Efficacy of LASER for de-epithelialization of free gingival graft: a systematic review.
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| Title: | Efficacy of LASER for de-epithelialization of free gingival graft: a systematic review. |
|---|---|
| Authors: | Hazrati, Parham1 (AUTHOR) hazrati@umich.edu, Baniameri, Sahar1 (AUTHOR) saharban@umich.edu, Sabri, Hamoun1 (AUTHOR) hsabri@umich.edu, Chele, Dumitru1 (AUTHOR) dchele@umich.edu, Stuhr, Sandra1 (AUTHOR) sstuhr@umich.edu |
| Source: | Lasers in Medical Science. 6/27/2025, Vol. 40 Issue 1, p1-12. 12p. |
| Subjects: | Clinical trials, Semiconductor lasers, Laser therapy, Science databases, Connective tissues, Gingival grafts |
| Abstract: | This systematic review primarily aimed to investigate the efficacy of de-epithelializing free gingival graft (FGG) using LASER and, secondarily, to evaluate the clinical outcomes of soft tissue augmentation using LASER-de-epithelialized connective tissue grafts (CTGs). Following PRISMA guidelines, an electronic search was conducted in PubMed/MEDLINE, Scopus, Embase, and Web of Science databases without date or language restrictions on February 4, 2025. Clinical studies employing LASER for de-epithelializing FGG were considered eligible. The primary outcome was successful epithelium removal, while the main secondary outcomes were mean and complete root coverage percentage. Quality appraisal of the included studies was executed according to the revised Cochrane risk-of-bias tool for randomized trials (RoB2) and Risk of Bias in Non-randomized Studies - of Interventions (ROBINS-I). Of 243 studies, three met all eligibility criteria. Two randomized controlled clinical trials (RCTs), and one pre-post study were included. CO2, Er: YAG, and diode LASERs were utilized in the included studies. Power was set to 1 and 2 W in two and one studies, respectively. Epithelium removal was not quantitatively reported in any of the included studies, but complete removal of epithelium with LASER was reported qualitatively in one study. In all the included studies, LASERs yielded clinical outcomes comparable to blades, with minor superiorities in aesthetic outcomes observed with LASERs. LASERs show potential for successful removal of epithelium from FGG without causing safety issues or complications. However, the evidence on this topic remains limited, highlighting the need for well-conducted and reported RCTs. Registration The protocol of this systematic review was registered on PROSPERO with the ID CRD42025646636. Clinical Trial Number Not applicable. [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 186243177 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Efficacy of LASER for de-epithelialization of free gingival graft: a systematic review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hazrati%2C+Parham%22">Hazrati, Parham</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hazrati@umich.edu</i><br /><searchLink fieldCode="AR" term="%22Baniameri%2C+Sahar%22">Baniameri, Sahar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> saharban@umich.edu</i><br /><searchLink fieldCode="AR" term="%22Sabri%2C+Hamoun%22">Sabri, Hamoun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> hsabri@umich.edu</i><br /><searchLink fieldCode="AR" term="%22Chele%2C+Dumitru%22">Chele, Dumitru</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dchele@umich.edu</i><br /><searchLink fieldCode="AR" term="%22Stuhr%2C+Sandra%22">Stuhr, Sandra</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sstuhr@umich.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 6/27/2025, Vol. 40 Issue 1, p1-12. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Semiconductor+lasers%22">Semiconductor lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+therapy%22">Laser therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Science+databases%22">Science databases</searchLink><br /><searchLink fieldCode="DE" term="%22Connective+tissues%22">Connective tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Gingival+grafts%22">Gingival grafts</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This systematic review primarily aimed to investigate the efficacy of de-epithelializing free gingival graft (FGG) using LASER and, secondarily, to evaluate the clinical outcomes of soft tissue augmentation using LASER-de-epithelialized connective tissue grafts (CTGs). Following PRISMA guidelines, an electronic search was conducted in PubMed/MEDLINE, Scopus, Embase, and Web of Science databases without date or language restrictions on February 4, 2025. Clinical studies employing LASER for de-epithelializing FGG were considered eligible. The primary outcome was successful epithelium removal, while the main secondary outcomes were mean and complete root coverage percentage. Quality appraisal of the included studies was executed according to the revised Cochrane risk-of-bias tool for randomized trials (RoB2) and Risk of Bias in Non-randomized Studies - of Interventions (ROBINS-I). Of 243 studies, three met all eligibility criteria. Two randomized controlled clinical trials (RCTs), and one pre-post study were included. CO2, Er: YAG, and diode LASERs were utilized in the included studies. Power was set to 1 and 2 W in two and one studies, respectively. Epithelium removal was not quantitatively reported in any of the included studies, but complete removal of epithelium with LASER was reported qualitatively in one study. In all the included studies, LASERs yielded clinical outcomes comparable to blades, with minor superiorities in aesthetic outcomes observed with LASERs. LASERs show potential for successful removal of epithelium from FGG without causing safety issues or complications. However, the evidence on this topic remains limited, highlighting the need for well-conducted and reported RCTs. Registration The protocol of this systematic review was registered on PROSPERO with the ID CRD42025646636. Clinical Trial Number Not applicable. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-025-04554-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1 Subjects: – SubjectFull: Clinical trials Type: general – SubjectFull: Semiconductor lasers Type: general – SubjectFull: Laser therapy Type: general – SubjectFull: Science databases Type: general – SubjectFull: Connective tissues Type: general – SubjectFull: Gingival grafts Type: general Titles: – TitleFull: Efficacy of LASER for de-epithelialization of free gingival graft: a systematic review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hazrati, Parham – PersonEntity: Name: NameFull: Baniameri, Sahar – PersonEntity: Name: NameFull: Sabri, Hamoun – PersonEntity: Name: NameFull: Chele, Dumitru – PersonEntity: Name: NameFull: Stuhr, Sandra IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 06 Text: 6/27/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 40 – Type: issue Value: 1 Titles: – TitleFull: Lasers in Medical Science Type: main |
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