+oxide%22">Polyethylene oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopy%22">Scanning electron microscopy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Epidural adhesions are a common complication following spinal cord surgery, often resulting in severe spinal pain and, in many cases, necessitating additional surgical intervention. In this study, bilayer membranes were fabricated using the electrospinning method to prevent postsurgical epidural adhesions and accelerate the healing process. The membranes consisted of curcumin (CUR)‐loaded polycaprolactone (PCL) nanofibers as the exterior layer, which should be in contact with the adjacent tissues, and carboxymethyl chitosan/polyethylene oxide (CMC/PEO) nanofibers as the interior layer, which should be in contact with the surgical site. The PCL layer, designed for its anti‐adhesion properties, was loaded with 5 and 10 wt.% CUR, while the CMC/PEO layer was optimized to promote tissue regeneration and, as a result of that, to accelerate the healing process. Characterization of the membranes was performed using scanning electron microscopy (SEM), attenuated total reflection Fourier transformed infrared (ATR‐FTIR), X‐ray diffraction (XRD), contact angle measurements, hydrolytic degradation studies, in vitro cell studies, and muco‐adhesion analysis. CUR release, evaluated through UV/Vis spectrophotometry, showed that membranes with 10 wt.% CUR exhibited a higher release rate than those with 5 wt.%, enhancing the healing process due to CUR's anti‐inflammatory properties. Muco‐adhesion analysis revealed that the CMC/PEO layer demonstrated 2.5 times higher maximum detachment force (MDF) compared to the PCL/CUR layer, indicating the PCL layer's effectiveness in preventing adhesions. In vitro cell studies, including MTT assays, confirmed the biocompatibility of all membranes. Furthermore, cell attachment studies indicated greater adhesion to the CMC/PEO layer, underscoring the bilayer membrane's potential for both preventing epidural adhesions and promoting tissue regeneration. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers for Advanced Technologies is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/pat.70217 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 1 Subjects: – SubjectFull: Tissue adhesions Type: general – SubjectFull: Spinal cord surgery Type: general – SubjectFull: Surgical site Type: general – SubjectFull: Polyethylene oxide Type: general – SubjectFull: Scanning electron microscopy Type: general Titles: – TitleFull: Bilayer Nanofiber Membrane Based on Curcumin‐Loaded Polycaprolactone/Carboxymethyl Chitosan for Prevention of Epidural Adhesions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Delkhosh, Niloofar – PersonEntity: Name: NameFull: Mirzadeh, Hamid – PersonEntity: Name: NameFull: Bagheri‐Khoulenjani, Shadab IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 10427147 Numbering: – Type: volume Value: 36 – Type: issue Value: 6 Titles: – TitleFull: Polymers for Advanced Technologies Type: main |
| ResultId | 1 |
