TiO 2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties.
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| Title: | TiO 2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties. |
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| Authors: | Fletes-Vargas, Gabriela1 (AUTHOR) natalha.vicentina@ufvjm.edu.br, Rodríguez-Rodríguez, Rogelio1,2 (AUTHOR) kelly.kato@ufvjm.edu.br, Pinto, Natalha Vicentina2,3 (AUTHOR), Kato, Kelly Cristina1,2 (AUTHOR), Carneiro, Guilherme2 (AUTHOR), Rodrigues, Ana Paula2,3 (AUTHOR), Rodrigues-Martins, Helen2 (AUTHOR), Espinosa-Andrews, Hugo3 (AUTHOR) |
| Source: | Nanomaterials (2079-4991). Jun2025, Vol. 15 Issue 12, p926. 12p. |
| Subjects: | Inhibitory Concentration 50, Titanium dioxide nanoparticles, Japanese knotweed, Wound healing, Cytotoxins, Resveratrol |
| Abstract: | The dry roots of Polygonum cuspidatum contain resveratrol, a compound known for its antimicrobial and protective effects against oxidative stress, which is associated with impaired wound healing. In this study, titanium dioxide nanoparticles (TiO2NPs) were loaded with a P. cuspidatum extract (TiO2-loaded extract NPs), and the resveratrol release profile, hemocompatibility, antioxidant, cytotoxic, and antimicrobial activities were evaluated. The results demonstrated that TiO2-loaded extract NPs exhibited antioxidant activity for DPPH (Inhibitory Concentration 50 (IC50) = 62.31 mg Trolox Equivalent (TE)/mL) and ABTS+ (IC50 = 4.8 mg TE/mL) assays, along with suitable hemocompatibility (3.02% at 10 mg/mL), in comparison with bulk TiO2 NPs. Additionally, temperature influenced the resveratrol release over time. The P. cuspidatum extract alone showed strong antibacterial activity, with a Minimal Inhibitory Concentration (MIC) of 5 µg/mL, TiO2-loaded extract NPs showed MIC values about 50 mg/mL, while bulk TiO2 NPs exhibited no antibacterial effect against the tested strains. In contrast, the P. cuspidatum extract, the TiO2-loaded extract NPs, and the bulk TiO2 NPs did not demonstrate antifungal activity against Candida albicans and C. glabrata. Moreover, TiO2-loaded extract NPs showed no cytotoxicity against the L-929 cell line at concentrations ranging from 1.5 to 150 µg/mL, unlike TiO2 NPs, which exhibited high cytotoxic concentrations between 9.4 and 300 µg/mL. These findings suggest that TiO2-loaded extract NPs effectively control the release of resveratrol and hold promises for applications in skin management and wound healing. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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