TiO 2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties.
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| Title: | TiO 2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties. |
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| Authors: | Fletes-Vargas, Gabriela1 (AUTHOR) natalha.vicentina@ufvjm.edu.br, Rodríguez-Rodríguez, Rogelio1,2 (AUTHOR) kelly.kato@ufvjm.edu.br, Pinto, Natalha Vicentina2,3 (AUTHOR), Kato, Kelly Cristina1,2 (AUTHOR), Carneiro, Guilherme2 (AUTHOR), Rodrigues, Ana Paula2,3 (AUTHOR), Rodrigues-Martins, Helen2 (AUTHOR), Espinosa-Andrews, Hugo3 (AUTHOR) |
| Source: | Nanomaterials (2079-4991). Jun2025, Vol. 15 Issue 12, p926. 12p. |
| Subjects: | Inhibitory Concentration 50, Titanium dioxide nanoparticles, Japanese knotweed, Wound healing, Cytotoxins, Resveratrol |
| Abstract: | The dry roots of Polygonum cuspidatum contain resveratrol, a compound known for its antimicrobial and protective effects against oxidative stress, which is associated with impaired wound healing. In this study, titanium dioxide nanoparticles (TiO2NPs) were loaded with a P. cuspidatum extract (TiO2-loaded extract NPs), and the resveratrol release profile, hemocompatibility, antioxidant, cytotoxic, and antimicrobial activities were evaluated. The results demonstrated that TiO2-loaded extract NPs exhibited antioxidant activity for DPPH (Inhibitory Concentration 50 (IC50) = 62.31 mg Trolox Equivalent (TE)/mL) and ABTS+ (IC50 = 4.8 mg TE/mL) assays, along with suitable hemocompatibility (3.02% at 10 mg/mL), in comparison with bulk TiO2 NPs. Additionally, temperature influenced the resveratrol release over time. The P. cuspidatum extract alone showed strong antibacterial activity, with a Minimal Inhibitory Concentration (MIC) of 5 µg/mL, TiO2-loaded extract NPs showed MIC values about 50 mg/mL, while bulk TiO2 NPs exhibited no antibacterial effect against the tested strains. In contrast, the P. cuspidatum extract, the TiO2-loaded extract NPs, and the bulk TiO2 NPs did not demonstrate antifungal activity against Candida albicans and C. glabrata. Moreover, TiO2-loaded extract NPs showed no cytotoxicity against the L-929 cell line at concentrations ranging from 1.5 to 150 µg/mL, unlike TiO2 NPs, which exhibited high cytotoxic concentrations between 9.4 and 300 µg/mL. These findings suggest that TiO2-loaded extract NPs effectively control the release of resveratrol and hold promises for applications in skin management and wound healing. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 186258324 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: TiO 2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fletes-Vargas%2C+Gabriela%22">Fletes-Vargas, Gabriela</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> natalha.vicentina@ufvjm.edu.br</i><br /><searchLink fieldCode="AR" term="%22Rodríguez-Rodríguez%2C+Rogelio%22">Rodríguez-Rodríguez, Rogelio</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> kelly.kato@ufvjm.edu.br</i><br /><searchLink fieldCode="AR" term="%22Pinto%2C+Natalha+Vicentina%22">Pinto, Natalha Vicentina</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kato%2C+Kelly+Cristina%22">Kato, Kelly Cristina</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carneiro%2C+Guilherme%22">Carneiro, Guilherme</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigues%2C+Ana+Paula%22">Rodrigues, Ana Paula</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigues-Martins%2C+Helen%22">Rodrigues-Martins, Helen</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Espinosa-Andrews%2C+Hugo%22">Espinosa-Andrews, Hugo</searchLink><relatesTo>3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Jun2025, Vol. 15 Issue 12, p926. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Inhibitory+Concentration+50%22">Inhibitory Concentration 50</searchLink><br /><searchLink fieldCode="DE" term="%22Titanium+dioxide+nanoparticles%22">Titanium dioxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Japanese+knotweed%22">Japanese knotweed</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Cytotoxins%22">Cytotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Resveratrol%22">Resveratrol</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The dry roots of Polygonum cuspidatum contain resveratrol, a compound known for its antimicrobial and protective effects against oxidative stress, which is associated with impaired wound healing. In this study, titanium dioxide nanoparticles (TiO2NPs) were loaded with a P. cuspidatum extract (TiO2-loaded extract NPs), and the resveratrol release profile, hemocompatibility, antioxidant, cytotoxic, and antimicrobial activities were evaluated. The results demonstrated that TiO2-loaded extract NPs exhibited antioxidant activity for DPPH (Inhibitory Concentration 50 (IC50) = 62.31 mg Trolox Equivalent (TE)/mL) and ABTS+ (IC50 = 4.8 mg TE/mL) assays, along with suitable hemocompatibility (3.02% at 10 mg/mL), in comparison with bulk TiO2 NPs. Additionally, temperature influenced the resveratrol release over time. The P. cuspidatum extract alone showed strong antibacterial activity, with a Minimal Inhibitory Concentration (MIC) of 5 µg/mL, TiO2-loaded extract NPs showed MIC values about 50 mg/mL, while bulk TiO2 NPs exhibited no antibacterial effect against the tested strains. In contrast, the P. cuspidatum extract, the TiO2-loaded extract NPs, and the bulk TiO2 NPs did not demonstrate antifungal activity against Candida albicans and C. glabrata. Moreover, TiO2-loaded extract NPs showed no cytotoxicity against the L-929 cell line at concentrations ranging from 1.5 to 150 µg/mL, unlike TiO2 NPs, which exhibited high cytotoxic concentrations between 9.4 and 300 µg/mL. These findings suggest that TiO2-loaded extract NPs effectively control the release of resveratrol and hold promises for applications in skin management and wound healing. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano15120926 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 926 Subjects: – SubjectFull: Inhibitory Concentration 50 Type: general – SubjectFull: Titanium dioxide nanoparticles Type: general – SubjectFull: Japanese knotweed Type: general – SubjectFull: Wound healing Type: general – SubjectFull: Cytotoxins Type: general – SubjectFull: Resveratrol Type: general Titles: – TitleFull: TiO 2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fletes-Vargas, Gabriela – PersonEntity: Name: NameFull: Rodríguez-Rodríguez, Rogelio – PersonEntity: Name: NameFull: Pinto, Natalha Vicentina – PersonEntity: Name: NameFull: Kato, Kelly Cristina – PersonEntity: Name: NameFull: Carneiro, Guilherme – PersonEntity: Name: NameFull: Rodrigues, Ana Paula – PersonEntity: Name: NameFull: Rodrigues-Martins, Helen – PersonEntity: Name: NameFull: Espinosa-Andrews, Hugo IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: Jun2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 15 – Type: issue Value: 12 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
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