Comparison of twelve‐layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI.
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| Title: | Comparison of twelve‐layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI. |
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| Authors: | Gallinnis, Patrik Jan1 (AUTHOR), Möller, Rika1 (AUTHOR), Ljimani, Alexandra1 (AUTHOR) alexandra.ljimani@med.uni-duesseldorf.de, Cabuk, Yusuf1 (AUTHOR), Scheuer, Marie1 (AUTHOR), Böttger, Charlotte1 (AUTHOR), Liang, Cecilia2 (AUTHOR), Nagel, Armin M.3,4 (AUTHOR), Bechler, Eric1,5 (AUTHOR), Wittsack, Hans‐Jörg1 (AUTHOR), Müller‐Lutz, Anja1 (AUTHOR), Kamp, Benedikt1 (AUTHOR) |
| Source: | Magnetic Resonance in Medicine. Sep2025, Vol. 94 Issue 3, p1318-1325. 8p. |
| Subjects: | Magnetic resonance imaging, Functional magnetic resonance imaging, Standard deviations, Sodium, Radiologists |
| Abstract: | Purpose: 23Na MRI is a functional imaging technique that facilitates measurements of the renal corticomedullary sodium gradient (CMSG). The CMSG can be determined by a region of interest (ROI) in the renal parenchyma along the corticomedullary axis (Line method) or by dividing the renal parenchyma into concentric layers, using the twelve‐layer concentric objects (TLCO) method. The aim of this study was to investigate the differences, strengths, and weaknesses in determining the CMSG using these methods. Methods: Ten healthy volunteers were examined on a 3 T MRI‐system. 23Na images were acquired using a double‐tuned 23Na/1H surface coil and a golden angle (GA) density‐adapted 3D radial (DA‐3D‐RAD) sequence. The CMSG was determined with the Line and TLCO methods. Intra‐ and inter‐reader analyses were performed by two radiologists. Results: The evaluated CMSG by the two methods does not differ statistically significantly. Compared to the Line method, the TLCO method provides improved results in terms of reliability, precision, reproducibility, and concordance in intra‐ and inter‐reader analyses. A CMSG of (6.7 ± 2.6) mM/mm was determined using the TLCO method in the segmentation process with the lowest standard deviation. Conclusion: The TLCO method shows superior performance in determining the CMSG compared to the Line method. Accordingly, the use of the TLCO method is recommended for future renal CMSG studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 186342830 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparison of twelve‐layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gallinnis%2C+Patrik+Jan%22">Gallinnis, Patrik Jan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Möller%2C+Rika%22">Möller, Rika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ljimani%2C+Alexandra%22">Ljimani, Alexandra</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> alexandra.ljimani@med.uni-duesseldorf.de</i><br /><searchLink fieldCode="AR" term="%22Cabuk%2C+Yusuf%22">Cabuk, Yusuf</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scheuer%2C+Marie%22">Scheuer, Marie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Böttger%2C+Charlotte%22">Böttger, Charlotte</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liang%2C+Cecilia%22">Liang, Cecilia</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nagel%2C+Armin+M%2E%22">Nagel, Armin M.</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bechler%2C+Eric%22">Bechler, Eric</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wittsack%2C+Hans‐Jörg%22">Wittsack, Hans‐Jörg</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Müller‐Lutz%2C+Anja%22">Müller‐Lutz, Anja</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kamp%2C+Benedikt%22">Kamp, Benedikt</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Sep2025, Vol. 94 Issue 3, p1318-1325. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Standard+deviations%22">Standard deviations</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium%22">Sodium</searchLink><br /><searchLink fieldCode="DE" term="%22Radiologists%22">Radiologists</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: 23Na MRI is a functional imaging technique that facilitates measurements of the renal corticomedullary sodium gradient (CMSG). The CMSG can be determined by a region of interest (ROI) in the renal parenchyma along the corticomedullary axis (Line method) or by dividing the renal parenchyma into concentric layers, using the twelve‐layer concentric objects (TLCO) method. The aim of this study was to investigate the differences, strengths, and weaknesses in determining the CMSG using these methods. Methods: Ten healthy volunteers were examined on a 3 T MRI‐system. 23Na images were acquired using a double‐tuned 23Na/1H surface coil and a golden angle (GA) density‐adapted 3D radial (DA‐3D‐RAD) sequence. The CMSG was determined with the Line and TLCO methods. Intra‐ and inter‐reader analyses were performed by two radiologists. Results: The evaluated CMSG by the two methods does not differ statistically significantly. Compared to the Line method, the TLCO method provides improved results in terms of reliability, precision, reproducibility, and concordance in intra‐ and inter‐reader analyses. A CMSG of (6.7 ± 2.6) mM/mm was determined using the TLCO method in the segmentation process with the lowest standard deviation. Conclusion: The TLCO method shows superior performance in determining the CMSG compared to the Line method. Accordingly, the use of the TLCO method is recommended for future renal CMSG studies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.30525 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1318 Subjects: – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Standard deviations Type: general – SubjectFull: Sodium Type: general – SubjectFull: Radiologists Type: general Titles: – TitleFull: Comparison of twelve‐layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gallinnis, Patrik Jan – PersonEntity: Name: NameFull: Möller, Rika – PersonEntity: Name: NameFull: Ljimani, Alexandra – PersonEntity: Name: NameFull: Cabuk, Yusuf – PersonEntity: Name: NameFull: Scheuer, Marie – PersonEntity: Name: NameFull: Böttger, Charlotte – PersonEntity: Name: NameFull: Liang, Cecilia – PersonEntity: Name: NameFull: Nagel, Armin M. – PersonEntity: Name: NameFull: Bechler, Eric – PersonEntity: Name: NameFull: Wittsack, Hans‐Jörg – PersonEntity: Name: NameFull: Müller‐Lutz, Anja – PersonEntity: Name: NameFull: Kamp, Benedikt IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 94 – Type: issue Value: 3 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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