Photobiomodulation control the expression of MMP, TNF-α and NK-1 receptors, improving allodynia and cartilage resistance in rheumatoid arthritis model.
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| Title: | Photobiomodulation control the expression of MMP, TNF-α and NK-1 receptors, improving allodynia and cartilage resistance in rheumatoid arthritis model. |
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| Authors: | Fernandes, Guilherme Henrique Cardoso1,2 (AUTHOR) gui_vete@hotmail.com, Labat Marcos, Rodrigo1 (AUTHOR) labatrm@gmail.com, Almeida dos Santos, Solange1 (AUTHOR) solangeasantos36@gmail.com, Jesus, Carlos Cesar Lopes1 (AUTHOR) caceloje@uni9.pro.br, Neto, Orlando Romano1 (AUTHOR) orlandoromano@uol.com.br, Oliveira, Ana Paula Ligeiro1 (AUTHOR) apligeiro@uni9.pro.br, Zamuner, Stella Regina1 (AUTHOR) stella.rz@uni9.pro.br, Cecatto, Rebeca Boltes1 (AUTHOR) rebeca.boltes@uni9.pro.br, Liebano, Richard Eloin3 (AUTHOR) liebano@gmail.com, Pinzano, Astrid4 (AUTHOR) astrid.pinzano@univ-lorraine.fr, Camilo de Carvalho, Paulo de Tarso1 (AUTHOR) rodrigolabat@yahoo.com.br, Ferrari Corrêa, João1,2 (AUTHOR) labat@uni9.pro.br |
| Source: | Lasers in Medical Science. 7/1/2025, Vol. 40 Issue 1, p1-13. 13p. |
| Subjects: | Tumor necrosis factors, Laboratory rats, Medical sciences, Photobiomodulation therapy, Matrix metalloproteinases |
| Abstract: | Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune disease that leads to irreversible cartilage destruction and affects multiple tissues. In vivo experimental studies have demonstrated that photobiomodulation therapy (PBM) produces beneficial effects on inflammation and pain modulation. This study aimed to evaluate the effects of topical PBM on the expression of matrix metalloproteinases (MMP-2, MMP-9, MMP-13), tumor necrosis factor-alpha (TNF-α), neurokinin-1 (NK1) receptors, mechanical allodynia, and cartilage mechanical resistance in a rat model of RA. RA was induced using type II collagen and Freund's adjuvant, followed by PBM treatment (808 nm, 2 J, 50 mW, three times per week). Euthanasia was performed at 7 and 14 days using an overdose of anesthetics, and knee cartilage samples were collected for subsequent analyses. PBM significantly reduced the expression of TNF-α and MMPs, preserved cartilage mechanical resistance, and decreased NK1 receptor expression, resulting in improved mechanical allodynia. Topical PBM (808 nm, 2 J, 50 mW) effectively minimized cartilage degradation and attenuated pain sensitivity in rats with induced RA. [ABSTRACT FROM AUTHOR] |
| Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 186308621 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Photobiomodulation control the expression of MMP, TNF-α and NK-1 receptors, improving allodynia and cartilage resistance in rheumatoid arthritis model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fernandes%2C+Guilherme+Henrique+Cardoso%22">Fernandes, Guilherme Henrique Cardoso</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> gui_vete@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Labat+Marcos%2C+Rodrigo%22">Labat Marcos, Rodrigo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> labatrm@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Almeida+dos+Santos%2C+Solange%22">Almeida dos Santos, Solange</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> solangeasantos36@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Jesus%2C+Carlos+Cesar+Lopes%22">Jesus, Carlos Cesar Lopes</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> caceloje@uni9.pro.br</i><br /><searchLink fieldCode="AR" term="%22Neto%2C+Orlando+Romano%22">Neto, Orlando Romano</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> orlandoromano@uol.com.br</i><br /><searchLink fieldCode="AR" term="%22Oliveira%2C+Ana+Paula+Ligeiro%22">Oliveira, Ana Paula Ligeiro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> apligeiro@uni9.pro.br</i><br /><searchLink fieldCode="AR" term="%22Zamuner%2C+Stella+Regina%22">Zamuner, Stella Regina</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> stella.rz@uni9.pro.br</i><br /><searchLink fieldCode="AR" term="%22Cecatto%2C+Rebeca+Boltes%22">Cecatto, Rebeca Boltes</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rebeca.boltes@uni9.pro.br</i><br /><searchLink fieldCode="AR" term="%22Liebano%2C+Richard+Eloin%22">Liebano, Richard Eloin</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> liebano@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Pinzano%2C+Astrid%22">Pinzano, Astrid</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> astrid.pinzano@univ-lorraine.fr</i><br /><searchLink fieldCode="AR" term="%22Camilo+de+Carvalho%2C+Paulo+de+Tarso%22">Camilo de Carvalho, Paulo de Tarso</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rodrigolabat@yahoo.com.br</i><br /><searchLink fieldCode="AR" term="%22Ferrari+Corrêa%2C+João%22">Ferrari Corrêa, João</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> labat@uni9.pro.br</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 7/1/2025, Vol. 40 Issue 1, p1-13. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Photobiomodulation+therapy%22">Photobiomodulation therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Matrix+metalloproteinases%22">Matrix metalloproteinases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune disease that leads to irreversible cartilage destruction and affects multiple tissues. In vivo experimental studies have demonstrated that photobiomodulation therapy (PBM) produces beneficial effects on inflammation and pain modulation. This study aimed to evaluate the effects of topical PBM on the expression of matrix metalloproteinases (MMP-2, MMP-9, MMP-13), tumor necrosis factor-alpha (TNF-α), neurokinin-1 (NK1) receptors, mechanical allodynia, and cartilage mechanical resistance in a rat model of RA. RA was induced using type II collagen and Freund's adjuvant, followed by PBM treatment (808 nm, 2 J, 50 mW, three times per week). Euthanasia was performed at 7 and 14 days using an overdose of anesthetics, and knee cartilage samples were collected for subsequent analyses. PBM significantly reduced the expression of TNF-α and MMPs, preserved cartilage mechanical resistance, and decreased NK1 receptor expression, resulting in improved mechanical allodynia. Topical PBM (808 nm, 2 J, 50 mW) effectively minimized cartilage degradation and attenuated pain sensitivity in rats with induced RA. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10103-025-04557-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Tumor necrosis factors Type: general – SubjectFull: Laboratory rats Type: general – SubjectFull: Medical sciences Type: general – SubjectFull: Photobiomodulation therapy Type: general – SubjectFull: Matrix metalloproteinases Type: general Titles: – TitleFull: Photobiomodulation control the expression of MMP, TNF-α and NK-1 receptors, improving allodynia and cartilage resistance in rheumatoid arthritis model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fernandes, Guilherme Henrique Cardoso – PersonEntity: Name: NameFull: Labat Marcos, Rodrigo – PersonEntity: Name: NameFull: Almeida dos Santos, Solange – PersonEntity: Name: NameFull: Jesus, Carlos Cesar Lopes – PersonEntity: Name: NameFull: Neto, Orlando Romano – PersonEntity: Name: NameFull: Oliveira, Ana Paula Ligeiro – PersonEntity: Name: NameFull: Zamuner, Stella Regina – PersonEntity: Name: NameFull: Cecatto, Rebeca Boltes – PersonEntity: Name: NameFull: Liebano, Richard Eloin – PersonEntity: Name: NameFull: Pinzano, Astrid – PersonEntity: Name: NameFull: Camilo de Carvalho, Paulo de Tarso – PersonEntity: Name: NameFull: Ferrari Corrêa, João IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 7/1/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 02688921 Numbering: – Type: volume Value: 40 – Type: issue Value: 1 Titles: – TitleFull: Lasers in Medical Science Type: main |
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